Effect of Skin Melinjo Extract (Gnetum Gnemon) On Expression URAT1 and GLUT9 Genes In Hyperuricemia DOI Open Access

Nurul Amalia Sofyan,

Syafruddin Ilyas, Yetty Machrina

et al.

International Journal of Ecophysiology, Journal Year: 2023, Volume and Issue: 5(1), P. 13 - 18

Published: Feb. 28, 2023

Hyperuricemia is defined as a metabolic syndrome disease with markers characteristic of uric acid production that exceed normal limits. Normal levels range from 3.4-7.0 mg/dl in adult men and 2.4 -6.0 women. So if the limit, it will cause can not be fully metabolized hyperuricemia. About 70% excreted through kidneys. The kidneys are therefore organs have an important role maintaining homeostasis general, complex molecular mechanisms. Reabsorption occurs by URAT1 GLUT9 has human body, where reabsorbed then flowed back into blood so affects body. Preliminary data showed ethanol extract melinjo skin contains 3 main Flavonoid compounds higher Binding affinity value compared to allopurinol, effect overcoming levels.

Language: Английский

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction DOI Open Access
Giovanni Corona, Domenico Cucinotta, Giorgio Di Lorenzo

et al.

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(6), P. 1241 - 1274

Published: Jan. 25, 2023

Language: Английский

Citations

61
Future perspectives for PDE5 inhibitors bridging the gap between cardiovascular health and psychological status DOI Creative Commons
Andrea Sansone, Eugenia Guida, Susanna Dolci

et al.

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 26, 2025

Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking new discipline sexual medicine. Findings from number laboratories and clinics around world unanimously demonstrated following: (i) major cause ED is directly or indirectly related cardiovascular disease (CVD); (ii) CVDs share same risk factors, mainly lifestyle choices; (iii) first therapeutic approach both transform harmful lifestyles into virtuous lifestyles; (iv) PDE5is general, particularly very safe, if not protective, use CVD patients. However, has faced several challenges. Many patients some healthcare providers (HCPs) often misconception these drugs can CVD. Some might desire fulfill unmet need privacy linked stigma being treated be enticed by idea buying online, either because shame cheaper prices, without knowing risks associated with counterfeit drugs. aim this narrative revision current literature demonstrate orodispersible film sildenafil safe CV perspective; it discreet formulation respects privacy; virtually unique PDE5i too expensive produce outside correct channels, making impossible counterfeit.

Language: Английский

Citations

2
Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility DOI Creative Commons

Xiaoqin Xin,

Qi Zhang, Jing Xu

et al.

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 33 - 42

Published: Jan. 1, 2025

Background: Few studies have evaluated the correlation between serum uric acid (SUA) levels and prevalence of female infertility in general population, effect magnesium intake on this has not been investigated. Methods: All participants aged 18– 45 years at baseline were enrolled from National Health Nutritional Examination Surveys (NHANES) 2013– 2018. The continuous variable SUA was divided into quartile (Q1: ≤ 3.7 mg/dL, Q2: 3.7– 4.4 Q3: 4.4– 5.1 Q4: ≥ mg/dL). Multivariable logistic regression used to estimate odds ratios (OR) 95% confidence intervals (CI). Dietary two groups based median number (low intake, < 243 mg/day; high mg/day). Results: A total 3185 included final analysis, 10.58% whom infertile. In full adjustment model, positively associated with (OR=1.13, CI: 1.01– 1.27). Compared lowest (Q1), highest (Q4) had an increased risk by 62% (OR=1.62, 1.1– 2.4). Moreover, we found interactive association adjusted models (interaction likelihood ratio test: P=0.029), implying that may ameliorate infertility. Conclusion: This study is first report dietary relationship Plain Language Summary: Infertility affects approximately 15% reproductive-aged couples worldwide. population. role through its effects We present existed, which implied casts a light how infertility, hinting importance supplementing various ways. Keywords: acid, dietary,

Language: Английский

Citations

1
Erectile dysfunction and premature ejaculation: a continuum movens supporting couple sexual dysfunction DOI Open Access
Giovanni Corona

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(11), P. 2029 - 2041

Published: May 3, 2022

Language: Английский

Citations

29
Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study DOI

D. G. Corona,

Walter Vena, Alessandro Pizzocaro

et al.

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(11), P. 2195 - 2211

Published: July 29, 2023

Language: Английский

Citations

19
The canary in the coal mine. Comment on “Association between cardiometabolic index and erectile dysfunction among US adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 2001–2004” DOI

Dimitri Yannas,

Andrea Sansone, Emmanuele A. Jannini

et al.

International Journal of Impotence Research, Journal Year: 2024, Volume and Issue: 36(4), P. 452 - 453

Published: Feb. 24, 2024

Language: Английский

Citations

5
Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction DOI
Yafei Liu, Huanhuan Wang,

Yin-Hong Geng

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(8), P. 2184 - 2198

Published: Feb. 20, 2024

Language: Английский

Citations

4
Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020 DOI Creative Commons

Jiemei Liang,

Xiting Chen,

Jinfa Huang

et al.

BMC Women s Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 11, 2023

There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed find out if are independently related infertility.From the National Health and Nutrition Examination Survey (NHANES) 2013-2020, a total sample of 5872 chosen participants between ages 18 49 were identified for cross-sectional study. The (mg/dL) each participant tested, reproductive health questionnaire was used evaluate subject's status. Both in analyses full subgroup, logistic regression models relationship two variables. A stratified multivariate model perform subgroup analysis based on levels.Infertility found 649 (11.1%) 5,872 adults study, with greater mean (4.7 mg/dL vs. 4.5 mg/dL). Serum associated infertility both initial adjusted models. According regression, odds be significantly higher rising (Q4 [≥ 5.2 mg/dL] Q1 [≤ 3.6 mg/dL]), ratio [aOR] = 1.59, p 0.002]. data suggests that there dose-response two.The results from nationally representative United States confirmed idea link increased Future research necessary explicate underlying mechanisms relationship.

Language: Английский

Citations

10
Erectile Dysfunction and Oxidative Stress: A Narrative Review DOI Open Access

Dake Zhu,

Quan Minh Pham, Chunlin Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3073 - 3073

Published: March 27, 2025

Erectile dysfunction (ED) is a prevalent condition affecting male sexual health, characterized by the inability to achieve or maintain satisfactory erections. ED has multifactorial pathogenesis in which psychological, hormonal, neurologic, cardiovascular, and lifestyle factors all contribute progressive decline of erectile function. A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production antioxidant defenses, disrupts endothelial function, reduces nitric oxide (NO) bioavailability, contributes vascular dysfunction. This narrative review explores interplay OS ED, focusing on roles ROS sources such as NADPH oxidase, xanthine uncoupled synthase, mitochondrial It examines impact chronic conditions like hypertension, diabetes mellitus, hyperlipidemia, hypogonadism, smoking obesity, exacerbate through systemic effects. Emerging research underscores potential therapies interventions restore redox balance, improve mitigate ED's progression. also highlights gaps understanding molecular pathways linking emphasizing need for further develop targeted therapeutic strategies.

Language: Английский

Citations

0
Infection, inflammation, and sexual function in male and female patients—recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024) DOI Creative Commons
Fernando Nestor Fácio, Elena Colonnello, Laith Alzweri

et al.

Sexual Medicine Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0