Advancements in metabolic engineering: unlocking the potential of key organic acids for sustainable industrial applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 11, 2025

This review explores the advancements, application potential, and challenges of microbial metabolic engineering strategies for sustainable organic acid production. By integrating gene editing, pathway reconstruction, dynamic regulation, platforms have achieved enhanced biosynthesis key acids such as pyruvate, lactic acid, succinic acid. Strategies including by-product knockout, enzyme overexpression, improved CO 2 fixation contributed to higher production efficiency. Additionally, utilizing non-food biomass sources, lignocellulose, algal feedstocks, industrial waste, has reduced reliance on conventional carbon supporting sustainability goals. However, remain in substrate inhibition, purification complexity, flux imbalances. Addressing these requires omics-driven optimization, stress-resistant strain development, biorefinery integration. Future research should focus system-level design enhance cost-effectiveness sustainability, advancing bio-manufacturing acids.

Язык: Английский

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Oil palm biomass: a potential feedstock for lignocellulolytic enzymes and biofuels production

Environmental Science and Pollution Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Sustainable Production of Microbial Biopolymer Utilizing Waste

Опубликована: Янв. 1, 2025

Язык: Английский

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