Impact of dementia and mild cognitive impairment on bone health in older people DOI Creative Commons
Elizabeth M. Curtis, Màrio Miguel Rosa, Claire T. McEvoy

и другие.

Aging Clinical and Experimental Research, Год журнала: 2024, Номер 37(1)

Опубликована: Дек. 27, 2024

Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly global population, increasing in prevalence. These conditions closely associated, shared risk factors, underlying biological mechanisms potential direct causal pathways. In this review, epidemiological mechanistic links between mild skeletal health explored. Discussion will focus on how changes brain bone signalling can underly associations these conditions, consider molecular cellular drivers context inflammation gut microbiome. There is a complex interplay nutritional changes, which may precede or follow onset impairment (MCI) dementia, health. Polypharmacy patients MCI there difficult prescribing decisions to be made due elevated falls associated many drugs used for problems, consequently increase fracture risk. Some medications prescribed directly impact addition, have difficulty remembering medication without assistance, meaning that but not taken. Cognitive improved delayed by physical activity exercise, evidence additional benefits fractures. Research gaps priorities aim reducing burden fractures people also discussed.

Язык: Английский

Molecular mechanisms and therapeutic strategies of gut microbiota modulation in Sarcopenia (Review) DOI Open Access
Chengfu Yuan

Oncology Letters, Год журнала: 2024, Номер 29(3)

Опубликована: Дек. 17, 2024

Sarcopenia is an age-related disease that characterized by a decline in muscle mass and function with significant epidemiological clinical implications. In recent years, gut microbiota has gained attention as important regulatory factor human health. To the best of our knowledge, this first study to introduce definition background sarcopenia analyze potential impact on metabolism growth, including aspects such metabolites, protein synthesis energy metabolism. Additionally, article summarizes current research progress interventions for treatment sarcopenia, probiotics, prebiotics fecal transplantation discusses future directions therapeutic strategies.

Язык: Английский

Процитировано

0
Impact of dementia and mild cognitive impairment on bone health in older people DOI Creative Commons
Elizabeth M. Curtis, Màrio Miguel Rosa, Claire T. McEvoy

и другие.

Aging Clinical and Experimental Research, Год журнала: 2024, Номер 37(1)

Опубликована: Дек. 27, 2024

Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly global population, increasing in prevalence. These conditions closely associated, shared risk factors, underlying biological mechanisms potential direct causal pathways. In this review, epidemiological mechanistic links between mild skeletal health explored. Discussion will focus on how changes brain bone signalling can underly associations these conditions, consider molecular cellular drivers context inflammation gut microbiome. There is a complex interplay nutritional changes, which may precede or follow onset impairment (MCI) dementia, health. Polypharmacy patients MCI there difficult prescribing decisions to be made due elevated falls associated many drugs used for problems, consequently increase fracture risk. Some medications prescribed directly impact addition, have difficulty remembering medication without assistance, meaning that but not taken. Cognitive improved delayed by physical activity exercise, evidence additional benefits fractures. Research gaps priorities aim reducing burden fractures people also discussed.

Язык: Английский

Процитировано

0