Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus
Computational and Structural Biotechnology Journal,
Год журнала:
2025,
Номер
27, С. 488 - 500
Опубликована: Янв. 1, 2025
Staphylococcus
aureus
(S.
aureus)
is
a
prevalent
pathogen
associated
with
wide
range
of
infections,
exhibiting
significant
antibiotic
resistance
and
posing
therapeutic
challenges
in
clinical
settings.
The
formation
biofilms
contributes
to
the
emergence
resistant
strains,
further
diminishing
efficacy
antibiotics.
This,
turn,
leads
chronic
recurrent
ultimately
increasing
healthcare
burden.
Consequently,
preventing
eliminating
has
become
critical
focus
management
research.
This
review
systematically
examines
mechanisms
underlying
biofilm
S.
its
contribution
resistance,
emphasizing
essential
roles
play
maintaining
structural
integrity
enhancing
resistance.
It
also
analyses
protective
that
fortify
against
antimicrobial
treatments.
Furthermore,
provides
comprehensive
overview
recent
innovations,
including
enzymatic
therapy,
nanotechnology,
gene
editing,
phage
therapy.
Emerging
strategies
present
novel
approaches
combat
biofilm-associated
infections
through
various
mechanisms.
discusses
advancements
these
therapies,
their
practical
application,
an
in-depth
analysis
each
strategy's
potential.
By
mapping
future
research
directions,
this
aims
refine
anti-biofilm
control
infection
progression
effectively
mitigate
recurrence.
Язык: Английский
Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 172 - 172
Опубликована: Янв. 15, 2025
The
pervasive
and
often
indiscriminate
use
of
antibiotics
has
accelerated
the
emergence
drug-resistant
bacterial
strains,
thus
presenting
an
acute
threat
to
global
public
health.
Despite
a
growing
acknowledgment
severity
this
crisis,
current
suite
strategies
mitigate
antimicrobial
resistance
remains
markedly
inadequate.
This
paper
asserts
paramount
need
for
swift
development
groundbreaking
provides
comprehensive
review
array
innovative
techniques
currently
under
scrutiny.
Among
these,
nano-antimicrobials,
antimicrobials
derived
from
ribosomal
proteins,
CRISPR/Cas-based
systems,
agents
that
undermine
bioenergetics,
polysaccharides
hold
particular
promise.
analysis
gives
special
attention
antimicrobials,
scrutinizing
their
underlying
mechanisms,
exploring
potential
applications,
delineating
distinct
advantages,
noting
likely
limitations.
Furthermore,
we
extend
our
exploration
by
proposing
theoretical
advancements
in
technology
evaluating
feasible
methods
effective
delivery
these
agents.
includes
leveraging
advances
broader
biomedical
potentially
revolutionizing
how
confront
pathogens
future,
laying
foundation
extended
research
multimodal
therapeutic
strategies.
Язык: Английский
Carbapenem-resistant hypervirulent Klebsiella pneumoniae: where is it headed in the tug-of-war between virulence and resistance?
EBioMedicine,
Год журнала:
2025,
Номер
114, С. 105649 - 105649
Опубликована: Март 10, 2025
Язык: Английский
Genome Editing: An Approach to Engineer Crops to Withstand Climate Change and Sustain Food Security
Опубликована: Янв. 1, 2025
Язык: Английский
Advancements in CRISPR-Cas-Based Strategies for Combating Antimicrobial Resistance
Microbiological Research,
Год журнала:
2025,
Номер
298, С. 128232 - 128232
Опубликована: Май 22, 2025
Язык: Английский
World Health Organisation’s Bacterial Pathogen Priority List (BPPL) 2017 and BPPL 2024 to combat global antimicrobial resistance crisis: ‘challenges and opportunities’
Journal of Antimicrobial Chemotherapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
Abstract
Antibiotic
resistance,
in
a
broader
perspective,
antimicrobial
resistance
(AMR)
presents
formidable
global
health
challenge,
threatening
the
effectiveness
of
antibiotics
and
other
agents.
As
result,
AMR
has
become
more
challenging
or
even
impossible
to
treat,
leading
increased
morbidity
mortality.
The
World
Health
Organisation
(WHO)
been
at
forefront
international
efforts
combat
by
sensitizing
world
about
pressing
need
tackle
save
future
human
race.
This
article
analyses
WHO’s
AMR,
including
creating
Bacterial
Pathogen
Priority
List
(BPPL),
developing
action
plan
address
promoting
surveillance
stewardship
programmes.
also
examines
progress
achieved
BPPL
2017
challenges
ahead
for
2024.
Additionally,
this
explores
various
through
two
major
approaches,
like
‘research
development’
‘the
policy
regulation-based’
approach.
underscores
emerging
strategies
example,
biofilm
disruption,
nanotechnology,
antibiotic
breakers,
antibody-antibiotic
conjugates,
rapid
detection
tools
alternative
therapies
phage
therapy,
peptides,
CRISPR-Cas
system,
probiotics
microbiota
modulations.
highlights
importance
coordinated
actions
sustained
commitment
safeguarding
public
ensuring
continued
therapies.
Язык: Английский