International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
Critical Reviews in Analytical Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Сен. 17, 2024
This
comprehensive
review
delves
into
the
advancements
and
challenges
in
biosensing,
with
a
strong
emphasis
on
transformative
potential
of
CRISPR
technology
for
early
rapid
detection
infectious
diseases.
It
underscores
versatility
CRISPR/Cas
systems,
highlighting
their
ability
to
detect
both
nucleic
acids
non-nucleic
acid
targets,
seamless
integration
isothermal
amplification
techniques.
The
provides
thorough
examination
latest
developments
CRISPR-based
biosensors,
detailing
unique
properties
such
as
high
specificity
programmability,
which
make
them
particularly
effective
detecting
disease-associated
acids.
While
focuses
due
its
critical
role
diagnosing
diseases,
it
also
explores
broader
applications
thereby
acknowledging
technology's
potential.
Additionally,
identifies
existing
challenges,
need
improved
signal
real-world
applicability,
offers
future
perspectives
aimed
at
overcoming
these
hurdles.
ultimate
goal
is
advance
development
highly
sensitive
specific
biosensors
that
can
be
used
widely
improving
human
health,
point-of-care
settings
resource-limited
environments.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 3, 2025
Multiple
sclerosis
(MS),
a
chronic
autoimmune
disorder
of
the
central
nervous
system
(CNS),
is
characterized
by
inflammation,
demyelination,
and
neurodegeneration,
leading
to
diverse
clinical
manifestations
such
as
fatigue,
sensory
impairment,
cognitive
dysfunction.
Current
pharmacological
treatments
primarily
target
immune
modulation
but
fail
arrest
disease
progression
or
entirely
reverse
CNS
damage.
Mesenchymal
stem
cell
(MSC)
therapy
offers
promising
alternative,
leveraging
its
immunomodulatory,
neuroprotective,
regenerative
capabilities.
This
review
provides
an
in-depth
analysis
MSC
mechanisms
action,
including
regulation,
promotion
remyelination,
neuroregeneration.
It
examines
preclinical
studies
trials
evaluating
efficacy,
safety,
limitations
in
various
MS
phenotypes.
Special
attention
given
challenges
delivery
routes,
dosing
regimens,
integrating
MSCs
with
conventional
therapies.
By
highlighting
advancements
ongoing
challenges,
this
underscores
potential
revolutionize
treatment,
paving
way
for
personalized
combinatory
therapeutic
approaches.
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 5, 2025
Traumatic
brain
injury
(TBI)
is
a
complex
condition
involving
mechanisms
that
lead
to
dysfunction
and
nerve
damage,
resulting
in
significant
morbidity
mortality
globally.
Affecting
~50
million
people
annually,
TBI's
impact
includes
high
death
rate,
exceeding
of
heart
disease
cancer.
Complications
arising
from
TBI
encompass
concussion,
cerebral
hemorrhage,
tumors,
encephalitis,
delayed
apoptosis,
necrosis.
Current
treatment
methods,
such
as
pharmacotherapy
with
dihydropyridines,
high-pressure
oxygen
therapy,
behavioral
non-invasive
stimulation,
have
shown
limited
efficacy.
A
comprehensive
understanding
vascular
components
essential
for
developing
new
treatments
improve
blood
vessel-related
damage.
Recently,
mesenchymal
stem
cells
(MSCs)
promising
results
repairing
mitigating
Studies
indicate
MSCs
can
promote
neurogenesis
angiogenesis
through
various
mechanisms,
including
releasing
bioactive
molecules
extracellular
vesicles
(EVs),
which
help
reduce
neuroinflammation.
In
research,
the
distinctive
characteristics
positioned
them
highly
desirable
cell
sources.
Extensive
investigations
been
conducted
on
regulatory
properties
their
manipulation,
tagging,
transportation
techniques
brain-related
applications.
This
review
explores
progress
prospects
MSC
therapy
TBI,
focusing
action,
therapeutic
benefits,
challenges
potential
limitations
using
treating
neurological
disorders.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 12, 2024
Mortality
and
morbidity
from
cardiovascular
diseases
are
common
worldwide.
In
order
to
improve
survival
quality
of
life
for
this
patient
population,
extensive
efforts
being
made
establish
effective
therapeutic
modalities.
New
treatment
options
needed,
it
seems.
addition
treating
diseases,
cell
therapy
is
one
the
most
promising
medical
platforms.
One
approaches
in
area
stem
therapy.
biology,
multipotent
cells
pluripotent
divided
into
two
types.
There
evidence
that
could
be
used
as
a
approach
based
on
multiple
lines
evidence.
The
effectiveness
therapies
humans
has
been
studied
several
clinical
trials.
spite
challenges
associated
with
therapy,
appears
resolving
them
may
lead
disease
patients.
This
an
approach.
By
mounting
these
biological
scaffolds,
their
effect
can
enhanced.
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(1), С. 325 - 336
Опубликована: Янв. 16, 2025
Nanoparticles
have
become
a
transforming
platform
in
drug
delivery
systems.
Their
remarkable
advancement
over
traditional
methods
builds
upon
an
improvement
bioavailability,
stability,
and
controlled
of
therapeutic
agents.
Here,
we
discuss
the
broad
spectrum
potential
nanoparticle-based
Challenges,
innovations,
surface
modification
strategies
that
affect
their
clinical
translation
are
discussed.
Notwithstanding
they
present,
challenges
including
biocompatibility,
toxicity,
targeting
efficiency
persist
restricting
extensive
utilization.
The
review
emphasizes
recent
advancements,
stimuli-responsive
nanoparticles,
which
provide
release
reaction
to
environmental
triggers,
as
well
targeted
delivery,
facilitates
selective
accumulation
agents
at
designated
sites
disease.
Besides,
techniques,
such
PEGylation,
ligand
conjugation,
charge
modulation,
been
highly
promising
improving
stability
reducing
immunogenicity,
enhancing
cellular
uptake.
future
systems
based
on
nanoparticles
will
address
these
through
new
innovations
nanoparticle
design
effect
more
effective
treatments.
While
research
advances,
likely
bring
revolution
personalized
medicine,
tailoring
medical
therapy
for
different
diseases
with
minimal
side
effects
better
patient
outcomes.
