International Journal of Environmental Research and Public Health,
Год журнала:
2020,
Номер
17(8), С. 2882 - 2882
Опубликована: Апрель 22, 2020
Objectives:
Amyotrophic
lateral
sclerosis
(ALS)
is
a
progressive
and
fatal
neurodegenerative
disease
with
still
unknown
etiology.
We
aimed
at
investigating
the
association
between
environmental
occupational
factors
ALS
risk.
Methods:
performed
population-based
case-control
study
in
four
Italian
provinces
(Catania,
Modena,
Novara,
Reggio
Emilia)
by
administration
of
tailored
questionnaires
to
cases
(n
=
95)
randomly
selected
population
referents
135).
estimated
risk
calculating
odds
ratio
(OR)
its
95%
confidence
interval
(CI)
using
an
unconditional
logistic
regression
model.
Results:
found
positive
for
history
occupation
agricultural
sector
(OR
2.09,
CI
0.79-7.54),
especially
longer
than
10
years
2.72,
1.02-7.20).
Overall
exposure
solvents
also
suggested
association,
thinners
2.27,
1.14-4.54)
paint
removers
2.01,
0.90-4.48).
Both
electromagnetic
fields
show
slightly
increased
OR
1.69
(95%
0.70-4.09)
2.41
1.13-5.12),
respectively.
Occupational
but
not
pesticides
1.22,
0.63-2.37),
particularly
fungicides,
metals
4.20,
1.88-9.38),
lead,
mercury,
selenium,
showed
imprecise
association.
Finally,
there
was
indication
living
proximity
water
bodies.
Conclusions:
Despite
caution
that
needs
be
used
due
some
limitations,
such
as
low
number
exposed
subjects
possibility
recall
bias,
these
results
suggest
potential
role
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(16)
Опубликована: Июнь 13, 2021
Abstract
Selenium
(Se)
is
an
essential
element
to
human
health
that
can
be
obtained
in
nature
through
several
sources.
In
the
body,
it
incorporated
into
selenocysteine,
amino
acid
used
synthesize
selenoproteins,
which
have
active
center
usually
dependent
on
presence
of
Se.
Although
Se
shows
beneficial
properties
health,
has
also
a
narrow
therapeutic
window,
and
therefore
excessive
intake
inorganic
organic
Se‐based
compounds
often
leads
toxicity.
Nanoparticles
based
(SeNPs)
are
less
toxic
than
They
both
biocompatible
capable
effectively
delivering
combinations
payloads
specific
cells
following
their
functionalization
with
targeting
ligands.
Herein,
main
origin
intake,
its
role
primary
biomedical
applications
revised.
Particular
focus
will
given
targets
explored
for
SeNPs
cancer
therapies,
discussing
different
methodologies
improve
stability,
while
enabling
extensive
delivery
drug‐loaded
SeNP
tumor
sites,
thus
avoiding
off‐target
effects.
Plant and Soil,
Год журнала:
2020,
Номер
453(1-2), С. 245 - 270
Опубликована: Июль 16, 2020
Selenium
(Se)
is
an
essential
element
for
mammals
and
its
deficiency
in
the
diet
a
global
problem.
Plants
accumulate
Se
thus
represent
major
source
of
to
consumers.
Agronomic
biofortification
intends
enrich
crops
with
order
secure
adequate
supply
by
people.The
goal
this
review
report
present
knowledge
distribution
processes
soil
at
plant-soil
interface,
behaviour
inside
plant
terms
biofortification.
It
aims
unravel
metabolic
pathways
that
affect
nutritional
value
edible
products,
various
strategies
challenging
environments,
as
well
impact
Se-enriched
food
on
human
health.Agronomic
breeding
are
prevalent
battling
deficiency.
Future
research
addresses
nanosized
biofortification,
crop
enrichment
multiple
micronutrients,
microbial-integrated
agronomic
optimization
adverse
conditions.
Biofortified
superior
quality
may
be
created,
enriched
healthy
Se-compounds,
several
other
valuable
phytochemicals.
Whether
such
might
used
intervention
recently
emerged
coronavirus
infections
relevant
question
deserves
investigation.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2633 - 2633
Опубликована: Янв. 30, 2023
Selenium
(Se)
is
a
naturally
occurring
metalloid
element
essential
to
human
and
animal
health
in
trace
amounts
but
it
harmful
excess.
