Clinical Nuclear Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Abstract
Candida
infections
have
become
a
growing
concern
to
the
immunocompromised
patients
with
cancer.
We
report
case
of
liver
abscess
causing
tropicalis
candidemia
in
an
patient
pancreatic
head
cancer
on
68
Ga-FAPI
PET/CT.
A
77-year-old
man
had
history
10-year
duration
uncontrolled
diabetes,
presence
neutropenia,
condition,
and
progression
despite
14
cycles
chemotherapy
palliative
radiotherapy.
After
3
weeks
radiotherapy,
he
presented
fever
elevated
CRP
level.
PET/CT
scan
showed
new
intense
uptake
liver,
2
pairs
blood
culture
revealed
C.
tropicalis.
Microorganisms,
Год журнала:
2024,
Номер
12(5), С. 927 - 927
Опубликована: Май 1, 2024
Candida
auris
has
been
identified
by
the
World
Health
Organization
(WHO)
as
a
critical
priority
pathogen
on
its
latest
list
of
fungi.
C.
infections
are
reported
in
bloodstream
and
less
commonly
cerebrospinal
fluid
abdomen,
with
mortality
rates
that
range
between
30%
72%.
However,
no
large-scale
epidemiology
studies
have
until
now.
The
diagnosis
can
be
challenging,
particularly
when
employing
conventional
techniques.
This
impede
early
detection
outbreaks
implementation
appropriate
control
measures.
yeast
easily
spread
patients
healthcare
settings
through
contaminated
environments
or
equipment,
where
it
survive
for
extended
periods.
Therefore,
would
desirable
to
screen
colonisation.
allow
facilities
identify
disease
take
prevention
It
is
frequently
unsusceptible
drugs,
varying
patterns
resistance
observed
among
clades
geographical
regions.
review
provides
updates
auris,
including
epidemiology,
clinical
characteristics,
genomic
analysis,
evolution,
colonisation,
infection,
identification,
profiles,
therapeutic
options,
prevention,
control.
Journal of Fungi,
Год журнала:
2025,
Номер
11(2), С. 133 - 133
Опубликована: Фев. 10, 2025
Invasive
candidiasis
is
a
common
fungal
infection
associated
with
multiple
risk
factors,
such
as
cancer,
neutropenia,
corticosteroid
therapy,
catheterization,
and
the
use
of
broad-spectrum
antibiotic
treatment.
Candida
albicans
predominant
causative
agent,
although
other
species
have
been
emerging
in
last
years,
together
rise
number
strains
resistant
to
currently
available
antifungal
drugs,
which
poses
challenge
when
treating
these
infections.
Drug
repurposing
drug
combinations
are
promising
strategies
for
treatment
invasive
mycoses.
In
this
study,
we
evaluated
effect
combination
fluconazole
(FLZ)
cyclosporine
A
(CsA)
against
39
clinical
isolates
reference
Candida.
Two
methods,
Loewe
additivity
model
Bliss
independence
model,
were
used
assess
activity
according
CLSI
EUCAST
guidelines.
The
results
demonstrated
synergistic
between
15–17
isolates,
depending
on
evaluation
used,
including
FLZ-resistant
C.
albicans,
glabrata,
parapsilosis,
tropicalis.
Notably,
significantly
reduced
minimum
inhibitory
concentration
(MIC)
FLZ
substantial
those
resistance
FLZ.
Additionally,
time–kill
curve
studies
confirmed
interaction,
further
validating
potential
an
alternative
therapeutic
strategy
These
findings
emphasize
importance
investigating
innovative
address
challenges
posed
by
improve
options
Diagnostics,
Год журнала:
2025,
Номер
15(8), С. 1001 - 1001
Опубликована: Апрель 14, 2025
Background:
Candida
infections
have
become
a
significant
cause
of
morbidity
and
mortality
in
pediatric
cardiac
intensive
care
units
following
congenital
heart
surgery,
ranking
among
the
most
common
causes
complications
this
patient
population.
There
is
paucity
information
available
regarding
epidemiology,
clinical
features,
risk
factors
associated
with
candidemia
The
present
study
evaluates
incidence
bloodstream
units.
