Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

Emergent Materials, Год журнала: 2022, Номер 5(6), С. 1593 - 1615

Опубликована: Янв. 4, 2022

Язык: Английский

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Chiral Metal–Organic Frameworks

Chemical Reviews, Год журнала: 2022, Номер 122(9), С. 9078 - 9144

Опубликована: Март 28, 2022

In the past two decades, metal-organic frameworks (MOFs) or porous coordination polymers (PCPs) assembled from metal ions clusters and organic linkers via metal-ligand bonds have captivated significant scientific interest on account of their high crystallinity, exceptional porosity, tunable pore size, modularity, diverse functionality. The opportunity to achieve functional materials by design with promising properties, unattainable for solid-state in general, distinguishes MOFs other classes materials, particular, traditional such as activated carbon, silica, zeolites, thereby leading complementary properties. Scientists conducted intense research production chiral MOF (CMOF) specific applications including but not limited recognition, separation, catalysis since discovery first CMOF (i.e., d- l-POST-1). At present, CMOFs become interdisciplinary between chirality chemistry, material which involve many subjects physics, optics, medicine, pharmacology, biology, crystal engineering, environmental science, etc. this review, we will systematically summarize recent progress regarding strategies, synthetic approaches, cutting-edge applications. highlight successful implementation asymmetric catalysis, enantioselective sensing. We envision that review provide readers a good understanding chemistry and, more importantly, facilitate endeavors rational multifunctional industrial implementation.

Язык: Английский

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Graphene-Based Metal–Organic Framework Hybrids for Applications in Catalysis, Environmental, and Energy Technologies

Chemical Reviews, Год журнала: 2022, Номер 122(24), С. 17241 - 17338

Опубликована: Ноя. 1, 2022

Current energy and environmental challenges demand the development design of multifunctional porous materials with tunable properties for catalysis, water purification, conversion storage. Because their amenability to de novo reticular chemistry, metal-organic frameworks (MOFs) have become key in this area. However, usefulness is often limited by low chemical stability, conductivity inappropriate pore sizes. Conductive two-dimensional (2D) robust structural skeletons and/or functionalized surfaces can form stabilizing interactions MOF components, enabling fabrication nanocomposites characteristics. Graphene its functional derivatives are largest class 2D possess remarkable compositional versatility, diversity, controllable surface chemistry. Here, we critically review current knowledge concerning growth, structure, graphene derivatives, MOFs, graphene@MOF composites as well associated structure-property-performance relationships. Synthetic strategies preparing tuning also comprehensively reviewed together applications gas storage/separation, catalysis (organo-, electro-, photocatalysis), electrochemical storage conversion. hybrids practical addressed, revealing areas future investigation. We hope that will inspire further exploration new energy, electronic, biomedical, photocatalysis studies on previously unreported known reveal potential "diamonds rough".

Язык: Английский

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Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113891 - 113891

Опубликована: Июль 26, 2021

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9) is a potent technology for gene-editing. Owing to its high specificity and efficiency, extensity used human diseases treatment, especially cancer, which involves multiple genetic alterations. Different concepts of cancer treatment by are established. However, significant challenges remain clinical applications. The greatest challenge therapy how safely efficiently deliver it target sites in vivo. Nanotechnology has greatly contributed drug delivery. Here, we present the action mechanisms CRISPR/Cas9, application focus on nanotechnology-based delivery gene editing immunotherapy pave way translation. We detail difficult barriers CRISIR/Cas9 vivo discuss relative solutions encapsulation, delivery, controlled release, cellular internalization, endosomal escape.

Язык: Английский

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Gas sensing performance of 2D nanomaterials/metal oxide nanocomposites: a review

Journal of Materials Chemistry C, Год журнала: 2021, Номер 9(28), С. 8776 - 8808

Опубликована: Янв. 1, 2021

This review aims at providing a comprehensive summary of the current advancements in 2D/metal-oxide based heterostructures as gas sensors.

Язык: Английский

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Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1923 - 1923

Опубликована: Фев. 8, 2022

In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many the demands for physiologically responsive nanomaterials in applications involving human body cannot be met by conventional technologies. Due to field’s importance, considerable effort has been expended, and achieved remarkable success thus far. This review summarizes advancements their biosensing molecular imaging. The change structure or increase chemical reaction ratio response specific bio-relevant stimuli (such pH, redox potentials, enzyme kinds, concentrations) order improve signal diagnosis. We use various case studies illustrate existing issues provide clear sense direction this area. Furthermore, limitations prospects these diagnosis are also discussed.

Язык: Английский

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Synthesis of various dimensional metal organic frameworks (MOFs) and their hybrid composites for emerging applications – A review

Chemosphere, Год журнала: 2022, Номер 298, С. 134184 - 134184

Опубликована: Март 7, 2022

Язык: Английский

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Metal‐Organic Frameworks Nanocomposites with Different Dimensionalities for Energy Conversion and Storage

Advanced Energy Materials, Год журнала: 2021, Номер 12(4)

Опубликована: Апрель 17, 2021

Abstract Metal‐organic frameworks (MOFs) have emerged as a promising material with unique features such diverse composition, high porosity, tunable pore structure, and versatile functionality. These characteristics attracted significant research interest in photochemical electrochemical energy conversion storage (ECS). However, the utilization of pristine MOFs ECS is still hindered by their limited conductivity Recently, integration functional materials has been studied intensively to surmount deficiencies while maintaining original advantages. The act essential active species, or supports accommodate stabilize these materials. incorporation can deliver synergistic effects enhance properties MOFs, thus greatly improving efficiency stability ECS. favorable nanostructures MOF composites different dimensionalities including 0D, 1D, 2D, 3D further enrich structural diversity. Their advanced contribute enhanced robustness, exposure sites, mass/electron transport, which are for practical In this review, recent progress rational design summarized. extensive applications systems also discussed elucidating advantages, challenges, prospects.

Язык: Английский

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Morphology control through the synthesis of metal-organic frameworks

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 314, С. 102864 - 102864

Опубликована: Фев. 26, 2023

Designable morphology and predictable properties are the most challenging goals in material engineering. Features such as shape, size, porosity, agglomeration ratio significantly affect final of metal-organic frameworks (MOFs) can be regulated throughout synthesis parameters but require a deep understanding mechanisms MOFs formation. Herein, we systematically summarize effects individual factors, pH reaction mixture, including acidic or basic character modulators, temperature, solvents types, surfactants type content ionic liquids on growing MOFs. We identified main MOFs' growth leading to different particles next discuss effect miscellaneous based related nucleation, formation structure, coordination modulation, protonation/deprotonation acting modulation by capping agents. The microwaves ultrasound employment during is also considered due their affecting especially nucleation steps

Язык: Английский

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Applications of Metal-Organic Frameworks as Drug Delivery Systems

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4458 - 4458

Опубликована: Апрель 18, 2022

In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of compounds. The DSSs allow release active pharmaceutical ingredient accomplish desired therapeutic response. Over past few decades, there has been exponential growth many classes coordination polymers, MOFs gained popularity over other identified higher biocompatibility versatile loading capabilities. This review presents assesses most recent research, findings, challenges associated with use DDSs. Among commonly used for investigated-purpose MOFs, polymers complexes based on synthetic natural are well known. Specific attention is given stimuli- multistimuli-responsive MOFs-based Of interest in COVID-19 pandemic combination therapy multimodal systems.

Язык: Английский

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