Causal association between erectile dysfunction with urate levels and gout: a two-sample Mendelian randomization study DOI Creative Commons
Qingqiang Gao, Leilei Zhu,

Pan Chun-yan

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 28, 2023

Abstract Background A plethora of studies have demonstrated that the level uric acid (UA) and gout are risk factors for erectile dysfunction (ED). However, causal effect UA on ED is still unclear. Objectives This Mendelian randomization (MR) study aims to examine bidirectional causality between levels as well gout. Materials methods We performed a MR analysis using summary statistics from genome-wide association (GWAS) investigate meticulously selected single nucleotide polymorphisms (SNPs) based rigorous criteria instrumental variables. Four two-sample methods, including inverse-variance weighted (IVW), MR-Egger, median, mode, were applied in our study. Furthermore, several sensitivity analyses Cochrane's Q-test, MR-Egger intercept test, MR-PRESSO global leave-one-out assess heterogeneity, horizontal pleiotropy, stability. Results The included one dataset related (GWAS meta-analysis conducted by Tin et al.), two datasets (ukb-b-12765 finn-R9-M13_GOUT), Bovijn al.). results IVW method indicated not causally associated with three levels/gout-related (IVW, odds ratio [OR]: 0.99, 95% confidence interval [CI]: 0.92 − 1.07, P = 0.834; 3.20, 0.17–61.69, 0.441; 1.03, 0.97–1.09, 0.372, respectively). reverse revealed no evidence or according (OR: 95%CI: 0.96–1.02, P: 0,568; 1.00, 1.00–1.00, 0.555; 0.97, 0.89–1.05, 0.425, other consistent IVW. suggested robust, pleiotropy heterogeneity detected. Conclusion Our supports ED.

Язык: Английский

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction DOI Open Access
Giovanni Corona, Domenico Cucinotta, Giorgio Di Lorenzo

и другие.

Journal of Endocrinological Investigation, Год журнала: 2023, Номер 46(6), С. 1241 - 1274

Опубликована: Янв. 25, 2023

Язык: Английский

Процитировано

64
Future perspectives for PDE5 inhibitors bridging the gap between cardiovascular health and psychological status DOI Creative Commons
Andrea Sansone, Eugenia Guida, Susanna Dolci

и другие.

Basic and Clinical Andrology, Год журнала: 2025, Номер 35(1)

Опубликована: Янв. 26, 2025

Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking new discipline sexual medicine. Findings from number laboratories and clinics around world unanimously demonstrated following: (i) major cause ED is directly or indirectly related cardiovascular disease (CVD); (ii) CVDs share same risk factors, mainly lifestyle choices; (iii) first therapeutic approach both transform harmful lifestyles into virtuous lifestyles; (iv) PDE5is general, particularly very safe, if not protective, use CVD patients. However, has faced several challenges. Many patients some healthcare providers (HCPs) often misconception these drugs can CVD. Some might desire fulfill unmet need privacy linked stigma being treated be enticed by idea buying online, either because shame cheaper prices, without knowing risks associated with counterfeit drugs. aim this narrative revision current literature demonstrate orodispersible film sildenafil safe CV perspective; it discreet formulation respects privacy; virtually unique PDE5i too expensive produce outside correct channels, making impossible counterfeit.

Язык: Английский

Процитировано

2
Erectile dysfunction and premature ejaculation: a continuum movens supporting couple sexual dysfunction DOI Open Access
Giovanni Corona

Journal of Endocrinological Investigation, Год журнала: 2022, Номер 45(11), С. 2029 - 2041

Опубликована: Май 3, 2022

Язык: Английский

Процитировано

30
Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study DOI

D. G. Corona,

Walter Vena, Alessandro Pizzocaro

и другие.

Journal of Endocrinological Investigation, Год журнала: 2023, Номер 46(11), С. 2195 - 2211

Опубликована: Июль 29, 2023

Язык: Английский

Процитировано

20
Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility DOI Creative Commons

Xiaoqin Xin,

Qi Zhang, Jing Xu

и другие.

