Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review

Ophthalmology and Therapy, Год журнала: 2023, Номер 12(2), С. 755 - 788

Опубликована: Фев. 18, 2023

Exposure to blue light has seriously increased in our environment since the arrival of emitting diodes (LEDs) and, recent years, proliferation digital devices rich light. This raises some questions about its potential deleterious effects on eye health. The aim this narrative review is provide an update ocular and discuss efficiency methods protection prevention against light-induced injury. search relevant English articles was conducted PubMed, Medline, Google Scholar databases until December 2022. Blue exposure provokes photochemical reactions most tissues, particular cornea, lens, retina. In vitro vivo studies have shown that certain exposures (depending wavelength or intensity) can cause temporary permanent damage structures eye, especially However, currently, there no evidence screen use LEDs normal are human Regarding protection, currently a beneficial effect blocking lenses for diseases, age-related macular degeneration (AMD). humans, pigments (composed lutein zeaxanthin) represent natural by filtering light, be through intake from foods food supplements. These nutrients associated with lower risk AMD cataract. Antioxidants such as vitamins C, E, zinc might also contribute preventing oxidative stress. Currently, at domestic intensity levels retinotoxic eye. toxicity long-term cumulative dose-response unknown.

Язык: Английский

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Efficacy of Repeated Low-Level Red-Light Therapy for Slowing the Progression of Childhood Myopia: A Systematic Review and Meta-analysis

American Journal of Ophthalmology, Год журнала: 2023, Номер 252, С. 153 - 163

Опубликована: Апрель 7, 2023

Язык: Английский

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Advances in myopia control strategies for children

British Journal of Ophthalmology, Год журнала: 2024, Номер unknown, С. bjo - 323887

Опубликована: Май 22, 2024

Myopia has long been a global threat to public health. Timely interventions are likely reduce the risk of vision-threatening complications. There both established and rapidly evolving therapeutic approaches slow myopia progression and/or delay its onset. The effective methods for slowing include atropine eye-drops, defocus incorporated multiple segments (DIMS) spectacle lenses, lenses with highly aspherical lenslets target (HALT), diffusion optics technology (DOT) red light therapy (RLT), multifocal soft contact orthokeratology. Among these, 0.05% atropine, HALT RLT +3.00 peripheral addition yield over 60% reduction in progression, whereas DIMS, DOT MiSight demonstrate at least 50% control efficacy. demonstrates more optimal balance efficacy safety than 0.01%. 0.01% not consistent requires further validation across diverse ethnicities. Combining orthokeratology or DIMS spectacles yields better outcomes using these as monotherapies. Increased outdoor time is an health strategy prevention while recent studies suggest that low-concentration have promising potential clinical high-risk groups. being invasive, safe long-term use. However, when considering other approaches, it essential ensure proper instruction regular follow-ups maintain monitor any Ultimately, significant advances made strategies, many which shown meaningful outcomes. use adequate monitoring extended durations imperative foster confidence can only come from extensive experience.

Язык: Английский

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Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review

International Journal of Medical Sciences, Год журнала: 2023, Номер 20(10), С. 1363 - 1376

Опубликована: Янв. 1, 2023

Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application myopia.This revolution led RLRL therapy is due to significant advances bioenergetics photobiology, instance, enormous progresses photobiomodulation regulated cytochrome c oxidase, the primary photoreceptor of light red near infrared regions electromagnetic spectrum, mechanism action therapy.This oxidase also key mitochondrial enzyme bioenergetics, especially nerve cells retina brain.In addition, dopamine (DA)-enhanced release nitric oxide may be involved controlling myopia activation synthase, cGMP signaling.Recent evidence suggested that inhibit progression inhibiting spherical equivalent refraction (SER) axial elongation without adverse effects.In this review, we provide unique paradigm control support theory targeting neuronal metabolism constitute major target neurotherapeutics myopia, with emphasis on its molecular, cellular, nervous tissue levels, potential benefits myopia.

