Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Language: Английский

Macrophages in graft-versus-host disease (GVHD): dual roles as therapeutic tools and targets DOI Creative Commons
Atieh Raoufi, Hamed Soleimani Samarkhazan, S Nouri

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Graft-versus-host disease remains one of the most formidable barriers to complete success hematopoietic stem cell transplantation that has emerged as curative approach for many malignancies because it affects quality life and overall survival. Macrophages are among important members immune system, which perform dual roles in GVHD both therapeutic tools targets. This review epitomizes multifunctional role macrophages pathophysiology acute chronic GVHD. play an early phase their recruitment infiltration into target organs. Furthermore, they polarize two functionally different phenotypes, including M1 M2. In case GVHD, express phenotype characterized by production pro-inflammatory cytokines contribute tissue damage. contrast, tend toward M2 associated with repair tissues fibrosis. A critical balance these phenotypes is central course severity Further interactions other lymphocytes such T cells, B fibroblast further determine Macrophage interaction alloreactive cells promotes inflammation. therefore inducing injuries during Interaction macrophages, cell, fibroblast, CD4+ fibrosis and, hence, subsequent dysfunction These some insights, while several challenges remain. First, impact dominant on polarization incompletely sometimes controversial. Second, development targeted therapies able modulate macrophage function without systemic side effects area ongoing investigation. Future directions involve exploration macrophage-targeted therapies, small molecules, antibodies, nanotechnology, behavior improve patient outcomes. underlines fact a profound understanding essential developing new more effective strategies. Targeting might represent avenue decreasing incidence improving safety HSCT.

Language: Английский

Citations

1
VEGF-A in COVID-19: a systematic review and meta-analytical approach to its prognostic value DOI Creative Commons
Seyed Sobhan Bahreiny, Mohammad‐Navid Bastani, Hossein Keyvani

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 12, 2025

Abstract Numerous studies have reported vascular endothelial growth factor A (VEGF-A) has a significant impact on the pathophysiology of COVID-19. The objective this systematic review and meta-analysis is to determine prognostic value increased levels VEGF-A in individuals with literature search was conducted across multiple electronic databases, including PubMed, Web Science, Cochrane Library, Scopus, EMBASE, Google Scholar, up January 2024. Studies examining serum or plasma COVID-19 patients were incorporated, specific attention given contrasting severe/critical cases against moderate cases. Standardized mean differences (SMD) 95% confidence intervals (CIs) calculated using random-effects model overall effect sizes. Meta-regressions subgroup analyses performed explore potential sources heterogeneity. synthesized data from 11 involving total 1119 patients. Elevated significantly associated disease severity, pooled SMD 0.525 (95% CI 0.239–0.058; P = 0.028). Research indicated that nature relationship differs among various age groups, there minor discrepancies techniques employed obtain measurements. Furthermore, meta-regression analysis correlation between assay technique body mass index (BMI). This provides compelling evidence for potency Understanding intricate interplay holds promise development targeted therapeutic strategies indicators management

Language: Английский

Citations

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Methods: Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. Results: A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Conclusion: Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Language: Английский

Citations

0
The effects of transdermal estrogens combined with Medroxyprogesterone Acetate on cardiovascular disease risk factors in postmenopausal women: a meta-analysis of randomized controlled trials DOI Creative Commons
Fan Zhou, Kousalya Prabahar,

鮫島 夏樹

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 1, 2025

To date, no meta-analysis has reported on the role of transdermal estrogens combined with Medroxyprogesterone Acetate (MPA) in relation to cardiovascular disease (CVD) risk factors postmenopausal women. fill this knowledge gap, a randomized controlled trials (RCTs) was conducted assess effects and MPA CVD A systematic literature search major databases including PubMed/Medline, Web Science, SCOPUS, Embase, from inception 12 February 2025. The combination Medical Subject Headings (MeSH) non-MeSH keywords used. total 14 were included meta-analysis. eligible found that significantly decreased cholesterol (TC) (WMD: -13.37 mg/dL, 95% CI: -21.54 -5.21, p = 0.001), low density lipoprotein (LDL-C) -12.17 -23.26 -1.08, 0.031), apolipoprotein B (ApoB) -7.26 -11.48 -3.03, 0.001) compared control. No statistically significant associations observed between triglyceride (TG), high (HDL-C), lipoprotein(a) (Lp(a)), A1 (ApoAI). Based results current meta-analysis, oral administration had beneficial effect certain women, as evidenced by reductions TC, LDL-C, ApoB.

Language: Английский

Citations

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Language: Английский

Citations

0