ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(12), С. 5426 - 5441
Опубликована: Ноя. 13, 2023
In
this
study,
we
synthesized
hollow
porous
iron
oxide
nanoparticles
(HPIONPs)
with
surface
modifications
using
polymers,
specifically
chitosan
(Chi),
polyethylene
glycol
(PEG),
and
alginate
(Alg),
to
improve
colloidal
stability
biocompatibility.
For
stability,
Alg-coated
HPIONPs
maintained
size
up
24
h,
only
an
18%
increase,
while
Chi,
PEG,
uncoated
showed
larger
increases
ranging
from
64
140%.
The
biocompatibility
of
polymer-coated
was
evaluated
by
assessing
their
cell
viability,
genotoxicity,
hemocompatibility.
Across
tested
concentrations
6.25
100
μg/mL,
both
minimal
cytotoxicity
against
three
normal
lines:
RAW264.7,
3T3-L1,
MCF10A,
viability
exceeding
80%
at
the
highest
concentration.
Notably,
exhibited
nongenotoxicity
based
on
micronucleus
assay
hemocompatibility,
2–3%
hemolysis
in
mouse
blood,
contrast
which
4–5%.
Furthermore,
MDA-MB-231
breast
cancer
cells
after
a
2
h
exposure
stationary
magnetic
field,
results
death
38
29%
when
treated
respectively.
This
phenomenon
is
attributed
catalyzing
Fenton
Haber-Weiss
reactions,
leading
reactive
oxygen
species
(ROS)-dependent
(r
≥
0.98).
conclusion,
hydrothermal
synthesis
subsequent
modification
polymers
improved
nongenotoxicity,
hemocompatibility
compared
maintaining
closely
similar
levels
cells.
research
has
paved
way
for
further
exploration
polymer
coatings
enhance
overall
performance
safety
profile
delivering
anticancer
drugs.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Апрель 10, 2024
Drug
delivery
via
hydrogel
is
one
of
the
most
effective
methods.
Hydrogels
have
been
described
as
polymeric
water-swollen
materials
and
retain
water
in
distinctive
three-dimensional
complex.
These
are
classified
pH
sensitive
hydrogels,
temperature
homo-polymer
co-polymer
hydrogels
Interpenetrating
Network
(IP-N)
hydrogel.
can
be
prepared
various
techniques,
including
physical
crosslinking,
chemical
free
radical
polymerization,
photo-initiator's
hydrogen
bonding.
Various
polymers
manufacturing
includes
pectin,
chitosan,
cyclodextrin
carrageenan,
etc.
This
review
aims
to
describes
for
drug
delivery,
classifications,
preparation
highlights
novel
applications
medicine.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(12), С. 5426 - 5441
Опубликована: Ноя. 13, 2023
In
this
study,
we
synthesized
hollow
porous
iron
oxide
nanoparticles
(HPIONPs)
with
surface
modifications
using
polymers,
specifically
chitosan
(Chi),
polyethylene
glycol
(PEG),
and
alginate
(Alg),
to
improve
colloidal
stability
biocompatibility.
For
stability,
Alg-coated
HPIONPs
maintained
size
up
24
h,
only
an
18%
increase,
while
Chi,
PEG,
uncoated
showed
larger
increases
ranging
from
64
140%.
The
biocompatibility
of
polymer-coated
was
evaluated
by
assessing
their
cell
viability,
genotoxicity,
hemocompatibility.
Across
tested
concentrations
6.25
100
μg/mL,
both
minimal
cytotoxicity
against
three
normal
lines:
RAW264.7,
3T3-L1,
MCF10A,
viability
exceeding
80%
at
the
highest
concentration.
Notably,
exhibited
nongenotoxicity
based
on
micronucleus
assay
hemocompatibility,
2–3%
hemolysis
in
mouse
blood,
contrast
which
4–5%.
Furthermore,
MDA-MB-231
breast
cancer
cells
after
a
2
h
exposure
stationary
magnetic
field,
results
death
38
29%
when
treated
respectively.
This
phenomenon
is
attributed
catalyzing
Fenton
Haber-Weiss
reactions,
leading
reactive
oxygen
species
(ROS)-dependent
(r
≥
0.98).
conclusion,
hydrothermal
synthesis
subsequent
modification
polymers
improved
nongenotoxicity,
hemocompatibility
compared
maintaining
closely
similar
levels
cells.
research
has
paved
way
for
further
exploration
polymer
coatings
enhance
overall
performance
safety
profile
delivering
anticancer
drugs.
