A Review of the Biotechnological Potential of Cave Fungi: A Toolbox for the Future
Journal of Fungi,
Год журнала:
2025,
Номер
11(2), С. 145 - 145
Опубликована: Фев. 14, 2025
The
study
of
the
intersection
between
biodiversity
and
biotechnology
has
revealed
a
rich
source
innovations.
Fungi,
with
their
vast
range
morphologies
lifestyles,
thrive
in
various
habitats,
including
caves.
With
impressive
metabolic
characteristics,
they
play
key
role
producing
essential
biotechnological
compounds
for
economic
sectors.
This
paper
aims
to
consolidate
evidence
on
potential
fungi
isolated
from
caves,
highlighting
urgency
conserving
exploring
these
ecosystems.
For
this
purpose,
we
conducted
comprehensive
literature
search
using
scientific
databases
(SciELO,
Medline
Complete,
Medline/PubMed,
Web
Science,
Scopus
(Elsevier),
Google
Scholar).
We
adopted
an
interdisciplinary
approach
by
collecting
information
22
papers
published
2013
2024.
Based
data,
our
survey
broad
potential,
antimicrobial
compounds,
antioxidants,
antitumor
agents,
enzymes,
organic
acids.
emphasize
that
accurately
identifying
depositing
fungal
isolates
reference
collections
are
crucial
reliable
research
effective
industrial
applications,
driving
bioactivity
production
substances
inhibit
pathogens.
Conserving
protecting
cave
environment
is
imperative,
considering
its
continuous
discovery
contribution
advancement.
Язык: Английский
Research on the metabolites and key metabolic enzymes of allocryptopine in chicken liver microsomes via stable isotope tracing technology
Journal of Pharmaceutical and Biomedical Analysis,
Год журнала:
2025,
Номер
255, С. 116667 - 116667
Опубликована: Янв. 6, 2025
Язык: Английский
Naringenin-Loaded Solid Lipid Nanoparticles: Physical–Chemical Characterization and In Vitro Antibacterial Activity
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 232 - 232
Опубликована: Фев. 8, 2025
Currently,
problems
related
to
antibiotic
resistance
are
shifting
the
focus
of
pharmaceutical
research
towards
natural
molecules
with
antibacterial
properties.
Among
them,
flavonoids
represent
promising
strong
features;
however,
they
have
poor
biopharmaceutical
In
this
study,
we
developed
solid
lipid
nanoparticles
(SLNs)
loaded
flavanone
naringenin
(NRG)
offer
an
option
for
treating
bacterial
infections.
NRG-SLNs
systems
were
prepared
by
a
solvent
emulsification/diffusion
and
ultrasonication
method,
using
Compritol®
888
ATO
(COM)
as
lipid.
The
optimal
formulation
was
obtained
10%
(w/w)
theoretical
amount
NRG
(NRG10-SLNs),
exhibiting
homogeneous
sizes
(approximately
50
nm
0.15
polydispersity
index),
negative
zeta
potential
(-30
mV),
excellent
encapsulation
parameters
(an
efficiency
percentage
97.9%
drug
content
4%).
NRG10-SLNs
presented
good
physical
stability
over
4
weeks.
A
cumulative
release
55%
in
24
h
prolonged
remaining
10
days
observed.
addition,
µ-Raman
spectroscopy,
differential
scanning
calorimetry,
thermogravimetric
analysis,
X-ray
diffraction
measurements
carried
out
characterize
drug-lipid
interactions.
Finally,
vitro
antibiofilm
activities
assayed
compared
free
NRG.
bacteriostatic
against
Staphylococcus
aureus,
including
methicillin-resistant
S.
aureus
(MRSA)
Escherichia
coli
strains.
An
improvement
activity
NRG-loaded
SLNs
molecule
observed
strains,
probably
due
interaction
surfactant-coated
surface.
similar
trend
biofilm
inhibition.
