PubMed,
Год журнала:
2023,
Номер
40(6), С. 1093 - 1101
Опубликована: Дек. 25, 2023
Rapid
and
accurate
identification
effective
non-drug
intervention
are
the
worldwide
challenges
in
field
of
depression.
Electroencephalogram
(EEG)
signals
contain
rich
quantitative
markers
depression,
but
whole-brain
EEG
acquisition
process
is
too
complicated
to
be
applied
on
a
large-scale
population.
Based
wearable
frontal
lobe
monitoring
device
developed
by
authors'
laboratory,
this
study
discussed
application
signal
depression
recognition
intervention.
The
technical
principle
commonly
used
devices
were
introduced.
Key
technologies
for
signals-based
existing
limitations
reviewed
discussed.
Finally,
closed-loop
brain-computer
music
interface
system
personalized
was
proposed,
further
This
review
paper
may
contribute
transformation
relevant
theories
from
basic
research
application,
advance
screening
intervention.如何实现快速准确的识别和有效的非药物干预是目前抑郁症领域亟待解决的难题。脑电信号蕴藏丰富的抑郁症定量标记，但全脑脑电信号的采集操作过程繁琐，不易应用于大规模人群。本文基于笔者课题组自主研发的可穿戴额叶脑电信号监测设备及其在抑郁症识别和干预中的应用展开讨论，介绍可穿戴脑电信号监测设备的技术原理和常见类型，综述基于可穿戴脑电信号的抑郁症识别关键技术及其存在的技术瓶颈。最后，本文提出一种面向抑郁症个性化干预的闭环脑机音乐接口系统，并进一步探讨了其所面临的技术挑战。本文有助于促进相关理论和技术从基础研究向应用转化，推动抑郁症筛查和个性化干预的进程。.
Clinics and Practice,
Год журнала:
2024,
Номер
14(3), С. 703 - 717
Опубликована: Апрель 23, 2024
(1)
Background:
The
aim
of
this
study
was
to
analyze
the
impact
pharmacogenetic-guided
antidepressant
therapy
on
12-month
evolution
intensity
depressive
symptoms
in
patients
with
recurrent
disorder
(RDD)
comparison
a
control
group
subjects
who
were
treated
conventionally.
(2)
Methods:
This
prospective
longitudinal
conducted
between
2019
and
2022,
evaluated
by
employing
Hamilton
Depression
Rating
Scale
(HAM-D),
Anxiety
(HAM-A)
Clinical
Global
Impressions
Scale:
Severity
Improvement.
We
followed
them
up
at
1,
3,
6,
12
months.
(3)
Results:
Of
76
RDD,
37
tested
genetically
(Group
A)
39
not
B).
Although
from
Group
A
had
statistically
significantly
more
severe
MDD
baseline
than
those
B
(p
<
0.001),
adjusting
their
according
genetic
testing,
they
progressive
substantial
reduction
severity
RDD
[F
=
74.334;
η2
0.674;
p
0.001],
indicating
association
results
provided
testing
(67.4%).
(4)
Conclusions:
In
poor
response
therapy,
pharmacogenetic
allows
for
treatment
adjustment,
resulting
constant
superior
depression
anxiety
symptoms.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 2054 - 2054
Опубликована: Сен. 10, 2024
Depression
presents
with
altered
energy
regulation
and
neural
plasticity.
Previous
electroencephalography
(EEG)
studies
showed
that
practice
in
learning
tasks
increases
power
beta
range
(13-30
Hz)
healthy
subjects
but
not
those
impaired
Here,
we
ascertain
whether
depression
alterations
of
spectral
activity
connectivity
before
after
a
task.
Molecules,
Год журнала:
2024,
Номер
29(13), С. 3053 - 3053
Опубликована: Июнь 27, 2024
Depression
and
anxiety
are
recognized
as
the
most
common
mental
diseases
worldwide.
New
approaches
have
considered
different
therapeutic
targets,
such
oxidative
stress
inflammation
process,
due
to
their
close
association
with
establishment
progression
of
diseases.
In
present
study,
we
evaluated
antioxidant
anti-inflammatory
activities
methanolic
extracts
plant
species
Background:
Depression
presents
with
altered
energy
regulation
and
neural
plasticity.
Previous
electroencephalography
(EEG)
studies
showed
that
practice
increases
power
in
beta
range
(13-30
Hz)
healthy
subjects
but
not
those
impaired
Here,
we
ascertain
whether
depression
alterations
of
spectral
activity
connectivity
before
after
practice.
Methods:
We
used
publicly
available
resting
state
EEG
(64
electrodes)
122
subjects.
Based
on
Beck
Inventory
(BDI)
score,
they
were
assigned
to
either
high
BDI
(hBDI,
BDI&gt;13,
N=46)
or
control
(CTL,
BDI&lt;7,
N=75)
group.
analyzed
activity,
theta-beta
theta-gamma
phase-amplitude
coupling
(PAC)
recorded
a
learning
task.
Results:
At
baseline,
compared
CTL,
hBDI
group
exhibited
greater
over
fronto-parietal
regions
gamma
right
parieto-occipital
area.
After
practice,
all
frequency
ranges
observed
only
CTL.
Theta-beta
PAC
the
task
Conclusions:
The
lack
substantial
post-task
growth
depressed
likely
represents
saturation
due
baseline
values.
speculate
inhibitory/excitatory
imbalance,
plasticity
mechanisms,
dysregulation
present
may
contribute
this
phenomenon.
