Chemico-Biological Interactions, Год журнала: 2021, Номер 351, С. 109768 - 109768
Опубликована: Дек. 3, 2021
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116827 - 116827
Опубликована: Июнь 10, 2024
Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, underscoring the importance understanding diverse molecular and genetic underpinnings CRC to improve its diagnosis, prognosis, treatment. This review delves into adenoma-carcinoma-metastasis model, emphasizing "APC-KRAS-TP53" signature events in development. categorized four consensus subtypes, each characterized by unique alterations responses therapy, illustrating complexity heterogeneity. Furthermore, we explore role chronic inflammation gut microbiome progression, potential targeting these factors for prevention discusses impact dietary carcinogens lifestyle critical early detection improving outcomes, also examines conventional chemotherapy options associated challenges. There significant focus on therapeutic flavonoids management, discussing various types flavonoids, their sources, mechanisms action, including antioxidant properties, modulation cell signaling pathways, effects cycle apoptosis. article presents evidence synergistic with therapies modulating immune response, thereby offering new avenues We conclude multidisciplinary approach research treatment, incorporating insights from genetic, molecular, factors. Further needed preventive natural compounds, such as CRC, need personalized targeted treatment strategies.
Язык: Английский
Процитировано
5
ACS Synthetic Biology, Год журнала: 2024, Номер 13(9), С. 2667 - 2683
Опубликована: Авг. 15, 2024
Flavonoids, a significant group of natural polyphenolic compounds, possess broad spectrum pharmacological effects. Recent advances in the systematic metabolic engineering yeast cell factories (YCFs) provide new opportunities for enhanced flavonoid production. Herein, we outline latest research progress on typical products YCFs. Advanced strategies involved biosynthesis are discussed detail, including enhancing precursor supply, cofactor engineering, optimizing core pathways, eliminating competitive relieving transport limitations, and dynamic regulation. Additionally, highlight existing problems glucosides yeast, such as endogenous degradation glycosides, substrate promiscuity UDP-glycosyltransferases, an insufficient supply UDP-sugars, with summaries corresponding solutions. Discussions also cover other postmodifications like prenylation methylation, recent complex compounds yeast. Finally, series advanced technologies envisioned, i.e., semirational enzyme ML/DL algorithn, systems biology, aspiration achieving large-scale industrial production future.
Язык: Английский
Процитировано
5
Molecules, Год журнала: 2025, Номер 30(5), С. 1058 - 1058
Опубликована: Фев. 26, 2025
The Epstein-Barr virus (EBV), a member of the human gamma-herpesviruses, is intricately linked to various malignancies. Current treatment options for EBV infection involve use acyclovir and its derivatives, which exhibit limited efficacy are associated with drug resistance issues. Therefore, there critical need new medications more effective therapeutic actions less susceptibility resistance. This review explores promise flavones flavonols, naturally occurring molecules, against correlated cancers. It thoroughly delves into molecular mechanisms underlying these compounds scrutinizes their complex interplay in EBV-linked processes cancer transformation by targeting key genes proteins pivotal both viral life cycle tumor development. Additionally, covers current research, highlights findings, discusses promising avenues future investigations pursuit targeted therapies related tumors.
Язык: Английский
Процитировано
0
South African Journal of Chemical Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Chemico-Biological Interactions, Год журнала: 2021, Номер 351, С. 109768 - 109768
Опубликована: Дек. 3, 2021
Язык: Английский
Процитировано
28