International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138576 - 138576
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(13), С. 3171 - 3190
Опубликована: Янв. 1, 2024
This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.
Язык: Английский
Процитировано
35
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Abstract High‐tension site wounds are frequently accompanied by challenges associated with hypertrophic scarring. The key to achieving scar‐free healing is the creation of a mechanical environment conducive skin regeneration. Herein, simple rolling punctures utilized on angle transform molds develop cat tongue prick bionic angle‐adjustable microneedles (TPMNs) maintain firm grip periwound skin, thereby reducing tissue tension. integration TPMNs triboelectric nanogenerators (TENGs) enables excellent conductive and properties. system can provide stable spatial electric field around wound promote cell migration. As microfluid reaches TPMNs, self‐driving force enhanced unique design control flow rate. Sufficient evidence has shown that expedite contraction regeneration while concurrently scar formation in mouse trauma model experiments. innovative TPMNs‐TENGs synergistically provides highly functional platform for tension relief, which suitable treatment this study potentially extends construction regulation smart wearable devices.
Язык: Английский
Процитировано
2
Nano-Micro Letters, Год журнала: 2024, Номер 17(1)
Опубликована: Окт. 4, 2024
Abstract The current single-atom catalysts (SACs) for medicine still suffer from the limited active site density. Here, we develop a synthetic method capable of increasing both metal loading and mass-specific activity SACs by exchanging zinc with iron. constructed iron (h 3 -FNC) high 6.27 wt% an optimized adjacent Fe distance ~ 4 Å exhibit excellent oxidase-like catalytic performance without significant decay after being stored six months promising antibacterial effects. Attractively, “density effect” has been found at high-enough doping amount, which individual sites become close enough to interact each other alter electronic structure, resulting in significantly boosted intrinsic single-atomic h -FNCs 2.3 times compared low- medium-loading SACs. Consequently, overall -FNC is highly improved, mass that are, respectively, 66 315 higher than those commercial Pt/C. In addition, demonstrate efficiently enhanced capability catalyzing oxygen reduction into superoxide anion (O 2 · − ) glutathione (GSH) depletion. Both vitro vivo assays superior efficacy promoting wound healing. This work presents intriguing activity-enhancement effect exhibits impressive therapeutic combating bacterial infections.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
8
Advances in Colloid and Interface Science, Год журнала: 2025, Номер 338, С. 103404 - 103404
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
1
Biomaterials Advances, Год журнала: 2024, Номер 161, С. 213869 - 213869
Опубликована: Апрель 22, 2024
Considering the global burden related to tissue and organ injuries or failures, self-healing hydrogels may be an attractive therapeutic alternative for future. Self-healing are highly hydrated 3D structures with ability self-heal after breaking, this property is attributable a variety of dynamic non-covalent covalent bonds that able re-linking within matrix. specially benefits minimal invasive medical treatments cell-delivery support. Moreover, those tissue-engineered network have demonstrated effectiveness myriad purposes; instance, they could act as delivery-platforms different cargos (drugs, growth factors, cells, among others) in tissues such bone, cartilage, nerve skin. Besides, currently found their way into new novel applications; example, development adhesive hydrogels, by merely aiding surgical closing processes providing biomaterial-tissue adhesion. Furthermore, conductive permit stimuli monitoring natural electrical signals, which facilitated better fitting native diagnosis various health diseases. Lastly, part cyborganics – merge between biology machinery can pave finer healthcare devices diagnostics precision therapies.
Язык: Английский
Процитировано
7
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(27), С. 34641 - 34655
Опубликована: Июнь 27, 2024
Skin injuries and wounds present significant clinical challenges, necessitating the development of advanced wound dressings for efficient healing tissue regeneration. In this context, advancement hydrogels capable counteracting adverse effects arising from undesirable reactive oxygen species (ROS) is importance. This study introduces a hybrid hydrogel with rapid photocuring excellent conformability, tailored to ameliorate hostile microenvironment damaged skin tissues. The hydrogel, composed photoresponsive Gelatin Methacryloyl (GelMA) Molybdenum-based nanoclusters (MNC), exhibits physicochemical characteristics conductive vitro studies demonstrated cytocompatibility ROS-responsive behavior MNC/GelMA hydrogels, confirming their ability promote human dermal fibroblasts (HDF) functions. incorporation MNC into GelMA not only enhances HDF adhesion, proliferation, migration but also shields against oxidative damage induced by hydrogen peroxide (H2O2). Notably, in vivo evaluation murine full-thickness defects revealed that application led reduced inflammation, accelerated closure, enhanced collagen deposition comparison control groups. Significantly, introduced convenient approach develop situ ROS-scavenging accelerate process without need exogenous cytokines or medications. We consider nanoengineering proposed herein offers potential possibilities therapeutic addressing various skin-related conditions.
Язык: Английский
Процитировано
7
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13622 - 13639
Опубликована: Март 11, 2024
The design of implantable biomaterials involves precise tuning surface features because the early cellular fate on such engineered surfaces is highly influenced by many physicochemical factors [roughness, hydrophilicity, reactive oxygen species (ROS) responsiveness, etc.]. Herein, to enhance soft tissue integration for successful implantation, Ti substrates decorated with uniform layers nanoceria (Ce), called Ti@Ce, were optimally developed a simple and cost-effective in situ immersion coating technique. characterization Ti@Ce shows Ce distribution enhanced roughness (∼3-fold increase) hydrophilicity (∼4-fold adopted ROS-scavenging capacity coating. When human gingival fibroblasts seeded under oxidative stress conditions, supported adhesion, spreading, survivability its capacity. Mechanistically, unique nanocoating resulted higher expression amphiphysin (a nanotopology sensor), paxillin focal adhesion protein), cell adhesive proteins (collagen-1 fibronectin). also led global chromatin condensation decreasing histone 3 acetylation as an differentiation feature. Transcriptome analysis RNA sequencing confirmed remodeling, antiapoptosis, antioxidant, TGF-β signaling-related gene signatures Ti@Ce. As key fibroblast transcription (co)factors, promotes serum response factor MRTF-α nucleus localization. Considering all this, it proposed that engineering approach using could improve biological properties implants, supporting their functioning at interfaces utilization bioactive implant clinical conditions peri-implantitis.
Язык: Английский
Процитировано
6
European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 12, С. 100184 - 100184
Опубликована: Июнь 26, 2024
Polyphenol is a versatile green phytochemical vital in several biomedical applications with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The emergence of novel nanotechnology techniques, such as electrospinning, has proven to be an excellent option for nanotechnology, ensuring effective drug delivery system recognised medicinal plant extracts containing polyphenols electrospun nanofibers can provide the necessary environment encapsulation. Together, have shown promising usage wound healing. When are incorporated into nanofibrous scaffolds, their combined properties enhance cell attachment, proliferation, differentiation. This review explores potential polyphenol-loaded therapy, highlighting importance efficient systems polyphenols. It provides brief assessment specific (resveratrol, curcumin, thymol, quercetin, tannic acid, ferulic hesperidin, gallic kaempferol, chlorogenic acid) that been successfully encapsulated applied treatment. Despite ongoing research, certain carvacrol, oleuropein, kaempferol remain less explored. underscores need continued investigation these while recognising growing application healing more extensive therapeutic use.
Язык: Английский
Процитировано
6
Biomaterials Advances, Год журнала: 2024, Номер 166, С. 214064 - 214064
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
5