Pre-eclampsia, gestational hypertension, and lipid levels during pregnancy: a systematic review and meta-analysis DOI Creative Commons
Xue Qin,

Fangfang Ai,

Qi Zhou

и другие.

Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Gestational hypertension (GH) and pre-eclampsia (PE) are common high-risk complications of pregnancy, also one the important causes global maternal mortality perinatal mortality. It has been suggested that abnormal lipid metabolism may play a key role in pathogenesis GH PE. However, results different studies controversial lack systematic quantitative analysis. The aim this study is to evaluate differences levels between patients with PE healthy controls by meta-analysis, explore potential disease. In study, PubMed, EMBASE, Cochrane Library, CNKI, other Chinese English databases were searched. subjects included hypertensive disorders during pregnancy (including pre-eclampsia) controls. To triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density (LDL) review meta-analysis. Revman software was used calculate standardized mean difference (SMD) its 95% confidence interval (CI). Heterogeneity evaluated I2 statistic Q test. Publication bias sensitivity analysis performed. (1) A 5 meta-analysis gestational profile including 321 1171 pregnant women. 7 1114 women 32,537 (2) showed HDL significantly lower than those control group (SMD = - 0.20, CI 0.35 0.06, P 0.006), while LDL 1.40, 1.22 1.59, < 0.00001), TC 0.37, 0.23 0.51, TG 0.64, 0.50 0.79, 0.00001) elevated. (3) -0.30 mmol/L, 0.36, 0.11, 0.25, 0.18, 0.31, 0.27 0.21, 0.22, 1.15, 9% 0.55, 1.74, 0.0002) increased. moderate-to-high heterogeneity some indicators (I2 range: 56-99%). No significant found publication test, robust. This suggests be an feature pre-eclampsia, suggesting dynamic monitoring clinical value for early prediction management decrease level impair vascular protective function, increase LDL, TC, aggravate endothelial dysfunction oxidative stress, thereby affecting placental perfusion function.

Язык: Английский

Macrophages in graft-versus-host disease (GVHD): dual roles as therapeutic tools and targets DOI Creative Commons
Atieh Raoufi, Hamed Soleimani Samarkhazan, S Nouri

и другие.

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Март 6, 2025

Graft-versus-host disease remains one of the most formidable barriers to complete success hematopoietic stem cell transplantation that has emerged as curative approach for many malignancies because it affects quality life and overall survival. Macrophages are among important members immune system, which perform dual roles in GVHD both therapeutic tools targets. This review epitomizes multifunctional role macrophages pathophysiology acute chronic GVHD. play an early phase their recruitment infiltration into target organs. Furthermore, they polarize two functionally different phenotypes, including M1 M2. In case GVHD, express phenotype characterized by production pro-inflammatory cytokines contribute tissue damage. contrast, tend toward M2 associated with repair tissues fibrosis. A critical balance these phenotypes is central course severity Further interactions other lymphocytes such T cells, B fibroblast further determine Macrophage interaction alloreactive cells promotes inflammation. therefore inducing injuries during Interaction macrophages, cell, fibroblast, CD4+ fibrosis and, hence, subsequent dysfunction These some insights, while several challenges remain. First, impact dominant on polarization incompletely sometimes controversial. Second, development targeted therapies able modulate macrophage function without systemic side effects area ongoing investigation. Future directions involve exploration macrophage-targeted therapies, small molecules, antibodies, nanotechnology, behavior improve patient outcomes. underlines fact a profound understanding essential developing new more effective strategies. Targeting might represent avenue decreasing incidence improving safety HSCT.

Язык: Английский

Процитировано

7
VEGF-A in COVID-19: a systematic review and meta-analytical approach to its prognostic value DOI Creative Commons
Seyed Sobhan Bahreiny, Mohammad‐Navid Bastani, Hossein Keyvani

и другие.

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Март 12, 2025

Abstract Numerous studies have reported vascular endothelial growth factor A (VEGF-A) has a significant impact on the pathophysiology of COVID-19. The objective this systematic review and meta-analysis is to determine prognostic value increased levels VEGF-A in individuals with literature search was conducted across multiple electronic databases, including PubMed, Web Science, Cochrane Library, Scopus, EMBASE, Google Scholar, up January 2024. Studies examining serum or plasma COVID-19 patients were incorporated, specific attention given contrasting severe/critical cases against moderate cases. Standardized mean differences (SMD) 95% confidence intervals (CIs) calculated using random-effects model overall effect sizes. Meta-regressions subgroup analyses performed explore potential sources heterogeneity. synthesized data from 11 involving total 1119 patients. Elevated significantly associated disease severity, pooled SMD 0.525 (95% CI 0.239–0.058; P = 0.028). Research indicated that nature relationship differs among various age groups, there minor discrepancies techniques employed obtain measurements. Furthermore, meta-regression analysis correlation between assay technique body mass index (BMI). This provides compelling evidence for potency Understanding intricate interplay holds promise development targeted therapeutic strategies indicators management

Язык: Английский

Процитировано

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Methods: Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. Results: A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Conclusion: Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Язык: Английский

Процитировано

0
The effects of transdermal estrogens combined with Medroxyprogesterone Acetate on cardiovascular disease risk factors in postmenopausal women: a meta-analysis of randomized controlled trials DOI Creative Commons
Fan Zhou, Kousalya Prabahar,

鮫島 夏樹

и другие.

