Erectile function in men with COVID-19 six months after recovery DOI Creative Commons

E.V. Luchytskyi,

V.Ye. Luchytskyi, Galina Zubkova

и другие.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2024, Номер 19(8), С. 598 - 604

Опубликована: Янв. 9, 2024

Background. Based on the results of epidemiological studies, it was found that coronavirus disease 2019 (COVID-19) affects men more often than women. Among COVID-19 complications, erectile dysfunction is considered a marker endothelial and one main factors for development cardiovascular diseases. Lower total free testosterone levels are predictors adverse prognosis in males with severe acute respiratory syndrome 2 (SARS-CoV-2). Testosterone deficiency an independent risk factor cardiometabolic disorders. The purpose study to investigate state function who suffered from six months after recovery. Materials methods. Seventy-two suffering being treated infectious hospital were examined 6.90 ± 0.29 Their average age 45.23 3.01 years. control group included 18 conditionally healthy aged 43.18 2.90 assessed using International Index Erectile Function (IIEF). concentration determined by enzyme-linked immunosorbent assay DRG (Germany) DiaMetra (Italy) kits. All measurements performed Stat Fax 3200 analyzer. Statistical comparison obtained between groups according Student’s test. A value p < 0.05 be signifi­cant. Results. In addition dysfunction, as evidenced reduced corresponding integrative indicator “erectile function” IIEF-15 COVID-19, decrease sexual desire found, well deterioration sensations form ejaculation frequency orgasmic during sex contacts. serum level 10.9 nmol/l significantly compared group. Analysis individual indicators showed decreased 10 patients within normal range 13 COVID-19. 10.73 1.07 Conclusions. There confirmed probable score function. significant blood detected men, which may causes dysfunction. Large-scale prospective, randomized, controlled trials infected SARS-CoV-2 needed provide understanding molecular mechanisms cause

Язык: Английский

A systematic review on the correlation between COVID-19 and lower urinary tract symptoms DOI Creative Commons
Ashkan Shafigh,

Amir Mohammadi-Garebagh,

Kavous Shahsavarinia

и другие.

Journal of Clinical Virology Plus, Год журнала: 2025, Номер unknown, С. 100202 - 100202

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Expression of SARS-CoV-2 entry receptor ACE2 in human brain and its association with Alzheimer’s disease and COVID-19 DOI
Sijie Li, Jingyi Sun, He Li

и другие.

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Язык: Английский

Процитировано

0
Erectile dysfunction: the non-utilized role of exercise rehabilitation for the most embarrassing forgotten post-COVID complication in men DOI
Ali Mohamed Ali Ismail

The Aging Male, Год журнала: 2022, Номер 25(1), С. 217 - 218

Опубликована: Авг. 10, 2022

Язык: Английский

Процитировано

11
Causal associations between COVID-19 and erectile dysfunction: a Mendelian randomization study DOI Creative Commons
Chao Ma, Li Ma, Pu Wang

и другие.

Journal of International Medical Research, Год журнала: 2024, Номер 52(9)

Опубликована: Сен. 1, 2024

Objective In this study, we aimed to explore the potential association between COVID-19 infection, hospitalization, severe COVID-19, and erection dysfunction (ED) using two-sample Mendelian randomization (MR) method. Methods Data pertaining were extracted from latest version of Host Genetics Initiative genome-wide study (GWAS) meta-analyses (Round 7, April 2022), outcome data obtained Open GWAS database. We applied various MR analysis methods, including inverse variance weighted method, median MR-Egger regression. Results Our investigation revealed a negative causal hospitalization ED (total testosterone levels: beta = −0.026; 95% confidence interval: −0.049 −0.001). However, no evidence supported relationships for or other risk factors. Conclusion The results comprehensive suggest link total levels. Nonetheless, (comprising illness) may not directly correlate with an increased ED. These findings imply that exert distinct impact on through indirect pathways.

Язык: Английский

Процитировано

2
Genetic susceptibility to COVID ‐19 may increase the risk of erectile dysfunction: A two‐sample Mendelian randomization study DOI Open Access
Kun Zhang,

Hengxing Gao,

Mingwei Chen

и другие.

Andrologia, Год журнала: 2022, Номер 54(10)

Опубликована: Июль 12, 2022

Coronavirus disease 19 (COVID-19) and erectile dysfunction (ED) have been linked in some observational research, but the causality of this association European population is uncertain. Therefore, research intended to investigate susceptibility COVID-19 on ED. We used Mendelian randomization (MR) analysis for research. The subjects were from two genome-wide studies (GWAS) population, including (14,134 cases 1,284,876 controls) ED (6175 217,630 controls). utilized inverse variance-weighted (IVW) evaluate genetic Heterogeneity pleiotropy determined using Cochran's Q test MR-Egger regression. robustness findings was verified Leave-one-out method. obtained six single nucleotide polymorphisms (SNPs) as instrumental variables (IVs), there no significant pleiotropy, heterogeneity or bias these IVs. MR revealed elevated risk (ORIVW = 1.235, 95% CI: 1.044-1.462, p < 0.05). present study suggested among population. order decrease risk, ought positively prevent COVID-19.

