Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus DOI Creative Commons

Yi-qi Xia,

Zhenghui Hu,

Qiyuan Jin

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 488 - 500

Published: Jan. 1, 2025

Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation biofilms contributes to the emergence resistant strains, further diminishing efficacy antibiotics. This, turn, leads chronic recurrent ultimately increasing healthcare burden. Consequently, preventing eliminating has become critical focus management research. This review systematically examines mechanisms underlying biofilm S. its contribution resistance, emphasizing essential roles play maintaining structural integrity enhancing resistance. It also analyses protective that fortify against antimicrobial treatments. Furthermore, provides comprehensive overview recent innovations, including enzymatic therapy, nanotechnology, gene editing, phage therapy. Emerging strategies present novel approaches combat biofilm-associated infections through various mechanisms. discusses advancements these therapies, their practical application, an in-depth analysis each strategy's potential. By mapping future research directions, this aims refine anti-biofilm control infection progression effectively mitigate recurrence.

Language: Английский

Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria DOI Creative Commons

Junze Ma,

Zheng Lu

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 172 - 172

Published: Jan. 15, 2025

The pervasive and often indiscriminate use of antibiotics has accelerated the emergence drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment severity this crisis, current suite strategies mitigate antimicrobial resistance remains markedly inadequate. This paper asserts paramount need for swift development groundbreaking provides comprehensive review array innovative techniques currently under scrutiny. Among these, nano-antimicrobials, antimicrobials derived from ribosomal proteins, CRISPR/Cas-based systems, agents that undermine bioenergetics, polysaccharides hold particular promise. analysis gives special attention antimicrobials, scrutinizing their underlying mechanisms, exploring potential applications, delineating distinct advantages, noting likely limitations. Furthermore, we extend our exploration by proposing theoretical advancements in technology evaluating feasible methods effective delivery these agents. includes leveraging advances broader biomedical potentially revolutionizing how confront pathogens future, laying foundation extended research multimodal therapeutic strategies.

Language: Английский

Citations

0
Carbapenem-resistant hypervirulent Klebsiella pneumoniae: where is it headed in the tug-of-war between virulence and resistance? DOI Creative Commons
Meng Wang, Hui Wang

EBioMedicine, Journal Year: 2025, Volume and Issue: 114, P. 105649 - 105649

Published: March 10, 2025

Language: Английский

Citations

0
Genome Editing: An Approach to Engineer Crops to Withstand Climate Change and Sustain Food Security DOI
Othman Al‐Dossary

Published: Jan. 1, 2025

Language: Английский

Citations

0
Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus DOI Creative Commons

Yi-qi Xia,

Zhenghui Hu,

Qiyuan Jin

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 488 - 500

Published: Jan. 1, 2025

Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation biofilms contributes to the emergence resistant strains, further diminishing efficacy antibiotics. This, turn, leads chronic recurrent ultimately increasing healthcare burden. Consequently, preventing eliminating has become critical focus management research. This review systematically examines mechanisms underlying biofilm S. its contribution resistance, emphasizing essential roles play maintaining structural integrity enhancing resistance. It also analyses protective that fortify against antimicrobial treatments. Furthermore, provides comprehensive overview recent innovations, including enzymatic therapy, nanotechnology, gene editing, phage therapy. Emerging strategies present novel approaches combat biofilm-associated infections through various mechanisms. discusses advancements these therapies, their practical application, an in-depth analysis each strategy's potential. By mapping future research directions, this aims refine anti-biofilm control infection progression effectively mitigate recurrence.

Language: Английский

Citations

0