Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India

Emerging infectious diseases, Год журнала: 2021, Номер 27(9), С. 2349 - 2359

Опубликована: Авг. 19, 2021

During September-December 2020, we conducted a multicenter retrospective study across India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 patients, 187 (65.2%) had CAM; CAM prevalence was 0.27% hospitalized COVID-19 patients. We noted 2.1-fold rise in during the period compared with 2019. Uncontrolled diabetes mellitus most common underlying non-CAM only 32.6% COVID-19-related hypoxemia improper glucocorticoid use independently were associated CAM. The case-fatality rate at 12 weeks 45.7% but similar for Age, rhino-orbital-cerebral involvement, intensive care unit admission increased mortality rates; sequential antifungal drug treatment improved survival. pandemic has led increases India, partly from inappropriate use.

Язык: Английский

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Incidence, diagnosis and outcomes of COVID-19-associated pulmonary aspergillosis (CAPA): a systematic review

Journal of Hospital Infection, Год журнала: 2021, Номер 113, С. 115 - 129

Опубликована: Апрель 21, 2021

COVID-19-associated pulmonary aspergillosis (CAPA) is defined as invasive occurring in COVID-19 patients. The purpose of this review was to discuss the incidence, characteristics, diagnostic criteria, biomarkers, and outcomes hospitalized patients diagnosed with CAPA. A literature search performed through Pubmed Web Science databases for articles published up 20th March 2021. In 1421 patients, overall CAPA incidence 13.5% (range 2.5-35.0%). majority required mechanical ventilation (IMV). time diagnosis from illness onset varied between 8.0 16.0 days. However, intensive care unit (ICU) admission IMV initiation ranged 4.0-15.0 days 3.0-8.0 most common criteria were modified AspICU-Dutch/Belgian Mycosis Study Group IAPA-Verweij et al. total 77.6% had positive lower respiratory tract cultures, other fungal biomarkers bronchoalveolar lavage serum galactomannan 45.3% 18.2% mortality rate high at 48.4%, despite widespread use antifungals. Lengthy hospital ICU stays ranging 16.0-37.5 10.5-37.0 observed. prolonged duration 13.0-20.0 true likely remains unknown limited by lack standardized that rely solely on microbiological data direct or indirect detection Aspergillus specimens, particularly clinical conditions a low pretest probability. well-designed, multi-centre study determine optimal approach required.

Язык: Английский

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Global antimicrobial resistance and antibiotic use in COVID-19 patients within health facilities: A systematic review and meta-analysis of aggregated participant data

Journal of Infection, Год журнала: 2024, Номер 89(1), С. 106183 - 106183

Опубликована: Май 14, 2024

Язык: Английский

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Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection

European Respiratory Review, Год журнала: 2021, Номер 30(162), С. 210194 - 210194

Опубликована: Дек. 15, 2021

Acute manifestations of SARS-CoV-2 infection continue to impact the lives many across world. Post-acute sequelae coronavirus disease 2019 (COVID-19) may affect 10-30% survivors COVID-19, and post-acute COVID-19 (PASC)-pulmonary fibrosis is a long-term outcome associated with major morbidity. Data from prior outbreaks (severe acute respiratory syndrome Middle East syndrome) suggest that pulmonary will contribute morbidity, suggesting PASC-pulmonary should be thoroughly screened for through function testing cross-sectional imaging. As data accumulates on unique pathobiologic mechanisms underlying critical focus corollaries subacute chronic profibrotic phenotype must sought as well. Key aspects pathobiology account increased rates include monocyte/macrophage-T-cell circuits, RNA transcriptomics, protracted elevated levels inflammatory cytokines, duration illness ventilation. Mechanistic understanding central in determining therapeutic options ultimately play role transplant considerations. Well-designed cohort studies prospective clinical registries are needed. Clinicians, researchers healthcare systems actively address this complication PASC minimise disability, maximise quality life confront post-COVID-19 global health crisis.

Язык: Английский

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Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression

Clinical Microbiology and Infection, Год журнала: 2021, Номер 28(4), С. 491 - 501

Опубликована: Ноя. 26, 2021

Язык: Английский

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Comparing the clinical characteristics and outcomes of COVID-19-associate pulmonary aspergillosis (CAPA): a systematic review and meta-analysis

Infection, Год журнала: 2021, Номер 50(1), С. 43 - 56

Опубликована: Сен. 27, 2021

Язык: Английский

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Pathogenesis of Respiratory Viral and Fungal Coinfections

Clinical Microbiology Reviews, Год журнала: 2021, Номер 35(1)

Опубликована: Ноя. 17, 2021

Individuals suffering from severe viral respiratory tract infections have recently emerged as "at risk" groups for developing invasive fungal infections. Influenza virus is one of the most common causes acute lower worldwide. Fungal complicating influenza pneumonia are associated with increased disease severity and mortality, pulmonary aspergillosis being manifestation. Strikingly, similar observations been made during current coronavirus 2019 (COVID-19) pandemic. The copathogenesis coinfections complex involves a dynamic interplay between host immune defenses virulence microbes involved that often results in failure to return homeostasis. In this review, we discuss main mechanisms underlying susceptibility following A comprehensive understanding these interactions will aid development therapeutic modalities against newly identified targets prevent treat emerging coinfections.

Язык: Английский

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Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Сен. 5, 2023

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and major concern. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to severity in patients with COVID-19. Here, we report that microbiota post-COVID subjects had a remarkable predominance Enterobacteriaceae strains an antibiotic-resistant phenotype compared healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced feces. Fecal transplantation from germ-free mice led lung inflammation worse outcomes during pulmonary by multidrug-resistant Klebsiella pneumoniae. transplanted also exhibited poor cognitive performance. Overall, show prolonged impacts SARS-CoV-2 on persist after have cleared virus. Together, these data demonstrate can directly contribute sequelae, suggesting it may be potential therapeutic target.

Язык: Английский

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Risk factors and effect on mortality of superinfections in a newly established COVID-19 respiratory sub-intensive care unit at University Hospital in Rome

BMC Pulmonary Medicine, Год журнала: 2023, Номер 23(1)

Опубликована: Янв. 20, 2023

Little is known on the burden of co-infections and superinfections in a specific setting such as respiratory COVID-19 sub-intensive care unit. This study aims to (i) assess prevalence concurrent unit, (ii) evaluate risk factors for development (iii) impact in-hospital mortality.

Язык: Английский

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PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

Antimicrobial Agents and Chemotherapy, Год журнала: 2023, Номер 67(5)

Опубликована: Апрель 26, 2023

Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn wound infections, pneumonia, urinary tract more severe invasive diseases, which often multidrug resistant (MDR) or extensively drug resistant. Due to this, it is critical discover alternative antimicrobials, such as bacteriophage lysins, against these pathogens. Unfortunately, most lysins that target Gram-negative bacteria require additional modifications outer membrane permeabilizing agents be bactericidal. We identified four putative through bioinformatic analysis phage genomes in the NCBI database then expressed tested their intrinsic lytic activity vitro. The active lysin, PlyKp104, exhibited >5-log killing K. pneumoniae, P. aeruginosa, other representatives multidrug-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Acinetobacter baumannii, Enterobacter species) without further modification. PlyKp104 displayed rapid high over a wide pH range concentrations salt urea. Additionally, pulmonary surfactants low human serum did not inhibit also significantly reduced drug-resistant >2 logs murine skin infection model after one treatment wound, suggesting this lysin could used topical antimicrobial MDR infections.

Язык: Английский

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