Annals of Medicine,
Год журнала:
2022,
Номер
54(1), С. 2258 - 2267
Опубликована: Авг. 17, 2022
Background
&
Objective
Selenium
was
one
of
the
essential
trace
elements
that
played
a
pivotal
role
in
human
health.
Although
previous
studies
have
investigated
relationship
between
selenium
and
non-alcoholic
fatty
liver
disease
(NAFLD)
fibrosis,
these
findings
were
still
inconclusive.
Our
study
aimed
to
explore
association
blood
level
NAFLD
advanced
fibrosis
diagnosed
by
vibration
controlled
transient
elastography
(VCTE)
US
adults.Methods
All
data
extracted
from
National
Health
Nutrition
Examination
Survey
database
(2017–2018).
Participants
divided
into
four
groups
according
quartile
level.
Liver
stiffness
attenuation
parameter
(CAP)
measured
VCTE.
Multiple
logistic
regression
models
subgroup
analyses
conducted
determine
variety
methods.Results
A
total
3336
participants
enrolled
main
analysis.
In
multiple
models,
higher
(>205.32,
≤453.62
μg/L)
had
significant
positive
with
(β
=
1.31).
Moreover,
high
significantly
inversely
0.61).
analysis,
correlation
found
males
Despite
dietary
intake
being
adjusted
or
different
subgroups,
associations
NAFLD/advanced
remained
significant.Conclusions
This
showed
positively
among
population.
lower
percentage
fibrosis.
Blood
is
more
likely
cause
due
imbalances
homeostasis
rather
than
intake.Key
messagesHigh
elastography.Participants
fibrosis.NAFLD
are
caused
an
imbalance
homeostasis,
not
intake.
Redox Biology,
Год журнала:
2022,
Номер
50, С. 102236 - 102236
Опубликована: Янв. 24, 2022
This
review
addresses
the
role
of
essential
trace
element,
selenium,
in
type-2
diabetes
mellitus
(T2DM)
and
its
metabolic
co-morbidities,
i.e.,
syndrome,
obesity
non-alcoholic
fatty
liver
disease.
We
refer
to
dietary
requirements
selenium
key
physiological
roles
selenoproteins.
explore
dysregulated
fuel
metabolism
T2DM
emphasizing
relevance
inflammation
oxidative
stress.
describe
epidemiology
observational
experimental
studies
related
conditions,
explaining
that
interaction
between
status
glucose
control
is
not
limited
hyperglycemia
but
extends
hypoglycemia.
propose
association
high
plasma/serum
T2DM/fasting
plasma
observed
many
cross-sectional
may
rely
on
upregulation
hepatic
selenoprotein-P
biosynthesis
conditions
insulin
resistance.
While
animal
have
revealed
potential
molecular
mechanisms
underlying
adverse
effects
severe
selenium/selenoprotein
excess
deficiency
pathogenesis
resistance
β-cell
dysfunction,
their
translational
significance
rather
limited.
Importantly,
supplementation
does
appear
be
a
major
causal
factor
for
development
humans
though
we
cannot
currently
exclude
small
contribution
top
other
risk
factors,
particular
if
it
ingested
at
(supranutritional)
doses.
Elevated
biomarkers
are
often
measured
patients
more
likely
consequence,
than
cause,
diabetes.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Март 21, 2022
Background
Systemic
immune-inflammation
index
(SII)
is
a
novel
inflammatory
marker,
and
inflammation
has
been
reported
to
be
related
with
renal
damage.
We
aimed
investigate
the
possible
relationship
between
SII
albuminuria.
Methods
The
present
cross-sectional
study
was
conducted
among
adults
complete
data
about
urinary
albumin-to-creatinine
ratio
(ACR)
in
2005–2018
National
Health
Nutrition
Examination
Survey
(NHANES).
calculated
as
platelet
count
×
neutrophil
count/lymphocyte
count.
Albuminuria
defined
ACR
>30mg/g.
Weighted
multivariable
regression
analysis
subgroup
were
explore
independent
Results
A
total
of
36,463
individuals
included
our
analysis;
9.56%
participants
categorized
having
albuminuria
overall
increased
higher
tertiles
(tertile
1,
7.83%;
tertile
2,
8.49%;
3,
12.13%;
p
for
trend
<0.0001).
