Blood Reviews,
Год журнала:
2023,
Номер
60, С. 101075 - 101075
Опубликована: Март 20, 2023
ME/CFS
is
a
debilitating
chronic
condition
that
often
develops
after
viral
or
bacterial
infection.
Insight
from
the
study
of
Long
COVID/Post
Acute
Sequelae
COVID-19
(PASC),
post-viral
syndrome
associated
with
SARS-CoV-2
infection,
might
prove
to
be
useful
for
understanding
pathophysiological
mechanisms
ME/CFS.
Disease
presentation
similar
between
two
conditions,
and
subset
COVID
patients
meet
diagnostic
criteria
Since
characterized
by
significant
vascular
pathology
–
including
endothelial
dysfunction,
coagulopathy,
dysregulation
question
whether
not
same
biological
abnormalities
are
significance
in
arises.
Cardiac
have
while
now
been
documented
cohorts,
recent
studies
demonstrating
major
deficits
cerebral
blood
flow,
hence
dysregulation.
A
growing
body
research
accompanied
platelet
hyperactivation,
anomalous
clotting,
procoagulant
phenotype,
dysfunction.
Endothelial
damage
dysregulated
clotting
can
impair
substance
exchange
tissues,
result
hypoperfusion,
which
may
contribute
manifestation
certain
symptoms.
Here
we
review
literature
summarize
cardiovascular
haematological
findings
condition,
and,
this
context,
briefly
discuss
potential
role
previously-implicated
pathogens.
Overall,
cardiac
present
within
cohorts.
While
atherosclerotic
heart
disease
significantly
ME/CFS,
suboptimal
function
defined
reduced
output,
impaired
are,
these
do
appear
influenced
deconditioning.
Rather,
dysfunction
(autonomic)
nervous
system.
Plenty
recently
published
hyperactivity
as
well
processes.
It
particular
importance
determine
what
extent
symptom
severity,
if
systems
targeted
therapeutic
purposes.
Viral
reservoirs
herpesviruses
exist
most
likely
directly
indirectly.
This
highlights
studying
functioning,
vasculature,
coagulation
system
Microorganisms,
Год журнала:
2023,
Номер
11(12), С. 2959 - 2959
Опубликована: Дек. 11, 2023
The
presence
of
symptoms
after
an
acute
SARS-CoV-2
infection
(long-COVID)
has
become
a
worldwide
healthcare
emergency
but
remains
underestimated
and
undertreated
due
to
lack
recognition
the
condition
knowledge
underlying
mechanisms.
In
fact,
prevalence
post-COVID
ranges
from
50%
during
first
months
up
20%
two-years
after.
This
perspective
review
aimed
map
existing
literature
on
identify
gaps
in
guide
global
effort
toward
improved
understanding
long-COVID
suggest
future
research
directions.
There
is
plethora
symptomatology
that
can
be
COVID-19;
however,
today,
there
no
clear
classification
definition
this
condition,
termed
or
post-COVID-19
condition.
heterogeneity
led
groups/clusters
patients,
which
could
exhibit
different
risk
factors
Viral
persistence,
long-lasting
inflammation,
immune
dysregulation,
autoimmune
reactions,
reactivation
latent
infections,
endothelial
dysfunction
alteration
gut
microbiota
have
been
proposed
as
potential
mechanisms
explaining
complexity
long-COVID.
such
equation,
viral
biology
(e.g.,
re-infections,
variants),
host
genetics,
epigenetics)
external
vaccination)
should
also
considered.
These
various
will
discussed
current
directions
suggested.
Current HIV/AIDS Reports,
Год журнала:
2023,
Номер
20(2), С. 51 - 75
Опубликована: Янв. 21, 2023
Abstract
Purpose
of
Review
HIV/AIDS
and
COVID-19
have
been
the
major
pandemics
overwhelming
our
times.
Given
enduring
immune
disfunction
featuring
people
living
with
HIV
(PLWH)
despite
combination
antiretroviral
therapy
(cART),
concerns
for
higher
incidence
severity
SARS-CoV-2
infection
as
well
suboptimal
responses
to
newly
developed
vaccines
in
this
population
arose
early
during
pandemics.
Herein,
we
discuss
complex
interplay
between
SARS-CoV-2,
a
special
focus
on
natural
vaccination
PLWH.
Recent
Findings
Overall,
current
literature
shows
that
outcomes
may
be
worse
or
lower
PLWH
poor
CD4
+
T-cell
counts
and/or
uncontrolled
viremia.
Data
regarding
risk
post-acute
sequelae
(PASC)
among
are
extremely
scarce,
yet
they
seem
suggest
such
condition.
Summary
Scarce
immunovirological
control
appears
driver
weak
infection/vaccination
Therefore,
individuals
should
prioritized
receive
additional
vaccine
doses.
Furthermore,
given
potentially
developing
long-term
sequelae,
who
experienced
ensured
more
careful
prolonged
follow-up.
Pain Practice,
Год журнала:
2023,
Номер
24(1), С. 120 - 159
Опубликована: Июль 21, 2023
Abstract
Introduction
Individuals
recovering
from
acute
COVID‐19
episodes
may
continue
to
suffer
various
ongoing
symptoms,
collectively
referred
as
Long‐COVID.
Long‐term
pain
symptoms
are
amongst
the
most
common
and
clinically
significant
be
reported
for
this
post‐COVID‐19
syndrome.
