Cannabis,
the
most
consumed
illicit
psychoactive
drug
in
world,
is
increasingly
used
by
pregnant
women.
However,
while
cannabinoid
receptors
are
expressed
early
embryo,
impact
of
phytocannabinoids
exposure
on
embryonic
processes
lacking.
Here,
we
leverage
a
stepwise
vitro
differentiation
system
that
captures
developmental
cascade
to
investigate
abundant
phytocannabinoid,
Δ9-tetrahydrocannabinol
(Δ9-THC).
We
demonstrate
Δ9-THC
increases
proliferation
naive
mouse
stem
cells
(ESCs)
but
not
their
primed
counterpart.
Surprisingly,
this
increased
proliferation,
dependent
CB1
receptor
binding,
only
associated
with
moderate
transcriptomic
changes.
Instead,
capitalizes
ESCs’
metabolic
bivalence
increasing
glycolytic
rates
and
anabolic
capabilities.
A
memory
rewiring
retained
throughout
Primordial
Germ
Cell-Like
Cells
absence
direct
an
alteration
transcriptional
profile.
These
results
represent
first
in-depth
molecular
characterization
stages
germline
development.
The Lancet Public Health,
Год журнала:
2025,
Номер
10(2), С. e148 - e159
Опубликована: Фев. 1, 2025
SummaryCannabis
consumption
is
legally
prohibited
in
most
countries
the
world.
Several
are
legalising
cannabis
for
adult
consumption.
It
important
to
monitor
public
health
effects
of
these
policy
changes.
In
this
paper,
we
summarise
evidence
date
on
legalisation
non-medical
use
Canada
and
USA.
We
describe
regulatory
models
legalisation,
changes
products
pricing,
illicit
market,
use,
cannabis-related
physical
mental
harms.
discuss
challenges
assessing
outcomes
emphasise
importance
continuous
rigorous
monitoring
adverse
inform
design
policies
regulations.
Cannabis,
the
most
consumed
illicit
psychoactive
drug
in
world,
is
increasingly
used
by
pregnant
women.
However,
while
cannabinoid
receptors
are
expressed
early
embryo,
impact
of
phytocannabinoids
exposure
on
embryonic
processes
lacking.
Here,
we
leverage
a
stepwise
vitro
differentiation
system
that
captures
developmental
cascade
to
investigate
abundant
phytocannabinoid,
Δ9-tetrahydrocannabinol
(Δ9-THC).
We
demonstrate
Δ9-THC
increases
proliferation
naive
mouse
stem
cells
(ESCs)
but
not
their
primed
counterpart.
Surprisingly,
this
increased
proliferation,
dependent
CB1
receptor
binding,
only
associated
with
moderate
transcriptomic
changes.
Instead,
capitalizes
ESCs'
metabolic
bivalence
increasing
glycolytic
rates
and
anabolic
capabilities.
A
memory
rewiring
retained
throughout
Primordial
Germ
Cell-Like
Cells
absence
direct
an
alteration
transcriptional
profile.
These
results
represent
first
in-depth
molecular
characterization
stages
germline
development.
Journal of Psychoactive Drugs,
Год журнала:
2023,
Номер
56(3), С. 342 - 352
Опубликована: Май 8, 2023
The
current
study
examined
whether
sex
moderates
associations
between
emotion
dysregulation
(overall
and
six
dimensions
of
dysregulation)
problematic
cannabis
use.
741
adult
past-month
users
(31.44%
female)
completed
questionnaires
on
use
(Marijuana
Problems
Scale)
(Difficulties
in
Emotion
Regulation
Scale).
Mann-Whitney
U
tests
hierarchical
multiple
linear
regressions
were
performed.
Male
reported
greater
difficulties
with
overall
dysregulation,
nonacceptance,
goals,
impulse,
strategies,
clarity.
Overall
strategies
associated
more
severe
use,
relationships
weaker
female
users.
Lack
emotional
awareness
was
less
male
only.
Examining
individual
differences
as
they
relate
to
suggests
that
treatments
may
need
be
tailored
for
a
focus
specific
dimensions.
Substance Use & Misuse,
Год журнала:
2024,
Номер
59(6), С. 962 - 970
Опубликована: Янв. 31, 2024
Purpose:
State-level
prevalence
data
are
used
to
investigate
whether
recreational
cannabis
legalization
moderates
the
mediated
pathway
from
perception
of
low
risk
harm,
use,
use
disorder
(CUD)
treatment
admissions,
among
adolescents
(age
12–17)
in
US.
Methods:
Annual
state
measures
risk,
and
CUD
admissions
between
2008
2019
(N
=
542
state-year
observations)
were
collected
National
Survey
on
Drug
Use
Health
(NSDUH)
Treatment
Episode
Dataset
–
Admissions
(TEDS-A).
A
two-way
fixed
effects
(state
year)
moderated
mediation
model
was
test
indirect
effect
via
use.
Results:
positive
perceiving
as
observed
prior
but
not
afterwards.
After
legalization,
association
with
strengthened,
suppressed,
compared
before
legalization.
