The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies DOI Creative Commons
Kathryn A. Wyman‐Chick, Matthew J. Barrett, Michael J. Miller

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(4)

Published: Oct. 1, 2024

Language: Английский

Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis DOI Creative Commons
Kathryn A. Wyman‐Chick, Ece Bayram,

Stephanie Gravett

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract BACKGROUND We sought to characterize the cognitive profile among individuals with mild impairment Lewy bodies (MCI‐LB) help guide future clinical criteria. METHODS Systematic review and meta‐analysis included MCI‐LB studies data from PubMed, Embase, Web of Science, PsycINFO (January 1990 March 2023). scores were compared controls, MCI due Alzheimer's disease (MCI‐AD), dementia (DLB) groups random‐effects models. RESULTS 26 2823 participants. Across all domains, group performed worse than controls better DLB. Compared MCI‐AD, in attention/processing speed ( g = –0.24, 95% confidence interval [CI]: –0.35, –0.12), attention/executive –0.42, CI: –0.56, –0.28); verbal immediate recall 0.37; 0.15, 0.59) delayed memory 0.40; 0.22, 0.58). DISCUSSION The profiles MCI‐AD are consistent established DLB AD. Neuropsychological assessment may be helpful differential diagnosis, even early states. Highlights a systematic for cognition (MCI‐LB). had attention, executive function, processing speed. recall. was on domains bodies. Studies used different tests there is need global efforts harmonization.

Language: Английский

Citations

1
DCARD checklist: A simple screening tool for Lewy body disease-related early symptoms in memory clinic DOI
Koji Kasanuki,

Moto Nishiguchi,

Mikiko Hagiwara

et al.

General Hospital Psychiatry, Journal Year: 2025, Volume and Issue: 94, P. 66 - 73

Published: Feb. 22, 2025

Language: Английский

Citations

0
Demenzdiagnose mittels Biomarker – geht das? DOI
Stefan Teipel

neuroreha, Journal Year: 2025, Volume and Issue: 17(01), P. 16 - 24

Published: March 1, 2025

Citations

0
Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy DOI Creative Commons

Nairong Ruan,

Liang Ming, Yuehong Liu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Objective The most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body (LBD), they have overlapping clinical symptoms. We aimed to define amounts cortical activation identify indicators brain function better distinguish between these aid diagnosis using functional near-infrared spectroscopy (fNIRS). Methods Oxygenated hemoglobin (HbO) concentrations the brains patients with AD LBD were detected fNIRS. Brain was assessed a verbal fluency task (VFT). Resting-state task-state activations investigated determine differences LBD. Blood samples analyzed relevant biomarkers. HbO variables compared Functional connectivity at rest correlations blood biomarkers analyzed. sensitivity specificity parameters for differentiating dementias evaluated areas under receiver operating characteristic (ROC) curves (AUCs). Results This study recruited 28 inpatients 25 Mean did not significantly differ resting state ( p > 0.05), whereas differed t = −3.449, 0.001) groups. during VFT, lower left temporal 0.031), right dorsolateral prefrontal 0.001), 0.011) cortices AD, than group. amyloid-β (Aβ) 42 levels higher group 0.023), more α-synuclein expressed 0.012). Correlation analysis cognition-related associated plasma Aβ level pre-motor supplementary motor cortex r −0.378; 0.005) glial fibrillary acidic protein (GFAP) pars triangularis 0.006) rest. Levels biomarker negatively correlated −0.329, 0.016) VFT. AUC combination multiple fNIRS individual cognitive or (AUC 0.9314). Conclusion characteristics measured can help from adults.

Language: Английский

Citations

0
Advancements and Challenges in Artificial Intelligence for Lewy Body Disease Research: A Brief Survey DOI
Tiziana D’Alessandro, Claudio De Stefano, Francesco Fontanella

et al.

Lecture notes in computer science, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 153

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dementia with Lewy bodies and Parkinson disease dementia — the same or different and is it important? DOI
YuHong Fu, Glenda M. Halliday

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Language: Английский

Citations

0
Movement Disorders DOI
Ece Bayram

Published: Jan. 1, 2025

Citations

0
Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data DOI Creative Commons
Kathryn A. Wyman‐Chick, Tanis J. Ferman, Melissa J. Armstrong

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract INTRODUCTION Males are disproportionately represented in dementia with Lewy bodies (DLB). Little is known regarding sex differences cognitive, neuropsychiatric, and motor features of the prodromal stage DLB. METHODS We used National Alzheimer's Coordinating Center longitudinal data to examine 120 males 23 females 2 years prior a clinical diagnosis RESULTS were more likely than present two or core DLB obtaining dementia. Rapid eye movement sleep behavior disorder, cognitive fluctuations, bradykinesia, rigidity common females. Neuropsychological test performance was similar between groups. DISCUSSION In DLB, exhibit greater number Core may fall short identifying at risk. Additional work needed better understand profile Highlights There presentation course neurodegenerative disease. Findings from Uniform Data Set suggest there symptoms. Females less demonstrate diagnosis. This information can help inform diagnostic criteria for

Language: Английский

Citations

0
Lewy Body Dementia DOI
James E. Galvin

CONTINUUM Lifelong Learning in Neurology, Journal Year: 2024, Volume and Issue: 30(6), P. 1673 - 1698

Published: Dec. 1, 2024

ABSTRACT OBJECTIVE Lewy body dementia (LBD) is an umbrella term describing two closely related conditions: Parkinson disease (PDD) and with bodies (DLB). LBD the second most common cause of neurodegenerative but often underrecognized in clinical practice. This review covers key epidemiologic, clinical, cognitive, behavioral, biomarker features discusses current treatment options. LATEST DEVELOPMENTS Indicative biomarkers improve ability to make a diagnosis include single-photon emission computed tomography (SPECT) dopamine system (brain) noradrenergic (cardiac), polysomnography. α-Synuclein–specific spinal fluid, skin, plasma, brain imaging are active development some available for use. Prodromal stages PDD DLB have been contextualized, diagnostic criteria published. An emerging theme whether integrated staging focusing on protein aggregation, rather than symptoms, may advance research efforts. ESSENTIAL POINTS cognitive impairment older adults subject significant delays treatment, increasing burden patients family care partners. Understanding use will recognition. Earlier detection also facilitate new therapeutics enrollment trials.

Language: Английский

Citations

1
What is the future for dementia with Lewy bodies? DOI

Bianca Palushaj,

Simon J.G. Lewis, Carla Abdelnour

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 272(1)

Published: Dec. 12, 2024

Language: Английский

Citations

0