Язык: Английский

Процитировано

9
Post-COVID Erectile Dysfunction: The Exercise May Be a Good Considered Complementary Choice DOI Creative Commons
Ali Mohamed Ali Ismail

American Journal of Men s Health, Год журнала: 2022, Номер 16(4)

Опубликована: Июль 1, 2022

Язык: Английский

Процитировано

7
Impact of the COVID-19 Pandemic on the Female Sexual Function Index and Female Behavioral Changes: A Cross-Sectional Survey Study in Thailand DOI Open Access
Udomsak Narkkul,

Jun Jiet Ng,

Apisith Saraluck

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(23), С. 15565 - 15565

Опубликована: Ноя. 23, 2022

Sexual health alterations are associated with disasters. Consequently, the COVID-19 pandemic may affect female sexual function. This study aimed to determine effect on function and know risk of dysfunction. online, cross-sectional, observational research was conducted during period. A logistic regression model used investigate associations between outcomes potential factors. In total, 432 sexually active women participating in region affected by were analyzed. The overall findings our that 60 percent females at for average FSFI score 21.27 ± 7.17. Comparing behavior before reveals a significant decrease frequency having sex per week, foreplay duration, coital duration. multivariate analysis, factors development RFSD age greater than 45 years (adjusted odds ratios (AOR) 15.09, 95% confidence interval (CI) 3.67–62.07), body mass index (BMI) 25 (AOR 3.26, 95%CI 1.23–8.67), jobs as healthcare provider 8.45, 3.66–19.53), previous infection within three months 36.81, 10.93–123.98), screened-positive anxiety 13.07, 4.75–35.94). influences increase dysfunction women. Concern effects quality life high-risk individuals is essential.

Язык: Английский

Процитировано

7
Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review DOI
Rashi Kulshrestha, Neelam Singla, Obaid Afzal

и другие.

Current Pharmaceutical Biotechnology, Год журнала: 2024, Номер 25(15), С. 1905 - 1914

Опубликована: Фев. 4, 2024

Erectile Dysfunction (ED) is a prevalent sexual health condition affecting significant portion of the male population worldwide. The conventional therapeutic approaches for ED often involve use pharmaceutical agents targeting phosphodiesterase-5 (PDE5) enzyme. Currently, treatment with PDE-5 inhibitors standard approach ED, and four inhibitors, namely sildenafil, vardenafil, tadalafil, avanafil, are in use. However, these interventions may be associated adverse effects limitations. As result, there has been growing interest exploring alternative complementary options such as nutraceuticals, which bioactive compounds derived from natural sources. Nutraceuticals, include vitamins, minerals, herbs, other dietary supplements, have gained popularity their potential benefits. Certain nutraceuticals demonstrated ability to modulate various physiological pathways, including those involved erectile function. A notable mechanism action inhibition PDE5 enzyme, plays pivotal role regulation cGMP levels. By inhibiting PDE5, can promote accumulation cGMP, leading enhanced penile blood flow improved comprehensive analysis literature showcases nutraceutical agents, plant-derived like flavonoids, polyphenols, amino acids exhibited inhibitory effects. Mechanistic insights into modulation NO release, elevation, relaxation smooth muscles, all critical factors achieving sustaining erections. This review focuses on elucidating treating dysfunction through

Язык: Английский

Процитировано

1
Updates in the pathophysiology of COVID-19 infection in male reproductive and sexual health: a literature review DOI Creative Commons
Meshari A. Alzahrani,

Khalid Alkhani,

Abdullah M. Alassaf

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Фев. 26, 2024

This extensive comprehensive review explores the impact of Coronavirus disease 2019 (COVID-19) pandemic on men’s sexual and reproductive health. We conducted a literature focusing possible pathophysiology by which severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) affects systems. reviewed most studies that reported SARS-CoV-2 infection Testicular, Epididymal, Prostatic, Penile tissue. Also, we focused evaluating semen parameters male hormones. Finally, COVID-19 vaccine’s effect Findings revealed adverse consequences at cellular organ levels genital tract. However, data are still controversial. The initial regarding vaccination was promising promoted safety for conclude this paper offering recommendations to address these potentially improve health among men in post-COVID-19 era.

Язык: Английский

Процитировано

1
An overview of conventional and investigational phosphodiesterase 5 inhibitors for treating erectile dysfunction and other conditions DOI
Ezzat A. Ismail, Ahmed I. El‐Sakka

Expert Opinion on Investigational Drugs, Год журнала: 2024, Номер 33(9), С. 925 - 938

Опубликована: Авг. 3, 2024

There is a rising concern about developing innovative, efficacious PDE5I molecules that provide better safety, efficacy, and tolerability with less adverse effects. Innovative dual targets have also been defined in the literature. Additionally, some of are able to selectively inhibit other enzymes such as histone deacetylase, acetylcholine esterase, cyclooxygenase or act nitric oxide donors. This review presents knowledge concerning advanced trends perspectives using treatment ED conditions.

Язык: Английский

Процитировано

1