Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 2, 2025
Язык: Английский
BIOMETALS IN NEURODEGENERATIVE DISEASES: THEIR BENEFICIAL AND DETRIMENTAL ROLES IN BRAIN HEALTH.
TOBILOLA ODUNAYO AKINGBADE,
ELIJAH AYODELE OJO,
OPEYEMI PETER ADEBISI
и другие.
Greener Journal of Biomedical and Health Sciences,
Год журнала:
2025,
Номер
8(1), С. 16 - 27
Опубликована: Март 10, 2025
Biometals
are
essential
to
many
physiological
functions,
including
the
normal
functioning
and
development
of
brain.
Notably,
altered
levels
these
biometals
in
body
have
been
observed
patients
living
with
neurodegenerative
conditions
like
Alzheimer’s,
Huntington’s,
Parkinson’s,
Amyotrophic
Lateral
Sclerosis.
This
review
will
establish
how
can
enter
accumulate
mechanisms
for
exhibiting
neurotoxic
effects.
Correlations
between
level
other
non-essential
metals
existence
diseases
make
them
worthy
study.
Researchers
looked
toward
biometal
homeostasis
as
potential
sources
biomarkers,
diagnostic
breakthroughs,
therapeutic
solutions
conditions.
In
addition,
we
explore
benefit
brain
health,
their
role
conditions,
next
frontiers
biometal-based
diagnostics
therapy
research.
Язык: Английский
Recent advancements in the therapeutic approaches for Alzheimer's disease treatment: Current and future perspective
RSC Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
This
review
collates
the
recent
information
related
to
proposed
hypotheses
for
AD
etiology
and
advances
in
various
therapeutic
options,
with
a
particular
emphasis
on
clinical
candidates.
Язык: Английский
Emerging paradigms in Alzheimer's therapy
Agnes Preethy H.,
Kayalvizhi Rajendran,
Anitha Josephine Sukumar
и другие.
European Journal of Pharmacology,
Год журнала:
2024,
Номер
981, С. 176872 - 176872
Опубликована: Авг. 6, 2024
Язык: Английский
Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1585 - 1585
Опубликована: Дек. 23, 2024
Based
on
the
established
neuroprotective
properties
of
indole-based
compounds
and
their
significant
potential
as
multi-targeted
therapeutic
agents,
a
series
synthetic
indole–phenolic
was
evaluated
multifunctional
neuroprotectors.
Each
compound
demonstrated
metal-chelating
properties,
particularly
in
sequestering
copper
ions,
with
quantitative
analysis
revealing
approximately
40%
chelating
activity
across
all
compounds.
In
cellular
models,
these
hybrid
exhibited
strong
antioxidant
cytoprotective
effects,
countering
reactive
oxygen
species
(ROS)
generated
by
Aβ(25–35)
peptide
its
oxidative
byproduct,
hydrogen
peroxide,
showing
average
25%
increase
cell
viability
reduction
ROS
levels
to
basal
states.
Further
using
thioflavin
T
fluorescence
assays,
circular
dichroism,
computational
studies
indicated
that
synthesized
derivatives
effectively
promoted
self-disaggregation
fragment.
Taken
together,
findings
suggest
unique
profile
actions
for
derivatives,
combining
chelating,
antioxidant,
anti-aggregation
which
position
them
promising
development
agents
Alzheimer’s
disease
therapy.
The
methods
used
provide
reliable
vitro
data,
although
further
vivo
validation
assessment
blood–brain
barrier
penetration
are
needed
confirm
efficacy
safety.
Язык: Английский
X-ray Fluorescence Microscopy to Develop Elemental Classifiers and Investigate Elemental Signatures in BALB/c Mouse Intestine a Week after Exposure to 8 Gy of Gamma Rays
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10256 - 10256
Опубликована: Сен. 24, 2024
Iron
redistribution
in
the
intestine
after
total
body
irradiation
is
an
established
phenomenon.
However,
literature,
there
are
no
reports
about
use
of
X-ray
fluorescence
microscopy
or
equivalent
techniques
to
generate
semi-quantitative
2D
maps
iron
sectioned
samples
from
irradiated
mice.
In
this
work,
we
used
(XFM)
map
elemental
content
as
well
phosphorus,
sulfur,
calcium,
copper
and
zinc
tissue
sections
small
eight-week-old
BALB/c
male
mice
that
developed
gastrointestinal
acute
radiation
syndrome
(GI-ARS)
response
exposure
8
Gray
gamma
rays.
Seven
days
irradiation,
found
majority
localized
hot
spots
intercellular
regions
area
surrounding
crypts
stretching
between
outer
perimeter
surface
cell
layer
villi.
addition,
study
represents
our
current
efforts
develop
classifiers
could
be
for
automated
generation
interest
analyses
maps.
Once
developed,
such
a
tool
will
instrumental
studies
effects
other
toxicants
on
cells
tissues.
While
XFM
cannot
conducted
living
organisms,
it
possible
envision
future
scenarios
where
imaging
single
sloughed
human
(or
rodent)
follow
up
progression
GI-ARS.
Язык: Английский