Biomedical Metal–Organic Framework Materials: Perspectives and Challenges DOI Creative Commons
Alec Wang,

Madeline Walden,

Romy Ettlinger

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(43)

Published: Nov. 21, 2023

Abstract Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity retain organic (drug) molecules, metals, gases, effectively channel electrons photons, survive harsh physiological conditions such as low pH, even protect sensitive biomolecules. Extensive preclinical research has been carried out treat several pathologies and, recently, integration other stents implants demonstrated promising performance regenerative medicine. However, there remains a gap between MOF translation into clinically societally relevant medicinal products. Here, intrinsic features of outlined suitability specific applications detoxification, drug gas delivery, or (combination) therapy platforms is discussed. Furthermore, examples how have engineered evaluated different medical indications, including cancer, microbial, inflammatory diseases described. Finally, challenges facing clinic critically examined, goal establishing directions more realistic approaches that can bridge translational MOF‐containing (nano)materials.

Language: Английский

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems DOI Open Access

V. Chandrakala,

Valmiki Aruna, Gangadhara Angajala

et al.

Emergent Materials, Journal Year: 2022, Volume and Issue: 5(6), P. 1593 - 1615

Published: Jan. 4, 2022

Language: Английский

Citations

539
Chiral Metal–Organic Frameworks DOI
Wei Gong, Zhijie Chen, Jinqiao Dong

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(9), P. 9078 - 9144

Published: March 28, 2022

In the past two decades, metal-organic frameworks (MOFs) or porous coordination polymers (PCPs) assembled from metal ions clusters and organic linkers via metal-ligand bonds have captivated significant scientific interest on account of their high crystallinity, exceptional porosity, tunable pore size, modularity, diverse functionality. The opportunity to achieve functional materials by design with promising properties, unattainable for solid-state in general, distinguishes MOFs other classes materials, particular, traditional such as activated carbon, silica, zeolites, thereby leading complementary properties. Scientists conducted intense research production chiral MOF (CMOF) specific applications including but not limited recognition, separation, catalysis since discovery first CMOF (i.e., d- l-POST-1). At present, CMOFs become interdisciplinary between chirality chemistry, material which involve many subjects physics, optics, medicine, pharmacology, biology, crystal engineering, environmental science, etc. this review, we will systematically summarize recent progress regarding strategies, synthetic approaches, cutting-edge applications. highlight successful implementation asymmetric catalysis, enantioselective sensing. We envision that review provide readers a good understanding chemistry and, more importantly, facilitate endeavors rational multifunctional industrial implementation.

Language: Английский

Citations

364
Graphene-Based Metal–Organic Framework Hybrids for Applications in Catalysis, Environmental, and Energy Technologies DOI Creative Commons
Kolleboyina Jayaramulu, Soumya Mukherjee, Dulce M. Morales

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(24), P. 17241 - 17338

Published: Nov. 1, 2022

Current energy and environmental challenges demand the development design of multifunctional porous materials with tunable properties for catalysis, water purification, conversion storage. Because their amenability to de novo reticular chemistry, metal-organic frameworks (MOFs) have become key in this area. However, usefulness is often limited by low chemical stability, conductivity inappropriate pore sizes. Conductive two-dimensional (2D) robust structural skeletons and/or functionalized surfaces can form stabilizing interactions MOF components, enabling fabrication nanocomposites characteristics. Graphene its functional derivatives are largest class 2D possess remarkable compositional versatility, diversity, controllable surface chemistry. Here, we critically review current knowledge concerning growth, structure, graphene derivatives, MOFs, graphene@MOF composites as well associated structure-property-performance relationships. Synthetic strategies preparing tuning also comprehensively reviewed together applications gas storage/separation, catalysis (organo-, electro-, photocatalysis), electrochemical storage conversion. hybrids practical addressed, revealing areas future investigation. We hope that will inspire further exploration new energy, electronic, biomedical, photocatalysis studies on previously unreported known reveal potential "diamonds rough".

Language: Английский

Citations

196
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment DOI Creative Commons
Xiaoyu Xu, Chang Liu, Yonghui Wang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 176, P. 113891 - 113891

Published: July 26, 2021

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9) is a potent technology for gene-editing. Owing to its high specificity and efficiency, extensity used human diseases treatment, especially cancer, which involves multiple genetic alterations. Different concepts of cancer treatment by are established. However, significant challenges remain clinical applications. The greatest challenge therapy how safely efficiently deliver it target sites in vivo. Nanotechnology has greatly contributed drug delivery. Here, we present the action mechanisms CRISPR/Cas9, application focus on nanotechnology-based delivery gene editing immunotherapy pave way translation. We detail difficult barriers CRISIR/Cas9 vivo discuss relative solutions encapsulation, delivery, controlled release, cellular internalization, endosomal escape.

