Fundamental and Targeted Approaches in Pulmonary Arterial Hypertension Treatment

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 224 - 224

Опубликована: Фев. 10, 2025

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease marked by vascular remodeling, inflammation, smooth muscle cell proliferation, with limited treatment options focused primarily on symptom management. The multifactorial nature of PAH, encompassing genetic, autoimmune, connective tissue contributions, complicates its treatment, while irreversible changes, such as fibrosis, remain unaddressed current therapies. Fundamental research molecular pathways targeted delivery systems has paved the way for advanced therapeutic strategies that aim to modify progression rather than merely manage symptoms. Nanoparticle-based drug systems, leveraging controlled release pulmonary targeting, offer promising avenue overcome these challenges. Such enable precise localization vasculature, minimize systemic side effects, support emerging approaches like gene therapy combination treatments. Future should focus refining nanoparticle formulations personalized medicine, optimizing inhalation integrating multi-target achieve curative outcomes in PAH. This review explores pathophysiology pharmacological strategies, innovative nanoparticle-based therapies, emphasizing their potential transform PAH address underlying mechanisms.

Язык: Английский

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Novel copolymers of poly(sebacic anhydride) and poly(ethylene glycol) as azithromycin carriers to the lungs

Journal of Applied Biomedicine, Год журнала: 2025, Номер 45(1), С. 114 - 136

Опубликована: Янв. 1, 2025

Язык: Английский

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Impact of gold and silver nanoparticles injected in blood with viscous dissipation

Computer Methods in Biomechanics & Biomedical Engineering, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Май 1, 2025

A nano-blood model is developed to study the flow of gold- and silver-infused blood through a porous, stenotic artery under Newtonian assumptions. Wall curvature, convective heating, wall motion, viscous dissipation are considered. Darcy's simulates porous resistance, Tiwari-Das captures nanoparticle effects. Governing equations reduced via similarity transformations solved using MATLAB's bvp4c solver. Validation against existing studies provided. Results show gold-blood nanofluid achieves higher velocities than silver-blood. Increasing Biot number enhances cooling at arterial wall. Detailed graphs 3D contour plots illustrate effects on temperature, velocity, skin friction, Nusselt number.

Язык: Английский

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Quality by Design in Pulmonary Drug Delivery: A Review on Dry Powder Inhaler Development, Nanotherapy Approaches, and Regulatory Considerations

AAPS PharmSciTech, Год журнала: 2024, Номер 25(6)

Опубликована: Авг. 2, 2024

Язык: Английский

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“Nano-in-Micro” Structured Dry Powder Inhalers for pulmonary delivery: Advances and challenges

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105648 - 105648

Опубликована: Апрель 6, 2024

Язык: Английский

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Development and in vitro-in vivo performances of an inhalable andrographolide dry powder to target pulmonary inflammation

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 102, С. 106367 - 106367

Опубликована: Ноя. 7, 2024

Язык: Английский

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