Genetic-bioengineering of nanotechnology in cell-specific pharmaceutical targeting: Biological, pharmacological, and biochemical impact of nanomaterials-based breast cancer therapies DOI
Javad Mohammadi, Sina Ebrahimi,

Maryam Ghodousi

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106249 - 106249

Опубликована: Окт. 1, 2024

Язык: Английский

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration DOI Creative Commons
Zahra Razavi,

Seyed Sina Alizadeh,

F. S. Razavi

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186

Опубликована: Янв. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Язык: Английский

Процитировано

12

Inorganic Nanoparticles and Blood-Brain Barrier Modulation: Advancing Targeted Neurological Therapies DOI
Zahra Razavi, F. S. Razavi,

Seyed Sina Alizadeh

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

6

CRISPR-Driven Biosensors: A New Frontier in Rapid and Accurate Disease Detection DOI

ZahraSadat Razavi,

M. Soltani, Mohammad Souri

и другие.

Critical Reviews in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 25

Опубликована: Сен. 17, 2024

This comprehensive review delves into the advancements and challenges in biosensing, with a strong emphasis on transformative potential of CRISPR technology for early rapid detection infectious diseases. It underscores versatility CRISPR/Cas systems, highlighting their ability to detect both nucleic acids non-nucleic acid targets, seamless integration isothermal amplification techniques. The provides thorough examination latest developments CRISPR-based biosensors, detailing unique properties such as high specificity programmability, which make them particularly effective detecting disease-associated acids. While focuses due its critical role diagnosing diseases, it also explores broader applications thereby acknowledging technology's potential. Additionally, identifies existing challenges, need improved signal real-world applicability, offers future perspectives aimed at overcoming these hurdles. ultimate goal is advance development highly sensitive specific biosensors that can be used widely improving human health, point-of-care settings resource-limited environments.

Язык: Английский

Процитировано

15

CRISPR innovations in tissue engineering and gene editing DOI Creative Commons

ZahraSadat Razavi,

M. Soltani, Mohammad Souri

и другие.

Life Sciences, Год журнала: 2024, Номер unknown, С. 123120 - 123120

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

11

Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges DOI Creative Commons

Kamran Sheikhi,

Sara Ghaderi,

Hassan Firouzi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 3, 2025

Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.

Язык: Английский

Процитировано

2

Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond DOI Creative Commons
Aref Yarahmadi,

Masoumeh Dorri Giv,

Reza Hosseininejad

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.

Язык: Английский

Процитировано

2

Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation DOI

Maryam Kananivand,

Fatemeh Nouri,

Mohammad Hasan Yousefi

и другие.

Journal of Molecular Histology, Год журнала: 2025, Номер 56(2)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1

Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights DOI Creative Commons
Zahra Razavi, Simin Farokhi, Golnaz Mahmoudvand

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Дек. 12, 2024

Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival quality of life for this patient population, extensive efforts being made establish effective therapeutic modalities. New treatment options needed, it seems. addition treating diseases, cell therapy is one the most promising medical platforms. One approaches in area stem therapy. biology, multipotent cells pluripotent divided into two types. There evidence that could be used as a approach based on multiple lines evidence. The effectiveness therapies humans has been studied several clinical trials. spite challenges associated with therapy, appears resolving them may lead disease patients. This an approach. By mounting these biological scaffolds, their effect can enhanced.

Язык: Английский

Процитировано

7

Advancements in photoacoustic imaging for cancer diagnosis and treatment DOI

Amirhamzeh Farajollahi,

Mohammad Baharvand

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124736 - 124736

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3

Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics DOI
Tasawar Abbas,

Fatima Kanwar,

Hazima Tariq

и другие.

Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 325 - 336

Опубликована: Янв. 16, 2025

Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.

Язык: Английский

Процитировано

0