Region-Specific Gene Expression Changes Associated with Oleoylethanolamide-Induced Attenuation of Alcohol Self-Administration DOI Open Access

Macarena González-Portilla,

Sandra Montagud‐Romero, Susana Mellado

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9002 - 9002

Опубликована: Авг. 19, 2024

Oleoylethanolamide (OEA) is a lipid with anti-inflammatory activity that modulates multiple reward-related behaviors. Previous studies have shown OEA treatment reduces alcohol self-administration (SA) while inhibiting alcohol-induced inflammatory signaling. Nevertheless, the specific mechanisms targets to achieve these effects not been widely explored. Here, we tested of during SA, extinction or previous cue-induced reinstatement seeking. In addition, measured gene expression changes in striatum and hippocampus relevant receptors for consumption (Drd1, Drd2, Cnr1, Oprm) as well immune-related proteins (Il-6, Il-1β, Tlr4) brain-derived neurotrophic factor (Bdnf). Our results confirmed when administered contingently, systemic administration reduced SA attenuated reinstatement. Interestingly, also observed number sessions needed Biochemical analyses showed induced dopamine cannabinoid hippocampus. modulated long-term immune response increased Bdnf expression. These suggest boosting levels may be an effective strategy reducing preventing relapse.

Язык: Английский

Sex and Gender Differences in Alcohol Use Disorder: Quo Vadis? DOI
Katie Witkiewitz, Lorenzo Leggio

Alcohol, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Процитировано

0
Rapid estrogen signaling drives binge drinking DOI
Xavier J. Maddern,

Lauren T Ursich,

Leigh C. Walker

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Therapeutic potential of faecal microbiota transplantation for alcohol use disorder, a narrative synthesis DOI

JOHN M. DOCHERTY

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111354 - 111354

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Region-Specific Gene Expression Changes Associated with Oleoylethanolamide-Induced Attenuation of Alcohol Self-Administration DOI Open Access

Macarena González-Portilla,

Sandra Montagud‐Romero, Susana Mellado

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9002 - 9002

Опубликована: Авг. 19, 2024

Oleoylethanolamide (OEA) is a lipid with anti-inflammatory activity that modulates multiple reward-related behaviors. Previous studies have shown OEA treatment reduces alcohol self-administration (SA) while inhibiting alcohol-induced inflammatory signaling. Nevertheless, the specific mechanisms targets to achieve these effects not been widely explored. Here, we tested of during SA, extinction or previous cue-induced reinstatement seeking. In addition, measured gene expression changes in striatum and hippocampus relevant receptors for consumption (Drd1, Drd2, Cnr1, Oprm) as well immune-related proteins (Il-6, Il-1β, Tlr4) brain-derived neurotrophic factor (Bdnf). Our results confirmed when administered contingently, systemic administration reduced SA attenuated reinstatement. Interestingly, also observed number sessions needed Biochemical analyses showed induced dopamine cannabinoid hippocampus. modulated long-term immune response increased Bdnf expression. These suggest boosting levels may be an effective strategy reducing preventing relapse.

Язык: Английский

Процитировано

1