Язык: Английский
Comprehensive Overview of Antibacterial Drugs and Natural Antibacterial Compounds Found in Food Plants
Antibiotics,
Год журнала:
2025,
Номер
14(2), С. 185 - 185
Опубликована: Фев. 11, 2025
The
aim
of
this
review
is
to
list
the
various
natural
sources
antimicrobials
that
are
readily
available.
Indeed,
many
plant
known
have
antibiotic
properties,
although
it
not
always
clear
which
molecule
responsible
for
activity.
Many
food
supplements
also
therapeutic
indication.
We
propose
here
take
stock
scientific
knowledge
attesting
or
these
indications
some
sources.
An
overview
drugs
commercially
available
will
be
provided.
A
structural
indication
molecules
present
in
plants
and
reported
contribute
their
power
given.
mentioned
review,
does
claim
exhaustive,
referenced
fighting
Gram-positive
and/or
Gram-negative
bacteria.
It
difficult
attribute
activity
just
one
molecules,
as
likely
result
from
synergy
within
plant.
Similarly,
chitosan
its
fungistatic
bacteriostatic
properties.
In
case,
polymeric
compound
derived
chitin
marine
organisms
antibiofilm
seems
that,
face
growing
resistance,
makes
sense
keep
high-performance
synthetic
antibiotics
on
hand
treat
pathologies
require
them.
On
other
hand,
minor
infections,
use
better-tolerated
certainly
sufficient.
To
achieve
this,
we
need
common
sources,
products
dietary
supplements,
active
field.
Язык: Английский
Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies
BMC Microbiology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 9, 2025
Pseudomonas
aeruginosa
can
proliferate
in
immunocompromised
individuals,
forming
biofilms
that
increase
antibiotic
resistance.
This
bacterium
poses
a
significant
global
health
risk
due
to
its
resistance
human
defenses,
antibiotics,
and
various
environmental
stresses.
The
objective
of
this
study
was
evaluate
the
antibacterial,
anti-biofilm,
anti-quorum
sensing
activities
galloylquinic
acid
compounds
(GQAs)
extracted
from
Copaifera
lucens
leaves
against
clinical
isolates
multidrug-resistant
(MDR)
P.
aeruginosa.
We
have
investigated
optimal
concentration
GQAs
needed
eradicate
preexisting
manage
wound
infections
caused
by
aeruginosa,
vitro
vivo.
Our
results
revealed
exhibited
25-40
mm
inhibition
zone
diameters,
with
1-4
µg/mL
MIC
2-16
MBC
values.
interfered
planktonic
mode
isolates,
significantly
inhibited
their
growth
pre-formed
biofilm
architecture,
MBIC80
MBEC80
values
64
128
µg/mL,
respectively.
anti-biofilm
effect
confirmed
fluorescence
staining
confocal
microscopy
which
showed
dramatic
reduction
cell
viability
thickness
(62.5%),
after
exposure
particular.
scanning
electron
micrographs
impaired
bacterial
structures
interfering
biomass
exopolysaccharides
matrix.
also
virulence
factors
motility,
where
(p
<
0.05)
reduced
rhamnolipid,
pyocyanin,
swarming
motility
organism
play
vital
role
formation.
downregulated
89%
quorum-sensing
genes
(lasI
lasR,
pqsA
pqsR)
involved
demonstrate
promise
as
novel
potent
antibiofilm
antivirulence
agents
MDR
substantial
potential
enhance
healing
biofilm-associated
infections.
promising
antibacterial
action
positions
superior
alternative
for
treatment
infections,
improve
mitigate
impact
persistent
not
applicable.
Язык: Английский
Bioinspired Nanomaterials to Combat Microbial Biofilm and Pathogen Challenges: A Review
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(22), С. 25287 - 25313
Опубликована: Ноя. 12, 2024
The
emergence
of
antibiotic-resistant
biofilms
poses
a
significant
challenge
in
healthcare,
as
these
complex
microbial
communities
demonstrate
an
increased
resistance
to
conventional
treatment
methods.