Language: Английский

Citations

187
Gas sensing performance of 2D nanomaterials/metal oxide nanocomposites: a review DOI
Vijendra Singh Bhati, Mahesh Kumar, Rupak Banerjee

et al.

Journal of Materials Chemistry C, Journal Year: 2021, Volume and Issue: 9(28), P. 8776 - 8808

Published: Jan. 1, 2021

This review aims at providing a comprehensive summary of the current advancements in 2D/metal-oxide based heterostructures as gas sensors.

Language: Английский

Citations

182
Synthesis of various dimensional metal organic frameworks (MOFs) and their hybrid composites for emerging applications – A review DOI Creative Commons

J Annamalai,

Preethika Murugan,

Dhanraj Ganapathy

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 298, P. 134184 - 134184

Published: March 7, 2022

Language: Английский

Citations

177
Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application DOI Open Access
Zhenqi Jiang, Han Xiao, Chen Zhao

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1923 - 1923

Published: Feb. 8, 2022

In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many the demands for physiologically responsive nanomaterials in applications involving human body cannot be met by conventional technologies. Due to field’s importance, considerable effort has been expended, and achieved remarkable success thus far. This review summarizes advancements their biosensing molecular imaging. The change structure or increase chemical reaction ratio response specific bio-relevant stimuli (such pH, redox potentials, enzyme kinds, concentrations) order improve signal diagnosis. We use various case studies illustrate existing issues provide clear sense direction this area. Furthermore, limitations prospects these diagnosis are also discussed.

Language: Английский

Citations

176
Metal‐Organic Frameworks Nanocomposites with Different Dimensionalities for Energy Conversion and Storage DOI
Yang Bai,

Chunli Liu,

Yuying Shan

et al.

Advanced Energy Materials, Journal Year: 2021, Volume and Issue: 12(4)

Published: April 17, 2021

Abstract Metal‐organic frameworks (MOFs) have emerged as a promising material with unique features such diverse composition, high porosity, tunable pore structure, and versatile functionality. These characteristics attracted significant research interest in photochemical electrochemical energy conversion storage (ECS). However, the utilization of pristine MOFs ECS is still hindered by their limited conductivity Recently, integration functional materials has been studied intensively to surmount deficiencies while maintaining original advantages. The act essential active species, or supports accommodate stabilize these materials. incorporation can deliver synergistic effects enhance properties MOFs, thus greatly improving efficiency stability ECS. favorable nanostructures MOF composites different dimensionalities including 0D, 1D, 2D, 3D further enrich structural diversity. Their advanced contribute enhanced robustness, exposure sites, mass/electron transport, which are for practical In this review, recent progress rational design summarized. extensive applications systems also discussed elucidating advantages, challenges, prospects.

Language: Английский

Citations

151
Applications of Metal-Organic Frameworks as Drug Delivery Systems DOI Open Access
Bianca Maranescu, Aurelia Visa

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4458 - 4458

Published: April 18, 2022

In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of compounds. The DSSs allow release active pharmaceutical ingredient accomplish desired therapeutic response. Over past few decades, there has been exponential growth many classes coordination polymers, MOFs gained popularity over other identified higher biocompatibility versatile loading capabilities. This review presents assesses most recent research, findings, challenges associated with use DDSs. Among commonly used for investigated-purpose MOFs, polymers complexes based on synthetic natural are well known. Specific attention is given stimuli- multistimuli-responsive MOFs-based Of interest in COVID-19 pandemic combination therapy multimodal systems.

Language: Английский

Citations

147
Morphology control through the synthesis of metal-organic frameworks DOI Creative Commons
Justyna Łuczak, Malwina Kroczewska, Mateusz A. Baluk

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 314, P. 102864 - 102864

Published: Feb. 26, 2023

Designable morphology and predictable properties are the most challenging goals in material engineering. Features such as shape, size, porosity, agglomeration ratio significantly affect final of metal-organic frameworks (MOFs) can be regulated throughout synthesis parameters but require a deep understanding mechanisms MOFs formation. Herein, we systematically summarize effects individual factors, pH reaction mixture, including acidic or basic character modulators, temperature, solvents types, surfactants type content ionic liquids on growing MOFs. We identified main MOFs' growth leading to different particles next discuss effect miscellaneous based related nucleation, formation structure, coordination modulation, protonation/deprotonation acting modulation by capping agents. The microwaves ultrasound employment during is also considered due their affecting especially nucleation steps

Language: Английский

Citations

146