Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner DOI Open Access
Sema G. Quadir,

Shane Zaidi,

M. G. Cone

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

ABSTRACT Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity high mortality among substance disorders. While there are currently three FDA-approved medications for treating AUDs, none specifically target the withdrawal/negative affect stage of AUD, underscoring need to understand underlying neurobiology during this critical addiction cycle. One key region involved in alcohol withdrawal negative prelimbic cortex, a subregion medial prefrontal cortex. previous studies have examined alcohol-related adaptations cortical principal glutamatergic neurons, here we used male female PV:Ai14, SOM:Ai14 VIP:Ai14 mice examine synaptic all major classes cortex interneurons following 72 hour from continuous access two bottle choice model EtOH drinking mice. We found that increased excitability PV males, but decreased VIP females. Additionally, reduced GABA release onto males while increasing glutamate In SOM interneurons, had no effect on excitability, males. Together, our identified sex-specific withdrawal-induced plasticity different types could provide insight into cellular substrates affective states withdrawal.

Язык: Английский

A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective DOI Creative Commons
Dylan Kirsch, Malia A. Belnap, Annabel Kady

и другие.

The American Journal of Drug and Alcohol Abuse, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Янв. 27, 2025

Background: There has been a dramatic rise in alcohol consumption and use disorder (AUD) among women. Recently, the field made substantial progress toward better understanding sex gender differences AUD. This research suggested accelerated progression to AUD associated health consequences women, phenomenon referred as "telescoping."Objective: To examine evidence for telescoping hypothesis from biopsychosocial perspective.Methods: narrative review examined integrated on biological, psychological, socio-environmental factors that may contribute development of women.Results: Biopsychosocial revealed sex- gender-specific risk pathways onset progression. Biological render females more vulnerable alcohol-related toxicity across various biological systems, including brain. Notably, are consistently observed neural circuitry underlying emotional stress regulation, hypothesized increase an internalizing pathway Psychological indicates women experience greater negative emotionality likely means alleviate emotions compared with men. Socio-environmental factors, such familial peer isolation, appear interact psychological processes way increases women.Conclusion: appears be complex interplay through pathway. Developing targeted interventions specifically target is critical.

Язык: Английский

Процитировано

1
Sex Differences in Alcohol Use: Is It All About Hormones? DOI Creative Commons
Xavier J. Maddern,

Lauren T Ursich,

Grace Bailey

и другие.

Endocrinology, Год журнала: 2024, Номер 165(9)

Опубликована: Июль 17, 2024

Risky alcohol use and disorders (AUD) are a rising problem in women, yet major disparity our understanding of what drives consumption women remains. Historically biomedical research has focused on male subjects; however, recent increases reporting females, have highlighted differences between the sexes. Here we review current literature effect gonadal steroid hormones (estrogens, androgens, progestins), neurosteriods, neurobiological factors clinical preclinical studies both Further, briefly discuss how fundamental sex genetics, metabolism, neuroimmune, stress responses may influence intake. Comparing sexes could aid discovery novel therapeutics to treat AUD, implementation treatment options women.

Язык: Английский

Процитировано

4
Naltrexone for Alcohol Use Disorder in Cirrhosis: Bridging the Gap in an Understudied Population DOI
Romina Vergara-Quispe, David Martí‐Aguado, Ramón Bataller

и другие.

Journal of Clinical and Experimental Hepatology, Год журнала: 2025, Номер 15(2), С. 102509 - 102509

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

0
EFFICACY OF MEDICATIONS FOR THE TREATMENT OF ALCOHOL USE DISORDER (AUD): A SYSTEMATIC REVIEW AND META-ANALYSIS CONSIDERING BASELINE AUD SEVERITY DOI Creative Commons
Roberta Agabio, Hugo López‐Pelayo, Pol Bruguera

и другие.

Pharmacological Research, Год журнала: 2024, Номер 209, С. 107454 - 107454

Опубликована: Окт. 11, 2024

Baseline severity of alcohol use disorder (AUD) is an influencing factor in the response to medications recommended for treatment AUD. The scarce efficacy AUD partly justifies their limited uses. We were interested evaluating approved and using generic inverse-variance, analysis facilitating comparison between placebo both at end study and, concomitantly, baseline values same participants. conducted a systematic review include randomized controlled trials (RCTs) comparing any medication providing, treatment, percent heavy drinking days (%HDD), (%DD), and/or drinks per day (DDD). searched PubMed, Embase, PMC, three CT registers from inception April 2023. A total 79 RCTs (11,737 participants; 30 different medications) included: 47 (8465 participants) used medications, 32 (3272 other medications. At baseline, participants consumed on average approximately 12 DDD, experienced 70 % DD, 61 HDD. Placebo halved or reduced these third. Compared placebo, further outcomes (moderate high certainty evidence). Other DDD without modifying outcomes. increased risk developing adverse events (high-certainty Despite large effects, our results support benefits providing people with AUD, helping them reduce consumption.

Язык: Английский

Процитировано

2
Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner DOI Open Access
Sema G. Quadir,

Shane Zaidi,

M. G. Cone

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

ABSTRACT Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity high mortality among substance disorders. While there are currently three FDA-approved medications for treating AUDs, none specifically target the withdrawal/negative affect stage of AUD, underscoring need to understand underlying neurobiology during this critical addiction cycle. One key region involved in alcohol withdrawal negative prelimbic cortex, a subregion medial prefrontal cortex. previous studies have examined alcohol-related adaptations cortical principal glutamatergic neurons, here we used male female PV:Ai14, SOM:Ai14 VIP:Ai14 mice examine synaptic all major classes cortex interneurons following 72 hour from continuous access two bottle choice model EtOH drinking mice. We found that increased excitability PV males, but decreased VIP females. Additionally, reduced GABA release onto males while increasing glutamate In SOM interneurons, had no effect on excitability, males. Together, our identified sex-specific withdrawal-induced plasticity different types could provide insight into cellular substrates affective states withdrawal.

Язык: Английский

Процитировано

0