Язык: Английский

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Spatial frequency of environments and myopia: A systematic review on associated evidence and underlying mechanisms

Acta Ophthalmologica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract Purpose Previous animal studies have found a relationship between spatial frequency and myopia. New research in humans suggest that reduced high content of the visual environment may be contributing factor for myopia development. This study aims to review literature elucidate potential biological mechanisms linking Methods A systematic search was conducted across PubMed Web Science databases. The published from their inception August 2024 explored connection Only full‐text articles English were included. PRISMA used data validity. Results total 13 included this review, comprising seven model studies, four population‐based one pictorial analysis on design. Epidemiological evidence is comparatively limited has only begun emerge recent years. Mid‐ frequencies play an important role emmetropization process eye. Low can increase risk incidence. Furthermore, how affects are summarized as information processing characteristics, eye accommodation function movements, contrast sensitivity relevant molecules involved pathway. Conclusion suggests indoor related development Further warranted understand if incorporation changes environments helpful prevention control

Язык: Английский

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Interventions for myopia control in children: a living systematic review and network meta-analysis

Cochrane library, Год журнала: 2025, Номер 2025(2)

Опубликована: Фев. 13, 2025

Язык: Английский

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A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control

Investigative Ophthalmology & Visual Science, Год журнала: 2023, Номер 64(3), С. 31 - 31

Опубликована: Март 23, 2023

Purpose: To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) unrestricted vision (UnV) on lens-induced myopia (LIM) development in chickens. Methods: Myopia was induced one eye chicks (10 groups, n = 126) from day 1 posthatching (D1) until 8 (D8) using –10 diopter (D) lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to 2, 4, or 6 hours HL (15,000 lux), UnV (removal D lens), both (HL + UnV). One group served LIM without any interventions. Ocular axial length (AL), refractive error, choroidal thickness measured D1, D4, D8. Outcome measures are expressed interocular difference (IOD experimental – control eye) ± SEM. Results: By D8, increased AL (0.36 0.04 mm), myopic refraction (−9.02 0.37 D), thinning (−90.27 16.44 µm) (all, P < 0.001). Compared group, exposure HL, UnV, reduced a manner, with being more effective than (P 0.05). Only (not 2 4 hours) prevented 0.004) 0.001) reducing elongation. Conclusions: Daily manner completely stopped development. The effect is dependent duration

Язык: Английский

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The impact of lifestyle factors on myopia development: Insights and recommendations

Deleted Journal, Год журнала: 2024, Номер 1(1), С. 100010 - 100010

Опубликована: Апрель 1, 2024

This study evaluates the influence of various lifestyle factors, such as screen time, physical inactivity, dietary habits, and psychological stress, on development progression myopia in comparison to genetic predisposition. It underscores critical role adopting healthier lifestyles minimize risk myopia, especially genetically susceptible individuals. integrates a systematic review existing literature with empirical data assess relationship between habits providing nuanced understanding its multifaceted etiology. Comprehensive analysis from multiple institutional clinical studies. The includes research individuals across spectrum, examining factors addition influences. Analysis focused behaviors, including digital device use, activity, patterns, sleep quality relation myopia. Correlation prevalence choices susceptibility. results highlight strong association behaviors predispositions exacerbating effects detrimental habits. In particular, proactive modifications, increasing outdoor appear be effective preventing supports an integrative approach management, emphasizing modifications conjunction awareness. calls for comprehensive public health strategies address increase advocating balanced interplay maintaining health, engaging activities, promoting mental wellness counteract multifactorial risks associated development.

Язык: Английский

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Diurnal retinal and choroidal gene expression patterns support a role for circadian biology in myopia pathogenesis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 4, 2024

Abstract The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and clinical findings suggest an etiologic role for circadian rhythms in development, we assayed gene expression by RNA-Seq retina choroid at the onset unilateral experimental chick, isolating tissues every 4 h during a single 24-h period from myopic contralateral control eyes. Occluded versus open eye differences varied considerably over sampling period, with some occurring multiple times day others showing only investigated timepoint. Some genes identified or chick were previously as candidate common human myopia. Like differentially expressed genes, pathways Gene Set Enrichment Analysis also dramatically time. Considered other data, genetic epidemiology these further implicate events pathogenesis. present results emphasize need include time mechanistic studies assess biology directly trying understand better origin develop more effective therapies.

Язык: Английский

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Lower indoor spatial frequency increases the risk of myopia in children

British Journal of Ophthalmology, Год журнала: 2024, Номер unknown, С. bjo - 325888

Опубликована: Авг. 8, 2024

Animal models have shown that the absence of high-frequency visual information can precipitate onset myopia, but this relationship remains unclear in humans. This study aims to explore association between spatial frequency content environment and myopia children.

Язык: Английский

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