Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 2, 2025

As a complex and dynamically regulated process, wound healing is collaboratively carried out by multiple types of cells. However, the precise mechanisms which these cells contribute to immune regulation are not yet fully understood. Although research on bone regeneration has been quite extensive, application bioactive glass (BG) in skin tissue repair remains still relatively underexplored. The review focuses principles latest progress using BGs for repair, highlighting BGs’ special performance requirements, including biological activity, biocompatibility, biodegradability, antibacterial properties, emphasizing their potential repair. In addition, play substantial role regulating various inflammatory (neutrophils, macrophages, mast cells, etc.) [fibroblasts, vascular endothelial mesenchymal stem (MSCs), etc.] involved healing. also covers recent developments composite materials incorporating BGs, demonstrating ability promote angiogenesis, inhibit biofilms, improve responses chronic wounds. Furthermore, have shown effectiveness promoting epithelial collagen deposition burn wounds as well applications scar management post-tumor resection care. Finally, we summarize our views challenges directions emerging field future.

Язык: Английский

---

Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy

Cancers, Год журнала: 2025, Номер 17(5), С. 723 - 723

Опубликована: Фев. 20, 2025

Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.

Язык: Английский

---

MiR-186-5p carried by M2 macrophage-derived exosomes downregulates TRPP2 expression in airway smooth muscle to alleviate asthma progression

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114107 - 114107

Опубликована: Янв. 29, 2025

Bronchial asthma (asthma) is a chronic inflammatory disease of the airways that remains an unresolved problem. Reportedly M2 macrophages and exosomes play role in inflammation, including asthma. We investigated roles macrophage-derived (M2-Exos) effect asthmatic progression by using ovalbumin (OVA) induced mice model. M2-Exos significantly ameliorated pulmonary response airway hyperresponsiveness suppressed aberrant proliferation transient receptor potential polycystic protein 2(TRPP2) expression LPS-stimulated primary smooth muscle cells (ASMCs). Then, we found miR-186-5p could target TRPP2 through online database analysis. However, downregulation inhibitors decreased protective mouse cellular models. was identified selectively combined with polycystin-2 gene encoding protein, inhibited production, downregulated expression. A reduction number calcium (Ca) channels formed on cell membrane leads to intracellular Ca2+ concentration ([Ca2+] i), causing reduced ASMC contraction proliferation, thereby improving remodeling Collectively, conclude exosomal alleviate though downregulating These results may offer novel insight treatment drug delivery

Язык: Английский

---

Immunomodulatory Bioadhesive Technologies

Biomaterials, Год журнала: 2025, Номер unknown, С. 123274 - 123274

Опубликована: Март 1, 2025

Bioadhesives have found significant use in medicine and engineering, particularly for wound care, tissue surgical applications. Compared to traditional closure methods such as sutures staples, bioadhesives offer advantages, including reduced damage, enhanced healing, ease of implementation. Recent progress highlights the synergy immunoengineering strategies, leading immunomodulatory capable modulating immune responses at local sites where are applied. They foster favorable therapeutic outcomes inflammation wounds implants or improve cancer therapy efficacy. The dual functionalities bioadhesion immunomodulation benefit management, regeneration, implantable medical devices, post-surgical management. This review delves into interplay between immunomodulation, highlighting mechanobiological coupling involved. Key areas focus include modulation through chemical physical well application these healing treatment. Discussed remaining challenges achieving long-term stability effectiveness, necessitating further research fully harness clinical potential bioadhesives.

Язык: Английский

---

Multifunctional nanozyme-hydrogel system in bacterial-infected wounds

Опубликована: Апрель 1, 2025

Язык: Английский

---

Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Acute kidney injury (AKI) is a life-threatening condition characterized by rapid decline in the renal function, primarily caused oxidative stress, inflammation, and ferroptosis. Herein, we present selenium-doped carbon dots (Zt-SeCDs) that integrate antioxidant activity with controlled release of Zileuton, 5-lipoxygenase (ALOX5) inhibitor, under high reactive oxygen species (ROS) conditions. This nanoplatform can efficiently deliver leveraging its inherent properties to achieve targeted prevention treatment AKI. In vitro studies have confirmed Zt-SeCDs eliminate excessive ROS, prevent ferroptotic cell death, modulate inflammatory responses reducing expression key pro-inflammatory cytokines. Additionally, regulate ferroptosis through suppression ALOX5 upregulation glutathione peroxidase 4 (GPX4) expression. The significantly improves promotes regeneration damaged tissue, alleviates processes, death. Moreover, monitoring serum indicators observing pathological changes further potential preventing Notably, activate AMPK/FoxO1 signaling pathway, enhancing endogenous defenses protect tissue from damage. promising not only holds significant promise for AKI, but also aims facilitate clinical application.

Язык: Английский

---

Macrophage and Preeclampsia: Macrophage Polarization Imbalance at the Maternal‐Fetal Interface

Journal of Clinical Laboratory Analysis, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

ABSTRACT Background Preeclampsia (PE), as a pathological pregnancy process, is still unclear in its precise pathophysiology. The current consensus on PE pathogenesis that it an immune‐inflammatory response due to placental dysfunction leading multiorgan involvement the mother. Macrophages can polarize into different phenotypes under influence of distinct microenvironments, secreting various cytokines or chemokines with functions. These play roles either promoting inflammation facilitating tissue repair. Studies have observed increase M1 polarization decidual macrophages during occurrence PE, this imbalance contributing immuno‐inflammatory involved formation. Therefore, understanding characteristics provides valuable direction for research related prevention and treatment PE. Methods Authors searched literature PubMed using professional terms “preeclampsia” “macrophage polarization”. obtained was categorized according research. Similar articles are summarized same sections, which divided small sections their specific contents. Results Different studies explored metabolic characteristics, surface markers, secretions, signaling pathways, functions macrophage types, highlighting critical role excessive inflammatory responses development Intervening at maternal‐fetal interface holds significant value Conclusion Understanding combined facilitate targeted

Язык: Английский

---

Supramolecular self-assembling IGF-1 nanofibers modulate neutrophil extracellular traps to accelerate diabetic wound healing

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164259 - 164259

Опубликована: Май 1, 2025

Язык: Английский

---

Bimetallic Peroxide-Based Nanotherapeutics for Immunometabolic Intervention and Induction of Immunogenic Cell Death to Augment Cancer Immunotherapy

Biomaterials, Год журнала: 2024, Номер 315, С. 122934 - 122934

Опубликована: Окт. 30, 2024

Язык: Английский

---

Reactive oxygen species-scavenging biomaterials for neural regenerative medicine

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Development of ROS-scavenging biomaterials for neural regenerative medicine.

Язык: Английский

---