Methods:
was
conducted
retrospectively
on
cases
patients
under
age
18
who
were
admitted
to
unit
between
1
January
2021
2024.
isolated
pathogens
recorded.
A
reanalysis
36
infections,
data
pertaining
age,
weight,
pathologies,
duration
mechanical
ventilation,
length
hospital
stay,
antibiotic
use
being
subjected
further
examination.
Each
case
matched
two
control
based
date
surgery.
results
analyzed
statistically.
Results:
total
identified
72
cases.
found
be
21.8
episodes
per
1000
admissions.
median
four
months.
species
blood
cultures
out
1650
(0.21%).
albicans
(n
=
12,
33.3%),
parapsilosis
16,
44.4%),
glabrata
2,
5.5%),
other
non-albicans
6,
16.6%)
isolated.
rate
61.1%
(22/36).
independent
as
candidemia:
birth
weight
less
than
2500
g
(OR:
3.2;
95%
confidence
interval
(CI):
2.5-5;
p
0.009),
RACHS-1
score
4
or
above
2.1;
CI:
1.3-6;
0.01),
cumulative
exposure
seven
days
more
2.5;
2-10;
<
0.001),
central
venous
catheterization
(CVC)
≥14
6.1;
4-18;
ventilation
dependency
≥10
4.2;
3-11;
requirement
for
parenteral
nutrition
9;
6-24;
delayed
sternal
closure
≥2
1.8;
1-4;
0.04).
Conclusions:
Postoperative
represents
complication
disease
(CHD),
different
potential
cause.
primary
that
contribute
likelihood
infection
these
are
low
high
score,
dependence
prolonged
antibiotics,
catheter
duration,
closure,
nutrition.
Diagnostics,
Год журнала:
2024,
Номер
14(20), С. 2343 - 2343
Опубликована: Окт. 21, 2024
Invasive
candidiasis
is
defined
as
an
important
infection
that
increases
the
duration
of
patients'
hospital
stay,
costs,
mortality
and
morbidity.
In
this
study,
we
aimed
to
investigate
frequency
in
blood
cultures
pediatric
hematology
patients,
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
Candida
albicans,
a
common
fungal
organism,
often
lives
harmlessly
in
the
human
body.
However,
under
certain
conditions,
it
can
turn
into
dangerous
pathogen,
causing
infections
that
range
from
mild
to
life-threatening.
With
rising
resistance
antifungal
treatments,
understanding
and
controlling
this
opportunistic
fungus
has
never
been
more
crucial.
This
study
highlights
potential
of
combining
natural
plant
extracts,
specifically
aqueous
(Jdext
Environment Conservation Journal,
Год журнала:
2024,
Номер
25(3), С. 795 - 807
Опубликована: Авг. 20, 2024
The
emergence
of
non-albicans
Candida
as
a
potential
causative
agent
candidiasis
following
albicans
is
occurring
globally.
It
known
that
phenolic
cresols,
thymol,
and
carvacrol
have
anti-Candida
characteristics.
However,
there
are
few
papers
disclose
the
mechanism
action,
which
characterized
by
damaged
cell
wall
ergosterol
synthesis,
well
calcium-induced
death
in
C.
albicans.
This
work
utilized
in-silico
docking
analysis
to
examine
molecular
targets
thymol
glabrata.
results
were
then
validated
vitro
antifungal
susceptibility
testing
growth
curve
analysis.
study
incorporated
glabrata
deletion
mutants
for
target
proteins
gain
understanding
function
these
effects
two
monoterpenoids.
After
conducting
silico
toxicity
evaluations,
chosen
investigations.
Experimental
tests
conducted
laboratory
setting
shown
both
phytocompounds
exhibit
strong
binding
affinity
towards
synthesis
(Kre1p,
Kre2p,
Ecm33p),
calcium
channel
(Mid1p,
Ecm7p),
involved
pathway
(Erg5p).
These
likely
be
specific
properties
isomeric
monoterpenoids
Minimum
inhibitory
concentration
(MIC50)
values
range
from
50
µg/ml
75
µg/ml.
wild-type
strains
minimum
fungicidal
100
125
carvacrol.
underscore
significance
fungal
reaction
also
indicate
promising
opportunity
development
novel
treatment
methods
utilizing
proteins.
