Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 6
Опубликована: Окт. 23, 2024
Glycoabyssomicin
A
(1),
a
new
type
of
abyssomicin
containing
sugar
unit,
was
isolated
from
the
deep-sea
derived
Streptomyces
koyangensis
SCSIO
5802
guided
by
LC-MS.
The
structure
1
elucidated
HR-ESI-MS,
1D-NMR
(1H,13C
NMR),
2D-NMR
(HSQC,
COSY,
HMBC,
NOESY),
and
TFA
hydrolysis
acetylation
reactions.
In
antibacterial
activities
evaluation
against
series
gram-positive
gram-negative
bacteria,
it
showed
inactive
at
concentration
10
μg
per
filter
paper
disc.
This
finding
would
broaden
way
for
discovery
more
lead
compounds
abyssomicins.
Applied Microbiology and Biotechnology,
Год журнала:
2024,
Номер
108(1)
Опубликована: Фев. 5, 2024
Abstract
Diketopiperazine
alkaloids
have
proven
the
most
abundant
heterocyclic
up
to
now,
which
usually
process
diverse
scaffolds
and
rich
biological
activities.
In
our
search
for
bioactive
diketopiperazine
from
marine-derived
fungi,
two
novel
alkaloids,
penipiperazine
A
(
1
)
its
biogenetically
related
new
metabolite
2
),
together
with
a
known
analogue
neofipiperzine
C
3
were
obtained
strain
Penicillium
brasilianum
.
Their
planar
structures
absolute
configurations
elucidated
by
extensive
spectroscopic
analyses,
13
NMR
calculation,
Marfey’s,
ECD,
ORD
methods.
Compound
featured
unique
6/5/6/6/5
indole-pyrazino-pyrazino-pyrrolo
system,
plausible
biogenetic
pathway
was
also
proposed.
Additionally,
compounds
–
been
tested
their
inflammatory
significantly
inhibited
release
of
NO
expression
pro-inflammatory
cytokines
on
LPS-stimulated
RAW264.7
cells,
suggesting
they
could
be
attracting
candidate
further
development
as
anti-inflammatory
agent.
Key
points
•
alkaloid
featuring
system
isolated
marine
fungus
brasilianum.
The
structure
detailed
analysis
2D
data,
Compounds
cells.
Graphical
Marine Drugs,
Год журнала:
2024,
Номер
22(10), С. 433 - 433
Опубликована: Сен. 25, 2024
Inflammation
is
considered
as
one
of
the
most
primary
protective
innate
immunity
responses,
closely
related
to
body’s
defense
mechanism
for
responding
chemical,
biological
infections,
or
physical
injuries.
Furthermore,
prolonged
inflammation
undesirable,
playing
an
important
role
in
development
various
diseases,
such
heart
disease,
diabetes,
Alzheimer’s
atherosclerosis,
rheumatoid
arthritis,
and
even
certain
cancers.
Marine-derived
fungi
represent
promising
sources
structurally
novel
bioactive
natural
products,
have
been
a
focus
research
anti-inflammatory
drugs.
This
review
covers
secondary
metabolites
with
activities
from
marine-derived
fungi,
over
period
spanning
August
2018
July
2024.
A
total
285
metabolites,
including
156
compounds
11
skeleton
structures,
are
described.
Their
structures
categorized
into
five
categories:
terpenoids,
polyketides,
nitrogen-containing
compounds,
steroids,
other
classes.
The
targets,
well
vitro
vivo
screening
models,
were
surveyed
statistically
summarized.
paper
aims
offer
valuable
insights
researchers
exploration
products
discovery
Marine Drugs,
Год журнала:
2024,
Номер
22(8), С. 348 - 348
Опубликована: Июль 29, 2024
The
increase
in
antimicrobial
resistance
(AMR)
microorganisms
is
a
significant
global
health
concern.
Various
factors
contribute
to
AMR,
including
alterations
cell
membrane
permeability,
increased
efflux
pump
activity,
enzymatic
modification
or
inactivation
of
antibiotics,
target
site
changes,
alternative
metabolic
pathways,
and
biofilm
formation.
Marine
environments,
with
their
extensive
biodiversity,
provide
valuable
source
natural
products
wide
range
biological
activities.
Marine-derived
compounds
show
potential
against
drug-resistant
bacteria
fungi.
This
review
discusses
the
current
knowledge
on
marine
such
as
microorganisms,
sponges,
tunicates
mollusks
antibacterial
antifungal
properties
effective
ecological
roles.
These
are
classified
based
chemical
structures,
alkaloids,
amino
acids,
peptides,
polyketides,
naphthoquinones,
terpenoids,
polysaccharides.
Although
still
preclinical
studies,
these
agents
demonstrate
promising
vivo
efficacy,
suggesting
that
sources
could
be
pivotal
developing
new
drugs
combat
thereby
fulfilling
an
essential
medical
need.
highlights
ongoing
importance
biodiversity
exploration
for
discovering
agents.
Marine Life Science & Technology,
Год журнала:
2024,
Номер
6(3), С. 502 - 514
Опубликована: Авг. 5, 2024
As
one
of
the
common
malignancies
that
threaten
human
life,
bladder
cancer
occurs
frequently
with
a
high
mortality
rate
in
world,
due
to
its
invasion,
recurrence
and
drug
resistance.
Natural
products
from
marine
microorganisms
are
becoming
hotspots
discovery
new
candidate
entities,
especially
area
cancer.
Brefeldin
A
(BFA)
is
natural
Arf-GEFs
inhibitor,
but
low
aqueous
solubility,
strong
toxicity,
poor
bioavailability,
it
urgent
conduct
structural
optimization
research.
Herein,
BFA
pyridine
acrylate
derivative
Medicinal Research Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
5-(3'-Indolyl)oxazole
moiety
is
a
privileged
heterocyclic
scaffold,
embedded
in
many
biologically
interesting
natural
products
and
potential
therapeutic
agents.
Compounds
containing
this
whether
from
sources
or
synthesized,
have
demonstrated
wide
array
of
biological
activities.
This
has
piqued
the
interest
synthetic
chemists,
leading
to
large
number
reported
approaches
5-(3'-indolyl)oxazole
scaffold
recent
years.
In
review,
we
comprehensively
overviewed
different
activities
chemical
methods
for
literatures
1963
2024.
The
focus
study
highlight
significance
derivatives
as
lead
compounds
discovery
anticancer,
pesticidal,
antimicrobial,
antiviral,
antioxidant
anti-inflammatory
agents,
summarize
scaffold.
addition,
mechanism
action
5-(3'-indolyl)oxazoles
advanced
molecules
studied
animal
models
are
also
reviewed.
Furthermore,
review
offers
perspectives
on
how
structure
might
be
exploited
future.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 19, 2024
Bacterial
infections
pose
a
significant
clinical
burden
on
global
health.
The
growing
incidence
of
drug-resistant
pathogens
highlights
the
critical
necessity
to
identify
and
isolate
bioactive
compounds
from
marine
resources.
Marine-derived
fungi
could
provide
novel
lead
against
pathogenic
bacteria.
Due
particularity
environment,
Aspergillus
species
derived
sources
have
proven
be
potent
producers
secondary
metabolites
played
considerable
role
in
advancing
drug
development.
This
study
reviews
structural
diversity
activities
bacteria
isolated
marine-derived
over
past
14
years
(January
2010–June
2024),
337
natural
products
(including
145
new
compounds)
were
described.
structures
divided
into
five
major
categories—terpenoids,
nitrogen-containing
compounds,
polyketides,
steroids,
other
classes.
These
antimicrobial
will
offer
development
innovation
agents.
