Cited by Development and in vitro-in vivo performances of an inhalable andrographolide dry powder to target pulmonary inflammation

Fundamental and Targeted Approaches in Pulmonary Arterial Hypertension Treatment DOI

Ji Su Park,

Yong Hwan Choi,

Ji-Young Min

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 224 - 224

Published: Feb. 10, 2025

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease marked by vascular remodeling, inflammation, smooth muscle cell proliferation, with limited treatment options focused primarily on symptom management. The multifactorial nature of PAH, encompassing genetic, autoimmune, connective tissue contributions, complicates its treatment, while irreversible changes, such as fibrosis, remain unaddressed current therapies. Fundamental research molecular pathways targeted delivery systems has paved the way for advanced therapeutic strategies that aim to modify progression rather than merely manage symptoms. Nanoparticle-based drug systems, leveraging controlled release pulmonary targeting, offer promising avenue overcome these challenges. Such enable precise localization vasculature, minimize systemic side effects, support emerging approaches like gene therapy combination treatments. Future should focus refining nanoparticle formulations personalized medicine, optimizing inhalation integrating multi-target achieve curative outcomes in PAH. This review explores pathophysiology pharmacological strategies, innovative nanoparticle-based therapies, emphasizing their potential transform PAH address underlying mechanisms.

Language: Английский

Citations

Novel copolymers of poly(sebacic anhydride) and poly(ethylene glycol) as azithromycin carriers to the lungs DOI

Konrad Kwiecień, Karolina Knap, Rick Heida

et al.

Journal of Applied Biomedicine, Journal Year: 2025, Volume and Issue: 45(1), P. 114 - 136

Published: Jan. 1, 2025

Language: Английский

Citations

Impact of gold and silver nanoparticles injected in blood with viscous dissipation DOI

Haris Alam Zuberi, Madan Lal,

Shivangi Verma

et al.

Computer Methods in Biomechanics & Biomedical Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: May 1, 2025

A nano-blood model is developed to study the flow of gold- and silver-infused blood through a porous, stenotic artery under Newtonian assumptions. Wall curvature, convective heating, wall motion, viscous dissipation are considered. Darcy's simulates porous resistance, Tiwari-Das captures nanoparticle effects. Governing equations reduced via similarity transformations solved using MATLAB's bvp4c solver. Validation against existing studies provided. Results show gold-blood nanofluid achieves higher velocities than silver-blood. Increasing Biot number enhances cooling at arterial wall. Detailed graphs 3D contour plots illustrate effects on temperature, velocity, skin friction, Nusselt number.

Language: Английский

Citations

Quality by Design in Pulmonary Drug Delivery: A Review on Dry Powder Inhaler Development, Nanotherapy Approaches, and Regulatory Considerations DOI

Ashish Dilip Sutar,

Rahul Kumar Verma, Rahul Shukla

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(6)

Published: Aug. 2, 2024

Language: Английский

Citations

“Nano-in-Micro” Structured Dry Powder Inhalers for pulmonary delivery: Advances and challenges DOI

Jinxue Cao,

Yuyi Xu,

Jian Zhang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105648 - 105648

Published: April 6, 2024

Language: Английский

Citations

Development and in vitro-in vivo performances of an inhalable andrographolide dry powder to target pulmonary inflammation DOI

Jinxue Cao,

Y. Xiu,

Siqi Wang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106367 - 106367

Published: Nov. 7, 2024

Language: Английский

Citations