International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 33 - 42

Опубликована: Янв. 1, 2025

Background: Few studies have evaluated the correlation between serum uric acid (SUA) levels and prevalence of female infertility in general population, effect magnesium intake on this has not been investigated. Methods: All participants aged 18– 45 years at baseline were enrolled from National Health Nutritional Examination Surveys (NHANES) 2013– 2018. The continuous variable SUA was divided into quartile (Q1: ≤ 3.7 mg/dL, Q2: 3.7– 4.4 Q3: 4.4– 5.1 Q4: ≥ mg/dL). Multivariable logistic regression used to estimate odds ratios (OR) 95% confidence intervals (CI). Dietary two groups based median number (low intake, < 243 mg/day; high mg/day). Results: A total 3185 included final analysis, 10.58% whom infertile. In full adjustment model, positively associated with (OR=1.13, CI: 1.01– 1.27). Compared lowest (Q1), highest (Q4) had an increased risk by 62% (OR=1.62, 1.1– 2.4). Moreover, we found interactive association adjusted models (interaction likelihood ratio test: P=0.029), implying that may ameliorate infertility. Conclusion: This study is first report dietary relationship Plain Language Summary: Infertility affects approximately 15% reproductive-aged couples worldwide. population. role through its effects We present existed, which implied casts a light how infertility, hinting importance supplementing various ways. Keywords: acid, dietary,

Язык: Английский

Процитировано

1
Erectile Dysfunction and Oxidative Stress: A Narrative Review DOI Open Access

Dake Zhu,

Quan Minh Pham, Chunlin Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3073 - 3073

Опубликована: Март 27, 2025

Erectile dysfunction (ED) is a prevalent condition affecting male sexual health, characterized by the inability to achieve or maintain satisfactory erections. ED has multifactorial pathogenesis in which psychological, hormonal, neurologic, cardiovascular, and lifestyle factors all contribute progressive decline of erectile function. A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production antioxidant defenses, disrupts endothelial function, reduces nitric oxide (NO) bioavailability, contributes vascular dysfunction. This narrative review explores interplay OS ED, focusing on roles ROS sources such as NADPH oxidase, xanthine uncoupled synthase, mitochondrial It examines impact chronic conditions like hypertension, diabetes mellitus, hyperlipidemia, hypogonadism, smoking obesity, exacerbate through systemic effects. Emerging research underscores potential therapies interventions restore redox balance, improve mitigate ED's progression. also highlights gaps understanding molecular pathways linking emphasizing need for further develop targeted therapeutic strategies.

Язык: Английский

Процитировано

1
Infection, inflammation, and sexual function in male and female patients—recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024) DOI Creative Commons
Fernando Nestor Fácio, Elena Colonnello, Laith Alzweri

и другие.

Sexual Medicine Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Язык: Английский

Процитировано

1
The canary in the coal mine. Comment on “Association between cardiometabolic index and erectile dysfunction among US adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 2001–2004” DOI

Dimitri Yannas,

Andrea Sansone, Emmanuele A. Jannini

и другие.

International Journal of Impotence Research, Год журнала: 2024, Номер 36(4), С. 452 - 453

Опубликована: Фев. 24, 2024

Язык: Английский

Процитировано

6
Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020 DOI Creative Commons

Jiemei Liang,

Xiting Chen,

Jinfa Huang

и другие.

BMC Women s Health, Год журнала: 2023, Номер 23(1)

Опубликована: Март 11, 2023

There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed find out if are independently related infertility.From the National Health and Nutrition Examination Survey (NHANES) 2013-2020, a total sample of 5872 chosen participants between ages 18 49 were identified for cross-sectional study. The (mg/dL) each participant tested, reproductive health questionnaire was used evaluate subject's status. Both in analyses full subgroup, logistic regression models relationship two variables. A stratified multivariate model perform subgroup analysis based on levels.Infertility found 649 (11.1%) 5,872 adults study, with greater mean (4.7 mg/dL vs. 4.5 mg/dL). Serum associated infertility both initial adjusted models. According regression, odds be significantly higher rising (Q4 [≥ 5.2 mg/dL] Q1 [≤ 3.6 mg/dL]), ratio [aOR] = 1.59, p 0.002]. data suggests that there dose-response two.The results from nationally representative United States confirmed idea link increased Future research necessary explicate underlying mechanisms relationship.

Язык: Английский

Процитировано

10
Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction DOI
Yafei Liu, Huanhuan Wang,

Yin-Hong Geng

и другие.

Reproductive Sciences, Год журнала: 2024, Номер 31(8), С. 2184 - 2198

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

4