Se
plays
substantial
role
the
functioning
of
organism.
It
incorporated
into
selenoproteins,
thus
supporting
antioxidant
defense
systems.
Selenoproteins
participate
metabolism
thyroid
hormones,
control
reproductive
functions
exert
neuroprotective
effects.
Among
elements,
has
one
narrowest
ranges
between
dietary
deficiency
toxic
levels.
Its
level
toxicity
may
depend
on
chemical
form,
as
inorganic
organic
species
have
distinct
biological
properties.
Over
last
decades,
optimization
population
intake
for
prevention
diseases
related
or
excess
been
recognized
pressing
issue
modern
healthcare
worldwide.
Low
selenium
status
associated
with
an
increased
risk
mortality,
poor
immune
function,
cognitive
decline,
dysfunction.
On
other
hand,
concentrations
slightly
above
its
nutritional
levels
shown
adverse
effects
broad
spectrum
neurological
increase
type-2
diabetes.
Comprehension
biochemical
pathways
under
normal
physiological
conditions
therefore
important
elucidate
effect
diseases.
This
review
gives
overview
highlighting
body.
The
activity
Se,
mainly
performed
through
epigenetic
discussed.
Moreover,
brief
phytoremediation
rhizofiltration
approaches
reported.
Following
a
request
from
the
European
Commission,
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
scientific
opinion
tolerable
upper
intake
level
(UL)
for
selenium.
Systematic
reviews
of
literature
were
conducted
identify
evidence
regarding
excess
selenium
clinical
effects
potential
biomarkers
effect,
risk
chronic
diseases
impaired
neuropsychological
development
in
humans.
Alopecia,
as
an
early
observable
feature
well-established
adverse
effect
exposure,
is
selected
critical
endpoint
which
base
UL
A
lowest-observed-adverse-effect-level
(LOAEL)
330
μg/day
identified
large
randomised
controlled
trial
humans
(the
Selenium
Vitamin
E
Cancer
Prevention
Trial
(SELECT)),
uncertainty
factor
1.3
applied.
255
established
adult
men
women
(including
pregnant
lactating
women).
ULs
children
are
derived
adults
using
allometric
scaling
(body
weight0.75).
Based
available
data,
consumers
unlikely
exceed
UL,
except
regular
users
food
supplements
containing
high
daily
doses
or
Brazil
nuts.
No
has
been
reported
with
current
levels
countries
(excluding
supplements)
toddlers
children,
arising
natural
content
foods
does
not
raise
reasons
concern.
Selenium-containing
should
be
used
caution,
based
individual
needs.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42696 - e42696
Опубликована: Фев. 1, 2025
Metals
have
been
used
for
many
centuries,
but
their
nutritional
and
toxic
effects
investigated
since
the
last
century.
The
common
heavy
metals
(THM)
include
mercury,
lead,
chromium
cadmium,
arsenic.
As
human
exposure
to
THM
increasingly
causes
systemic
organ
complications,
it
seems
required
review
recent
advances
of
treatment
metals.
Despite
current
knowledge
hazards
metals,
there
is
still
high
incidents
poisonings
particularly
in
developing
countries.
In
this
review,
after
an
introduction,
we
briefly
describe
routes
exposure,
clinical
features
prognosis
each
metal
poisoning.
Then,
different
treatments
with
particular
attention
both
acute
chronic
poisonings.
main
antidotes
all
are
chelating
agents,
new
agents
were
developed
over
past
decades
successfully
Dimercaptosuccinic
acid
(DMSA)
known
as
succimer
has
prescribed
a
safe
oral
chelator
lead
Similarly,
dimercapto-propanesulfonic
(DMPS)
also
revealed
fewer
side
than
old
agents.
two
currently
gaining
increased
acceptance
among
toxicologists.
However,
no
specific
antidote
mercury
Dimercaprol
almost
longer
choice
Comparison
management
intoxication
by
five
reveals
similar
strategies.
On
other
hand,
some
them
require
interventions
reduce
toxicity.
Because
drawbacks
application
commonly
bioactive
compounds
which
antioxidant
anti-inflammatory
properties
subject
much
interest
research.
despite
promising
results
observed
experimental
animals,
trials
on
therapeutic
benefits
not
yet
successful
need
further
studies
determine
efficacy
safety
humans.
Development
less
under
investigations.
Moreover,
development
orally
administrable
home
health
care
would
likely
be
great
future
