Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract BACKGROUND We sought to characterize the cognitive profile among individuals with mild impairment Lewy bodies (MCI‐LB) help guide future clinical criteria. METHODS Systematic review and meta‐analysis included MCI‐LB studies data from PubMed, Embase, Web of Science, PsycINFO (January 1990 March 2023). scores were compared controls, MCI due Alzheimer's disease (MCI‐AD), dementia (DLB) groups random‐effects models. RESULTS 26 2823 participants. Across all domains, group performed worse than controls better DLB. Compared MCI‐AD, in attention/processing speed ( g = –0.24, 95% confidence interval [CI]: –0.35, –0.12), attention/executive –0.42, CI: –0.56, –0.28); verbal immediate recall 0.37; 0.15, 0.59) delayed memory 0.40; 0.22, 0.58). DISCUSSION The profiles MCI‐AD are consistent established DLB AD. Neuropsychological assessment may be helpful differential diagnosis, even early states. Highlights a systematic for cognition (MCI‐LB). had attention, executive function, processing speed. recall. was on domains bodies. Studies used different tests there is need global efforts harmonization.

Язык: Английский

---

Movement Disorders

Опубликована: Янв. 1, 2025

---

DCARD checklist: A simple screening tool for Lewy body disease-related early symptoms in memory clinic

General Hospital Psychiatry, Год журнала: 2025, Номер 94, С. 66 - 73

Опубликована: Фев. 22, 2025

Язык: Английский

---

Demenzdiagnose mittels Biomarker – geht das?

neuroreha, Год журнала: 2025, Номер 17(01), С. 16 - 24

Опубликована: Март 1, 2025

---

Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 14, 2025

Objective The most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body (LBD), they have overlapping clinical symptoms. We aimed to define amounts cortical activation identify indicators brain function better distinguish between these aid diagnosis using functional near-infrared spectroscopy (fNIRS). Methods Oxygenated hemoglobin (HbO) concentrations the brains patients with AD LBD were detected fNIRS. Brain was assessed a verbal fluency task (VFT). Resting-state task-state activations investigated determine differences LBD. Blood samples analyzed relevant biomarkers. HbO variables compared Functional connectivity at rest correlations blood biomarkers analyzed. sensitivity specificity parameters for differentiating dementias evaluated areas under receiver operating characteristic (ROC) curves (AUCs). Results This study recruited 28 inpatients 25 Mean did not significantly differ resting state ( p > 0.05), whereas differed t = −3.449, 0.001) groups. during VFT, lower left temporal 0.031), right dorsolateral prefrontal 0.001), 0.011) cortices AD, than group. amyloid-β (Aβ) 42 levels higher group 0.023), more α-synuclein expressed 0.012). Correlation analysis cognition-related associated plasma Aβ level pre-motor supplementary motor cortex r −0.378; 0.005) glial fibrillary acidic protein (GFAP) pars triangularis 0.006) rest. Levels biomarker negatively correlated −0.329, 0.016) VFT. AUC combination multiple fNIRS individual cognitive or (AUC 0.9314). Conclusion characteristics measured can help from adults.

Язык: Английский

---

Advancements and Challenges in Artificial Intelligence for Lewy Body Disease Research: A Brief Survey

Lecture notes in computer science, Год журнала: 2025, Номер unknown, С. 141 - 153

Опубликована: Янв. 1, 2025

Язык: Английский

---

Dementia with Lewy bodies and Parkinson disease dementia — the same or different and is it important?

Nature Reviews Neurology, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Язык: Английский

---

Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract INTRODUCTION Males are disproportionately represented in dementia with Lewy bodies (DLB). Little is known regarding sex differences cognitive, neuropsychiatric, and motor features of the prodromal stage DLB. METHODS We used National Alzheimer's Coordinating Center longitudinal data to examine 120 males 23 females 2 years prior a clinical diagnosis RESULTS were more likely than present two or core DLB obtaining dementia. Rapid eye movement sleep behavior disorder, cognitive fluctuations, bradykinesia, rigidity common females. Neuropsychological test performance was similar between groups. DISCUSSION In DLB, exhibit greater number Core may fall short identifying at risk. Additional work needed better understand profile Highlights There presentation course neurodegenerative disease. Findings from Uniform Data Set suggest there symptoms. Females less demonstrate diagnosis. This information can help inform diagnostic criteria for

Язык: Английский

---

Lewy Body Dementia

CONTINUUM Lifelong Learning in Neurology, Год журнала: 2024, Номер 30(6), С. 1673 - 1698

Опубликована: Дек. 1, 2024

ABSTRACT OBJECTIVE Lewy body dementia (LBD) is an umbrella term describing two closely related conditions: Parkinson disease (PDD) and with bodies (DLB). LBD the second most common cause of neurodegenerative but often underrecognized in clinical practice. This review covers key epidemiologic, clinical, cognitive, behavioral, biomarker features discusses current treatment options. LATEST DEVELOPMENTS Indicative biomarkers improve ability to make a diagnosis include single-photon emission computed tomography (SPECT) dopamine system (brain) noradrenergic (cardiac), polysomnography. α-Synuclein–specific spinal fluid, skin, plasma, brain imaging are active development some available for use. Prodromal stages PDD DLB have been contextualized, diagnostic criteria published. An emerging theme whether integrated staging focusing on protein aggregation, rather than symptoms, may advance research efforts. ESSENTIAL POINTS cognitive impairment older adults subject significant delays treatment, increasing burden patients family care partners. Understanding use will recognition. Earlier detection also facilitate new therapeutics enrollment trials.

Язык: Английский

---

What is the future for dementia with Lewy bodies?

Journal of Neurology, Год журнала: 2024, Номер 272(1)

Опубликована: Дек. 12, 2024

Язык: Английский

---