Traditional
antibiotics
often
fail
against
biofilms,
resulting
persistent
infections
and
failures.
To
address
this
urgent
issue,
innovative
strategies
such
bioinspired
nanomaterials,
antimicrobial
peptides,
quorum
sensing
inhibitors,
combination
therapies
show
promise
disrupting
biofilm
structures,
enhancing
activity,
overcoming
mechanisms.
Bioinspired
nanomaterials
have
emerged
pivotal
approach
for
tackling
the
challenges
presented
by
pathogens
across
various
sectors,
including
industry,
environmental
protection.
Their
advantages
include
enhanced
biocompatibility,
targeted
delivery,
improved
efficacy
formation
threats.
Recent
advancements
highlight
potential
solutions,
nanoparticles,
smart
nanocarriers,
surface
modifications,
nanozymes,
combating
biofilm-related
issues.
Despite
progress
nanomaterial
research,
remain.
intricate
interactions
within
evolving
nature
necessitate
multidisciplinary
approaches.
Furthermore,
translating
laboratory
findings
into
practical
applications
faces
obstacles
related
scalability,
stability,
regulatory
compliance.
Future
are
expected
focus
on
multifunctional
nanoparticles
that
disrupt
advanced
modifications
better
interaction,
nanocarriers
nanozymes
dismantle
structures.
This
review
focuses
development
application
pathogen
challenges.
It
emphasizes
roles
targeting
capabilities.
Additionally,
explores
formulating
management
practices,
providing
insights
advantages,
limitations,
future
perspectives
Язык: Английский
Lipid Nanoparticle Formulations for the Skin Delivery of Cannabidiol
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1490 - 1490
Опубликована: Ноя. 21, 2024
Background/Objectives:
The
aims
of
this
work
were
to
formulate
cannabidiol
in
different
lipid
carriers
for
skin
delivery
after
topical
application
and
study
their
stability,
interaction
with
the
skin,
antibacterial
activity.
Methods:
Solid
nanoparticles
nanostructured
loaded
prepared
characterized
terms
physicochemical
properties,
colloidal
protection
antioxidant
capacity
cannabidiol,
as
well
retention
over
time.
Skin
penetration
was
assessed
using
an
vitro
model
human
skin.
activity
tested
against
Staphylococcus
aureus
compared
free
cannabidiol.
Results:
Three
nanoformulations
exhibited
best
size
reproducibility
values
selected
further
studies.
formulations
stable,
protected
active
ingredient,
succeeded
delivering
it
deep
layers,
demonstrated
Conclusions:
These
show
potential
use
diseases
conditions,
they
protect
enhance
its
exhibit
effects.
Язык: Английский
Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum
Open Chemistry,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 1, 2024
Abstract
The
objective
of
this
investigation
was
to
assess
the
inhibitory
effects
extracts
derived
from
Pterospermum
heterophyllum
on
bacteria
and
fungi,
as
well
their
capacity
impede
proliferation
migration
HepG2
liver
cancer
cells.
Extracts
leaves
stems
P.
revealed
ability
resist
all
three
bacterial
strains,
including
Escherichia
coli
,
Pseudomonas
aeruginosa
Streptococcus
aureus
(
p
<
0.05).
Additionally,
also
inhibited
growth
fungal
strains:
Aspergillus
brasiliensis
Candida
albicans
flavus
.
Evaluation
anticancer
activity
showed
that
significantly
reduced
cells,
with
IC
50
values
for
leaf
stem
being
35.5
47.17
µg/mL,
respectively.
Remarkably,
extract
herbal
species
cells
after
24
h
treatment.
Fluorescence
analysis
using
2-HDCFDA
a
considerable
elevation
in
reactive
oxygen
production
within
treated
extracts,
which
is
hypothesized
contribute
reduction
cell
viability.
Subsequent
chemical
compound
utilizing
GC-FID
spectra
identified
some
main
compounds
present
This
study
highlights
potential
antimicrobial
activities
Язык: Английский