Multivariable
logistic
showed
that
level
associated
likelihood
independently
(OR
=
1.31;
95%
CI,
1.17–1.48,
p<0.0001)
after
full
adjustment.
Subgroup
interaction
test
there
no
significant
dependence
gender,
age,
body
mass
index,
hypertension,
diabetes,
non‐alcoholic
fatty
liver
disease,
estimated
glomerular
filtration
rate
(eGFR)
on
this
positive
association
(all
>0.05).
Conclusions
positively
albumin
excretion
US
adults.
Further
large-scale
prospective
studies
are
still
needed
analyze
role
Following
a
request
from
the
European
Commission,
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
scientific
opinion
tolerable
upper
intake
level
(UL)
for
selenium.
Systematic
reviews
of
literature
were
conducted
identify
evidence
regarding
excess
selenium
clinical
effects
potential
biomarkers
effect,
risk
chronic
diseases
impaired
neuropsychological
development
in
humans.
Alopecia,
as
an
early
observable
feature
well-established
adverse
effect
exposure,
is
selected
critical
endpoint
which
base
UL
A
lowest-observed-adverse-effect-level
(LOAEL)
330
μg/day
identified
large
randomised
controlled
trial
humans
(the
Selenium
Vitamin
E
Cancer
Prevention
Trial
(SELECT)),
uncertainty
factor
1.3
applied.
255
established
adult
men
women
(including
pregnant
lactating
women).
ULs
children
are
derived
adults
using
allometric
scaling
(body
weight0.75).
Based
available
data,
consumers
unlikely
exceed
UL,
except
regular
users
food
supplements
containing
high
daily
doses
or
Brazil
nuts.
No
has
been
reported
with
current
levels
countries
(excluding
supplements)
toddlers
children,
arising
natural
content
foods
does
not
raise
reasons
concern.
Selenium-containing
should
be
used
caution,
based
individual
needs.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 15
Опубликована: Июль 6, 2022
Selenium
(Se),
in
the
form
of
selenoproteins,
is
an
essential
micronutrient
that
plays
important
role
human
health
and
disease.
To
date,
there
are
at
least
25
selenoproteins
humans
involved
a
wide
variety
biological
functions,
including
mammalian
development,
metabolic
progress,
inflammation
response,
chemoprotective
properties,
most
notably,
oxidoreductase
functions.
In
recent
years,
numerous
studies
have
reported
low
Se
levels
associated
with
increased
risk,
poor
outcome,
mortality
disorders,
mainly
related
to
limited
antioxidant
defense
resulting
from
deficiency.
Moreover,
correlation
between
deficiency
Keshan
disease
has
received
considerable
attention.
Therefore,
supplementation
as
therapeutic
strategy
for
preventing
occurrence,
delaying
progression,
alleviating
outcomes
some
diseases
been
widely
studied.
However,
supranutritional
serum
may
adverse
effects,
poisoning.
This
review
evaluates
status
health,
particular
emphasis
on
benefits
shedding
light
clinical
treatment.
Heliyon,
Год журнала:
2024,
Номер
10(4), С. e26023 - e26023
Опубликована: Фев. 1, 2024
The
augmented
prevalence
of
Se
(Se)
pollution
can
be
attributed
to
various
human
activities,
such
as
mining,
coal
combustion,
oil
extraction
and
refining,
agricultural
irrigation.
Although
is
vital
for
animals,
humans,
microorganisms,
excessive
concentrations
this
element
give
rise
potential
hazards.
Consequently,
numerous
approaches
have
been
devised
mitigate
pollution,
encompassing
physicochemical
techniques
bioremediation.
recognition
volatilization
a
strategy
mitigating
in
contaminated
environments
underscored
review.
This
study
delves
into
the
mechanisms
organisms,
including
plants,
microalgae,
microorganisms.
By
assessing
efficacy
removal
identifying
rate-limiting
steps
associated
with
volatilization,
paper
provides
insightful
recommendations
mitigation.
Constructed
wetlands
are
cost-effective
environmentally
friendly
alternative
treatment
volatilization.
fate,
behavior,
bioavailability,
toxicity
within
complex
environmental
systems
comprehensively
reviewed.
knowledge
forms
basis
developing
management
plans
that
aimed
at
contamination
protecting
ecosystems.
