Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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The role of lipid metabolic reprogramming in tumor microenvironment

Theranostics, Год журнала: 2023, Номер 13(6), С. 1774 - 1808

Опубликована: Янв. 1, 2023

Metabolic reprogramming is one of the most important hallmarks malignant tumors.Specifically, lipid metabolic has marked impacts on cancer progression and therapeutic response by remodeling tumor microenvironment (TME).In past few decades, immunotherapy revolutionized treatment landscape for advanced cancers.Lipid plays pivotal role in regulating immune to immunotherapy.Here, we systematically reviewed characteristics, mechanism, cells TME, appraised effects various cell death modes (specifically ferroptosis) metabolism, summarized antitumor therapies targeting metabolism.Overall, profound microenvironment; therefore, may lead development innovative clinical applications including sensitizing immunotherapy.

Язык: Английский

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Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 23, 2023

The exogenous excitation requirement and electron-hole recombination are the key elements limiting application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, heat. resulting temperature difference on BST NSs initiates effect, driving reactive oxygen species production. H2O2 not only serves as substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing efflux. This further exacerbates calcium overload-mediated therapy. Additionally, promotes DC maturation antigen presentation, facilitating immunotherapy. It worth noting that NP hydrolyzes very slowly in normal cells, O2 without causing any adverse effects. Tumor-specific combined therapy, ion interference immunotherapy exhibit excellent antitumor performance female mice.

Язык: Английский

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A Hierarchical Structured Fiber Device Remodeling the Acidic Tumor Microenvironment for Enhanced Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(21)

Опубликована: Март 13, 2023

Abstract The acidic microenvironment of tumors significantly reduces the anti‐tumor effect immunotherapy. Herein, a hierarchically structured fiber device is developed as local drug delivery system for remodeling tumor (TME) to improve therapeutic Proton pump inhibitors in matrix can be sustainedly released inhibit efflux intracellular H + from cells, resulting TME. targeted micelles and M1 macrophage membrane‐coated nanoparticles internal cavities induce immunogenic cell death (ICD) cells phenotypic transformation tumor‐associated macrophages (TAMs), respectively. relief acidity TME further promotes ICD polarization TAMs, alleviating immunosuppressive synergistically enhancing antitumor immune response. In vivo results reveal this restores pH value 6.8 7.2 exhibit an excellent immunotherapeutic effect.

Язык: Английский

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A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(19)

Опубликована: Янв. 18, 2024

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn constructed for achieving simultaneous interference OXPHOS glycolysis. The core–shell ZSZC nanoparticles can break down microenvironment. This leads sustained release calcium overload disrupt normal functioning mitochondria by inhibiting expression cytochrome c causing damage mitochondrial membrane potential. Meanwhile, presence 2+ hinders typical process impeding lactate dehydrogenase glyceraldehyde‐3‐phosphate dehydrogenase. synchronous hampers supply cells. Additionally, expedite necrosis vivo inducing cellular acidification calcification. Therefore, this energy‐blocking strategy will completely deplete reserves provide new insights exploring bioenergetic inhibition treatment approach.

Язык: Английский

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Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca²⁺/Cu²⁺ Dual-Ions Nano Trap for Breast Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(9), С. 6975 - 6989

Опубликована: Фев. 20, 2024

Regarded as one of the hallmarks tumorigenesis and tumor progression, evasion apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid apoptosis by synchronously inducing paraptosis together with was successfully designed fabricated breast treatment. brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were via gas diffusion method. Further on, Cu2+-tannic acid metal phenolic network embedded onto NPs surface self-assembling, followed mDSPE-PEG/lipid capping form DSF-loaded dual-ions trap". The as-prepared nanotrap undergo acid-triggered biodegradation upon being endocytosed cells within lysosome Ca2+, Cu2+, DSF releasing simultaneously. released Ca2+ could cause mitochondrial overload lead hydrogen peroxide (H2O2) overexpression. Meanwhile, Ca2+/reactive oxygen species-associated dysfunction death. Most importantly, be further induced strengthened toxic dithiocarbamate (DTC)–copper complexes formed Cu2+ combined DTC, metabolic products DSF. Additionally, will reduced intracellular glutathione generate Cu+, which can catalyze H2O2 produce hydroxyl radical Cu+-mediated Fenton-like reaction apoptosis. Both in vitro cellular assays vivo antitumor evaluations confirmed therapeutic efficiency dual ion nano trap. This study broaden cognition scope dual-ion-mediated multifunctional nanoplatform.

Язык: Английский

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2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca²⁺ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Язык: Английский

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Photo‐Controlled Calcium Overload from Endogenous Sources for Tumor Therapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 9, 2024

Designing reactive calcium-based nanogenerators to produce excess calcium ions (Ca

Язык: Английский

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Employing Piezoelectric Mg²⁺‐Doped Hydroxyapatite to Target Death Receptor‐Mediated Necroptosis: A Strategy for Amplifying Immune Activation

Advanced Science, Год журнала: 2024, Номер 11(13)

Опубликована: Янв. 22, 2024

Abstract Although immunogenic cell death (ICD) inducers evidently enhance the effectiveness of immunotherapy, their potential is increasingly restricted by development apoptosis resistance in tumor cells, poor immunogenicity, and low T‐cell immune responsiveness. In this study, for first time, piezoelectrically catalyzed Mg 2+ ‐doped hydroxyapatite (Mg‐HAP) nanoparticles, which are coated with a mesoporous silica layer loaded ONC201 as an agonist to specifically target receptor DR5 on ultimately developing Mg‐HAP@MS/ONC201 nanoparticle (MHMO NP) system, engineered. Owing its excellent piezoelectric properties, MHMO facilitates release significant amount reactive oxygen species Ca within effectively promoting upregulation expression inducing necroptosis overcome resistance. Concurrently, released microenvironment promotes CD8 + T activation response antitumor reaction induced ICD. Using RNA‐seq analysis, it elucidated that can activate NF‐κB pathway under catalysis, thus M1‐type macrophage polarization. summary, dual‐targeting therapy system targets both cells catalysis designed. This holds substantial advancements immunotherapy.

Язык: Английский

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Advancements in Metal and Metal Oxide Nanoparticles for Targeted Cancer Therapy and Imaging: Mechanisms, Applications, and Safety Concerns

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106622 - 106622

Опубликована: Янв. 1, 2025

Язык: Английский

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