Development of a labeled-free and labeled electrochemical aptasensor for the detection of cancer antigen 125 by using magnetic g-C3N4/MoS2 nanocomposite

Sensors and Actuators Reports, Год журнала: 2024, Номер 7, С. 100195 - 100195

Опубликована: Апрель 24, 2024

Efficient and timely detection of cancer biomarkers is pivotal for enhancing treatment outcomes mitigating patient mortality. This study addresses the pressing need a swift, accurate, non-invasive method to identify antigen 125 (CA125), vital biomarker in ovarian cancer. Leveraging growing prominence nano-biosensors their high selectivity sensitivity, we present development characterization an innovative electrochemical nano-biosensor. The sensor, featuring aptamer strands immobilized on glassy carbon electrode modified with graphitic nitrides, molybdenum disulfide, magnetic nanoparticles (g-C3N4/MoS2/Fe3O4), demonstrates superior sensitivity accuracy CA125 detection. Utilizing methylene blue labeled ferrocyanide label-free detection, our aptasensor achieves low limit (LOD) at 0.202 U.mL−1 0.215 U.mL−1, respectively, broad range from 2 10 U.mL−1. exhibits pronounced affinity CA125, demonstrating enhanced stability compared other biomolecules. Crucially, evaluation both normal serum samples underscores aptasensor's remarkable performance. These findings not only establish robust foundation future research diagnosis but also highlight potential clinical impact nano-biosensor advancing early methodologies.

Язык: Английский

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Cyclodextrin-based nanocarriers as promising scaffolds for overcoming challenges of doxorubicin delivery in cancer chemotherapy

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100677 - 100677

Опубликована: Янв. 1, 2025

Язык: Английский

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Cyclodextrin nanocarriers in Coordination Chemistry: Enhancing encapsulation and targeted delivery of 5-Fluorouracil for cancer treatment

Results in Chemistry, Год журнала: 2024, Номер 12, С. 101878 - 101878

Опубликована: Окт. 30, 2024

Язык: Английский

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Innovative strategies for organophosphorus remediation: Integrating enzymatic decomposition with membrane technologies

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102298 - 102298

Опубликована: Апрель 1, 2025

Язык: Английский

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Chelating agent-assisted extraction of toxic elements towards ensuring food and beverage safety: Advances and challenges

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 183, С. 118104 - 118104

Опубликована: Дек. 12, 2024

Язык: Английский

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