Biosensors and Bioelectronics X, Год журнала: 2024, Номер unknown, С. 100548 - 100548
Опубликована: Сен. 1, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(37)
Опубликована: Апрель 25, 2024
Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer indocyanine green (ICG) O 2 ‐saturated perfluorohexane (PFH), denoted as ‐PFH@CHPI nanoparticles, to induce ferroptosis. In response specific TME, CHP can synergistically catalyze Fenton reactions consume endogenous glutathione, leading accumulation of reactive oxygen species. Upon near‐infrared irradiation, ‐PFH@CHPI‐enabled photothermal effect simultaneously accelerate catalytic trigger release photodynamic therapy promote oxidative stress. Notably, be effectively activated through Cu + ‐mediated dihydrolipoamide S‐acetyltransferase aggregation Fe–S cluster protein loss. Concurrently, tilt redox balance is favorable lipid peroxidation glutathione peroxidase 4 inactivation, resulting an augmented effect. Mechanistically, stress‐boosted jointly disrupt mitochondrial metabolism, which turn exacerbates stress, thus realizing a mutually enhanced This work may provide new guidance utilizing copper/ferrous‐engineering cuproptosis/ferroptosis synergetic therapy.
Язык: Английский
Процитировано
31
Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151628 - 151628
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
26
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future
Язык: Английский
Процитировано
3
Talanta, Год журнала: 2024, Номер 274, С. 126003 - 126003
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
13
Talanta, Год журнала: 2024, Номер 279, С. 126544 - 126544
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
13
Nanoscale, Год журнала: 2024, Номер 16(16), С. 7786 - 7824
Опубликована: Янв. 1, 2024
The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Abstract Catalytic medicine, using enzymes or nanozymes, is an emerging method for cancer treatment. However, its applicability limited by the low catalytic activity in tumor microenvironment (TME). In this work, a versatile and synthesis‐friendly nanozyme, CeO 2 Mn 1.08 O x nanoclusters, prepared. This novel Ce─Mn heterojunction formed oxidation of nanoparticles through H SO 4 /KMnO . exhibits high multi‐enzymatic activities acts as catalase (CAT), peroxidase (POD), oxidase (OXD) mimics under acidic conditions. It can regulate TME relieving hypoxia consuming endogenous glutathione (GSH). Glucose (GOx) then incorporated into linked with poly(ethylene glycol) (PEG) to obtain cascade enzyme system (Ce─Mn)‐PEI/GOx‐PEG. CAT‐like properties, which sensitize GOx‐based starvation therapy, POD‐ OXD‐like generate highly cytotoxic reactive oxygen species (ROS) cells. The glucose catabolic product, , also used ROS. addition, structure provides near‐infrared (NIR) photothermal capability, making it suitable therapy (PTT). Density functional theory (DFT) calculations provide possible reasons capability When combining mild PTT (Ce─Mn)‐PEI/GOx‐PEG efficiently ablate tumors.
Язык: Английский
Процитировано
10
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159464 - 159464
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Abstract Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects regeneration efficiency and wellness of patients. Piezoelectric materials exhibit outstanding advantage producing electrons without external power supply. The ability electron enrichment reactive oxygen species generation through noninvasive stimulations enables piezoelectric potential applications antibacterial. Many studies have proved feasibility as a functional addition antibacterial biomaterial. In fact, numerous with ingenious designs are reported to be effective processes. This review summarizes mechanisms piezoelectric, illuminating their combating bacteria. Recent advancement design construction biomaterial including defect engineering, heterojunction, synergy metal composite scaffold configuration thoroughly reviewed. Moreover, therapeutic effects common tissues requirements introduced, such orthopedics, dental, wound healing. Finally, development prospects points deserving further exploration listed. is expected provide valuable insight into relationship between processes materials, inspiring constructive this emerging scientific discipline.
Язык: Английский
Процитировано
2
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Язык: Английский
Процитировано
2