Advancements in metabolic engineering: unlocking the potential of key organic acids for sustainable industrial applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 11, 2025

This review explores the advancements, application potential, and challenges of microbial metabolic engineering strategies for sustainable organic acid production. By integrating gene editing, pathway reconstruction, dynamic regulation, platforms have achieved enhanced biosynthesis key acids such as pyruvate, lactic acid, succinic acid. Strategies including by-product knockout, enzyme overexpression, improved CO 2 fixation contributed to higher production efficiency. Additionally, utilizing non-food biomass sources, lignocellulose, algal feedstocks, industrial waste, has reduced reliance on conventional carbon supporting sustainability goals. However, remain in substrate inhibition, purification complexity, flux imbalances. Addressing these requires omics-driven optimization, stress-resistant strain development, biorefinery integration. Future research should focus system-level design enhance cost-effectiveness sustainability, advancing bio-manufacturing acids.

Language: Английский

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Oil palm biomass: a potential feedstock for lignocellulolytic enzymes and biofuels production

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Sustainable Production of Microbial Biopolymer Utilizing Waste

Published: Jan. 1, 2025

Language: Английский

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