International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 26, 2025
Abstract
Multiple
myeloma
(MM)
is
a
hematological
malignancy
defined
by
the
abnormal
proliferation
and
accumulation
of
plasma
cells
(PC)
within
bone
marrow
(BM).
While
multiple
impacts
bone,
it
not
classified
as
primary
cancer.
The
microenvironment
significantly
influences
progression
its
treatment
response.
Mesenchymal
stromal
(MSCs)
in
this
environment
engage
with
other
components
via
direct
contact
secretion
soluble
factors.
This
review
examines
established
roles
MSCs
facets
MM
pathology,
encompassing
their
pro-inflammatory
functions,
contributions
to
tumor
epigenetics,
effects
on
immune
checkpoint
inhibitors
(ICIs),
influence
reprogramming,
chemotherapy
resistance,
senescence.
investigates
role
development
MM.