Objectives
This
systematic
review
meta‐analysis
aimed
evaluate
proportions
of
persisting
experienced
by
individuals
past
phase
identify
their
associated
functional
consequences
inflammatory
correlates.
Methods
Two
online
databases
were
systematically
searched
inception
until
31
March
2022.
We
primary
research
articles
in
English,
which
evaluated
after
laboratory‐confirmed
resolution
specifically
on
and/or
outcomes.
Results
Of
611
identified
articles,
26
included,
used
data
extraction,
assessed
methodological
quality
risk
bias
two
independent
reviewers.
Pain
grouped
under
one
six
major
domains,
serving
our
co‐outcomes.
Proportional
meta‐analyses
pooled
logit‐transformed
values
single
performed
using
random‐effects‐restricted
maximum‐likelihood
model.
An
estimated
8%,
6%,
18%,
17%,
12%
continued
report
persistence
chest,
gastrointestinal,
musculoskeletal
joint,
muscle,
general
body,
nervous
system‐related
respectively,
up
year
COVID‐19.
Considerable
levels
heterogeneity
demonstrated
across
all
results.
Functional
quality‐of‐life
impairments
some
biomarker
elevations
with
long‐COVID
symptoms.
Conclusion
study's
findings
suggest
that
although
not
well
characterized,
being
non‐negligible
those
episodes,
thus
highlighting
importance
future
efforts
focus
aspect.
Turkish Journal of Physical Medicine and Rehabilitation,
Год журнала:
2023,
Номер
1(1), С. 1 - 7
Опубликована: Фев. 28, 2023
The
worldwide
pandemic
of
coronavirus
disease
2019
(COVID-19)
was
known
to
predominantly
affect
the
lungs,
but
it
realized
that
COVID-19
had
a
large
variety
clinical
involvement.
Cardiovascular,
gastrointestinal,
neurological,
and
musculoskeletal
systems
are
involved
by
direct
or
indirect
mechanisms
with
various
manifestations.
involvement
can
manifest
during
infection,
due
medications
used
for
treatment
COVID-19,
in
post/long
syndrome.
major
symptoms
fatigue,
myalgia/arthralgia,
back
pain,
low
chest
pain.
During
last
two
years,
increased,
no
clear
consensus
obtained
about
pathogenesis.
However,
there
is
valuable
data
supports
hypothesis
angiotensinconverting
enzyme
2,
inflammation,
hypoxia,
muscle
catabolism.
Additionally,
were
also
have
adverse
effects,
such
as
corticosteroid-induced
myopathy
osteoporosis.
Therefore,
while
deciding
drugs,
priorities
benefits
should
be
taken
into
consideration.
Symptoms
begin
three
months
from
onset
continue
at
least
months,
cannot
explained
another
diagnosis
accepted
Prior
may
persist
fluctuate,
new
manifest.
In
addition,
must
one
symptom
infection.
Most
common
myalgia,
arthralgia,
weakness,
sarcopenia,
impaired
exercise
capacity,
physical
performance.
female
sex,
obesity,
elderly
patients,
hospitalization,
prolonged
immobility,
having
mechanical
ventilation,
not
vaccination,
comorbid
disorders
predictors
Musculoskeletal
pain
problem
tends
chronic
form.
There
on
mechanism,
inflammation
angiotensin-converting
2
seem
play
an
important
role.
Localized
generalized
occur
after
general
localized
An
accurate
allows
physicians
initiate
management
proper
rehabilitation
programs.
Blood Reviews,
Год журнала:
2023,
Номер
60, С. 101075 - 101075
Опубликована: Март 20, 2023
ME/CFS
is
a
debilitating
chronic
condition
that
often
develops
after
viral
or
bacterial
infection.
Insight
from
the
study
of
Long
COVID/Post
Acute
Sequelae
COVID-19
(PASC),
post-viral
syndrome
associated
with
SARS-CoV-2
infection,
might
prove
to
be
useful
for
understanding
pathophysiological
mechanisms
ME/CFS.
Disease
presentation
similar
between
two
conditions,
and
subset
COVID
patients
meet
diagnostic
criteria
Since
characterized
by
significant
vascular
pathology
–
including
endothelial
dysfunction,
coagulopathy,
dysregulation
question
whether
not
same
biological
abnormalities
are
significance
in
arises.
Cardiac
have
while
now
been
documented
cohorts,
recent
studies
demonstrating
major
deficits
cerebral
blood
flow,
hence
dysregulation.
A
growing
body
research
accompanied
platelet
hyperactivation,
anomalous
clotting,
procoagulant
phenotype,
dysfunction.
Endothelial
damage
dysregulated
clotting
can
impair
substance
exchange
tissues,
result
hypoperfusion,
which
may
contribute
manifestation
certain
symptoms.
Here
we
review
literature
summarize
cardiovascular
haematological
findings
condition,
and,
this
context,
briefly
discuss
potential
role
previously-implicated
pathogens.
Overall,
cardiac
present
within
cohorts.
While
atherosclerotic
heart
disease
significantly
ME/CFS,
suboptimal
function
defined
reduced
output,
impaired
are,
these
do
appear
influenced
deconditioning.
Rather,
dysfunction
(autonomic)
nervous
system.
Plenty
recently
published
hyperactivity
as
well
processes.
It
particular
importance
determine
what
extent
symptom
severity,
if
systems
targeted
therapeutic
purposes.
Viral
reservoirs
herpesviruses
exist
most
likely
directly
indirectly.
This
highlights
studying
functioning,
vasculature,
coagulation
system