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 1, 2025

To date, no meta-analysis has reported on the role of transdermal estrogens combined with Medroxyprogesterone Acetate (MPA) in relation to cardiovascular disease (CVD) risk factors postmenopausal women. fill this knowledge gap, a randomized controlled trials (RCTs) was conducted assess effects and MPA CVD A systematic literature search major databases including PubMed/Medline, Web Science, SCOPUS, Embase, from inception 12 February 2025. The combination Medical Subject Headings (MeSH) non-MeSH keywords used. total 14 were included meta-analysis. eligible found that significantly decreased cholesterol (TC) (WMD: -13.37 mg/dL, 95% CI: -21.54 -5.21, p = 0.001), low density lipoprotein (LDL-C) -12.17 -23.26 -1.08, 0.031), apolipoprotein B (ApoB) -7.26 -11.48 -3.03, 0.001) compared control. No statistically significant associations observed between triglyceride (TG), high (HDL-C), lipoprotein(a) (Lp(a)), A1 (ApoAI). Based results current meta-analysis, oral administration had beneficial effect certain women, as evidenced by reductions TC, LDL-C, ApoB.

Язык: Английский

Процитировано

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 14, 2025

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Язык: Английский

Процитировано

0
The Impact of Physical Exercise on Male Fertility Through Its Association with Various Processes and Aspects of Human Biology DOI Open Access
Adrianna Zańko, Michał Pawłowski, Robert Milewski

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(10), С. 3442 - 3442

Опубликована: Май 14, 2025

Background/Objective: Infertility affects approximately 10–15% couples in industrialized countries. It has numerous causes, including genetic and environmental factors, lifestyle choices, physiological disorders. The increasing prevalence of infertility underlines the importance research into interventions to improve reproductive health, with a strong focus on physical activity. was traditionally mainly directed toward female health. Although male factor is being increasingly accepted as equally important, this area remains under-researched. current review focuses impact activity fertility through its effects immune function, cardiovascular system, hormonal balance, metabolism, interaction system. Materials Methods: A comprehensive literature studies addressing conducted using PubMed/Medline, Scopus, Web Science. Mostly recent were included, small number older ones included cases when their content relevant. focused articles studying processes involved associations between effects, endocrine modulation, influence obesity insulin body. Results: findings revealed existence fairly consensus that moderate enhances semen quality, metabolic positively influencing fertility. Physical reduces inflammation oxidative stress, functioning, contributes oxygen nutrient supply organs. On contrary, strenuous training can adversely affect fertility, mostly disruption stress. also have various indirect sports-related behavior incidents, such wearing tight-fitting clothes or overheating. Conclusions: ways, health performed at intensity. Understanding balance beneficial excessive exercise well incidental factors related performing sports regularly are, thus, extremely important optimizing lifestyle-oriented aimed improvement.

Язык: Английский

Процитировано

0
Pre-eclampsia, gestational hypertension, and lipid levels during pregnancy: a systematic review and meta-analysis DOI Creative Commons
Xue Qin,

Fangfang Ai,

Qi Zhou

и другие.

Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Gestational hypertension (GH) and pre-eclampsia (PE) are common high-risk complications of pregnancy, also one the important causes global maternal mortality perinatal mortality. It has been suggested that abnormal lipid metabolism may play a key role in pathogenesis GH PE. However, results different studies controversial lack systematic quantitative analysis. The aim this study is to evaluate differences levels between patients with PE healthy controls by meta-analysis, explore potential disease. In study, PubMed, EMBASE, Cochrane Library, CNKI, other Chinese English databases were searched. subjects included hypertensive disorders during pregnancy (including pre-eclampsia) controls. To triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density (LDL) review meta-analysis. Revman software was used calculate standardized mean difference (SMD) its 95% confidence interval (CI). Heterogeneity evaluated I2 statistic Q test. Publication bias sensitivity analysis performed. (1) A 5 meta-analysis gestational profile including 321 1171 pregnant women. 7 1114 women 32,537 (2) showed HDL significantly lower than those control group (SMD = - 0.20, CI 0.35 0.06, P 0.006), while LDL 1.40, 1.22 1.59, < 0.00001), TC 0.37, 0.23 0.51, TG 0.64, 0.50 0.79, 0.00001) elevated. (3) -0.30 mmol/L, 0.36, 0.11, 0.25, 0.18, 0.31, 0.27 0.21, 0.22, 1.15, 9% 0.55, 1.74, 0.0002) increased. moderate-to-high heterogeneity some indicators (I2 range: 56-99%). No significant found publication test, robust. This suggests be an feature pre-eclampsia, suggesting dynamic monitoring clinical value for early prediction management decrease level impair vascular protective function, increase LDL, TC, aggravate endothelial dysfunction oxidative stress, thereby affecting placental perfusion function.

Язык: Английский

Процитировано

0