Discussion:
Recreational
may
alter
social
acceptability
medical
self-administration
cannabis,
potentially
leading
utilization
decline
even
factors
for
increase.
Linking
advancing
awareness
health
risks
associated
adolescent
promoting
engagement
through
mHealth
approaches
primary
care
providers
key
addressing
potential
challenges
brought
about
by
expanding
JMIR Formative Research,
Год журнала:
2024,
Номер
8, С. e59088 - e59088
Опубликована: Сен. 2, 2024
Background
Delivering
prescription
digital
therapeutics
(ie,
evidence-based
interventions
designed
to
treat,
manage,
or
prevent
disorders
via
websites
smartphone
apps)
in
primary
care
could
increase
patient
access
substance
use
disorder
(SUD)
treatments.
However,
the
optimal
approach
implementing
remains
unknown.
Objective
This
pilot
study
is
a
precursor
larger
trial
test
whether
implementation
strategies
(practice
facilitation
[PF]
and
health
coaching
[HC])
improve
delivery
of
for
SUDs
care.
mixed
methods
describes
outcomes
among
patients
2
clinics
presents
qualitative
findings
on
implementation.
Methods
From
February
10
August
6,
2021,
total
3
mental
specialists
embedded
practices
same
integrated
system
were
tasked
with
offering
app-based
SUD.
In
first
half
pilot,
activities
included
training
supportive
tools.
PF
(at
1
clinic)
HC
clinics)
added
second
half.
All
analyses
relied
secondary
data,
including
electronic
records
therapeutic
vendor
data.
Primary
proportion
reached
by
fidelity
related
ideal
use.
We
used
assess
adherence
planned
barriers
facilitators
therapeutics.
Results
Of
all
18
prescribed
apps,
(56%)
downloaded
app
activated
their
prescription,
8
(44%)
completed
at
least
module
content.
Patients
who
per
week
average.
Ideal
(fidelity)
was
defined
as
completing
4
modules
having
monthly
SUD-related
visit;
(6%)
met
these
criteria
weeks
(of
12-week
period).
A
5
(28%)
had
prescriptions
while
available,
(11%)
successfully
contacted,
both
declined
coaching.
Clinicians
reported
competing
clinical
priorities,
technical
challenges,
logistically
complex
workflows
part
because
apps
required
prescription.
Some
impacted
staff
turnover
that
coincided
COVID-19
pandemic.
The
high
engagement
perception
meet
needs.
Conclusions
encountered
real-world
setting,
especially
staffing
shortages,
turnover,
priorities
clinic
teams.
randomized
will
clarify
extent
which
Trial
Registration
ClinicalTrials.gov
NCT04907045;
https://clinicaltrials.gov/study/NCT04907045
Journal of Addiction Medicine,
Год журнала:
2023,
Номер
17(6), С. 725 - 728
Опубликована: Авг. 29, 2023
This
study
investigates
whether
the
proportion
of
referrals
to
cannabis
use
disorder
(CUD)
treatment
from
criminal
justice
system
declined
among
adolescents
(aged
12-17
years)
and
young
adults
18-24
following
state
recreational
(adult
use)
legalization
in
United
States
between
2008
2019.Cannabis
referral
data
were
extracted
Treatment
Episode
Dataset-Admissions
used
calculate
trends
number
referrals.
Difference-in-differences
analysis
was
estimate
effect
on
state-level
as
a
share
all
admissions.Nationwide,
adolescent
adult
CUD
over
period.
The
significantly
more
rapidly
after
compared
with
before
(
β
=
-0.045;
95%
confidence
interval,
-0.079
-0.010;
P
0.01).
Among
adolescents,
trajectory
decline
did
not
change
-0.033;
-0.073
0.008;
0.11).The
is
likely
due
falling
cannabis-related
arrests.
Although
criminalization
may
result
court-mandated
for
some
without
CUD,
admissions
during
period
increasing
risk
factors
associated
represents
key
health
concern.
Promoting
screening
other
sources,
such
through
primary
care,
be
warranted.
Cannabis,
the
most
consumed
psychoactive
drug
in
world,
is
increasingly
used
by
pregnant
women.
However,
while
cannabinoid
receptors
are
expressed
early
embryo,
impact
of
phytocannabinoids
exposure
on
embryonic
processes
lacking.
Here,
we
leverage
a
stepwise
vitro
differentiation
system
that
captures
developmental
cascade
to
investigate
abundant
phytocannabinoid,
Δ9-tetrahydrocannabinol
(Δ9-THC).
We
demonstrate
Δ9-THC
increases
proliferation
naïve
mouse
stem
cells
(ESCs)
but
not
their
primed
counterpart.
Surprisingly,
this
increased
proliferation,
dependent
CB1
receptor
binding,
only
associated
with
moderate
transcriptomic
changes.
Instead,
capitalizes
ESCs’
metabolic
bivalence
increasing
glycolytic
rates
and
anabolic
capabilities.
A
memory
rewiring
retained
throughout
Primordial
Germ
Cell-Like
Cells
absence
direct
an
alteration
transcriptional
profile.
These
results
represent
first
in-depth
molecular
characterization
stages.
