Recent selection and introgression facilitated high-altitude adaptation in cattle

Science Bulletin, Год журнала: 2024, Номер 69(21), С. 3415 - 3424

Опубликована: Май 25, 2024

Язык: Английский

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Beef Cattle Genome Project: Advances in Genome Sequencing, Assembly, and Functional Genes Discovery

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7147 - 7147

Опубликована: Июнь 28, 2024

Beef is a major global source of protein, playing an essential role in the human diet. The worldwide production and consumption beef continue to rise, reflecting significant trend. However, despite critical importance cattle resources agriculture, diversity breeds faces severe challenges, with many at risk extinction. initiation Cattle Genome Project crucial. By constructing high-precision functional annotation map their genome, it becomes possible analyze genetic mechanisms underlying important traits cattle, laying solid foundation for breeding more efficient productive breeds. This review details advances genome sequencing assembly technologies, iterative upgrades reference its application pan-genome research. Additionally, summarizes relevant studies on discovery genes associated key such as growth, meat quality, reproduction, polled traits, disease resistance, environmental adaptability. Finally, explores potential telomere-to-telomere (T2T) assembly, structural variations (SVs), multi-omics techniques future breeding. These advancements collectively offer promising avenues enhancing improving traits.

Язык: Английский

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Genomic characterization of dryland adaptation in endangered Anxi cattle in China

Animal Genetics, Год журнала: 2024, Номер 55(3), С. 352 - 361

Опубликована: Март 4, 2024

Abstract Local species exhibit distinctive indigenous characteristics while showing unique productive and phenotypic traits. However, the advent of commercialization has posed a substantial threat to survival species. Anxi cattle, an endangered native breed in China, have evolved growth reproductive extreme desert semidesert ecosystems. In this study, we conducted genomic comparison 10 cattle genomes with those five other global populations/breeds assess genetic diversity identify candidate regions cattle. Population structure analyses revealed that are part East Asian clade, exhibiting higher than commercial breeds. Through selective sweep analysis, identified specific variations linked environmental adaptability Notably, several genes, including CERS3 involved regulating skin permeability antimicrobial functions, RBFOX2 associated cardiac development, SLC16A7 participated regulation pancreatic endocrine function, SPATA3 related reproduction. Our findings features dryland environments, provided invaluable insights for further research preservation, had important significance enriching domestic breeding gene bank.

Язык: Английский

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Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Март 4, 2025

Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of region have collectively contributed to shaping distinctive germplasm characteristics observed indigenous cattle through prolonged domestication. The different breeds exhibit distinct advantageous traits, which are an important source genetic variation because they might carry alleles that enable them adapt local environment tough feeding conditions. However, a comprehensive genomic landscape resources has yet be delineated. Herein, we employed 140 whole-genome sequencing data from across eight elucidate their diversity population structure. Utilizing both uniparental biparental markers, elucidated composition cattle, is closely correlated with geographic environment. A predominant East Asian indicine ancestry gradually diminishes towards north. analysis revealed high among populations low-to-moderate inbreeding coefficient, underscoring rich reservoir breeds. Additionally, gene flow between wild Bos species around was verified, highlighting localized introgression Gayal as critical factor successful adaptation hot humid environments. Our findings established SNPs database for facilitating resource conservation selective breeding. Moreover, these valuable insights into adaptive history contribute significantly our understanding evolutionary dynamics offer foundation future improvement strategies.

Язык: Английский

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Whole-genome sequencing reveals genomic diversity and selection signatures in Xia’nan cattle

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Июнь 5, 2024

Abstract Background The crossbreeding of specialized beef cattle breeds with Chinese indigenous is a common method genetic improvement. Xia’nan cattle, crossbreed Charolais and Nanyang China’s first breed independent intellectual property rights. After more than two decades selective breeding, exhibit robust physique, good environmental adaptability, tolerance to coarse feed, high meat production rates. This study analyzed the population structure, diversity, genomic variations using whole-genome sequencing data from 30 178 published data. Result ancestry estimating composition analysis showed that proportions for were mainly small amount cattle. Through diversity studies (nucleotide linkage disequilibrium decay), we found higher in Europe but lower native Then, used four methods detect genome candidate regions influencing excellent traits Among detected results, 42 genes (θπ CLR) 131 ( F ST XP-EHH) by different detection strategies. In addition, region BTA8 strong selection signals. Finally, conducted functional annotation on these may influence body development NR6A1 ), quality MCCC1 growth WSCD1 , TMEM68 MFN1 NCKAP5 immunity IL11RA CNTFR CCL27 SLAMF1 SLAMF7 NAA35 GOLM1 ). Conclusion We elucidated features structure some signals potentially associated crucial economic research provided basis further breeding improvements served as reference enhancements other

Язык: Английский

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A Whole-Genome Scan Revealed Genomic Features and Selection Footprints of Mengshan Cattle

Genes, Год журнала: 2024, Номер 15(9), С. 1113 - 1113

Опубликована: Авг. 23, 2024

(1) Background: Mengshan cattle from the Yimeng mountainous region in China stand out as a unique genetic resource, known for their adaptive traits and environmental resilience. However, these are currently endangered comprehensive genomic characterization remains largely unexplored. This study aims to address this gap by investigating features selection signals cattle. (2) Methods: Utilizing whole-genome resequencing data 122 cattle, including 37 newly sequenced we investigated population structure, diversity, signals. (3) Results: Our analyses revealed that current primarily exhibit European taurine ancestry, with distinct characteristics indicative of traits. We identified candidate genes associated immune response, growth traits, meat quality, neurodevelopment, shedding light on underlying attributes Enrichment analysis highlighted pathways related insulin secretion, calcium signaling, dopamine synapse, further elucidating basis phenotypic (4) Conclusions: results provide valuable insights research conservation efforts aimed at preserving resource. enhances understanding genetics underscores importance informing resources initiatives indigenous breeds.

Язык: Английский

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Local ancestry and selection in admixed Sanjiang cattle

Stress Biology, Год журнала: 2023, Номер 3(1)

Опубликована: Авг. 3, 2023

The majority of native cattle are taurine × indicine diverse phenotypes in the central region China. Sanjiang cattle, a typical breed region, play role human livelihood and have good adaptability, including resistance to dampness, heat, roughage, disease, thus regarded as an important genetic resource. However, history successful remains unknown. Here, we sequenced 10 genomes compared them 70 5 representative populations worldwide. We characterized genomic diversity formation process found that mixed ancestry (55.6%) (33.2%) dating approximately 30 generations ago, which has shaped genome cattle. Through ancestral fragment inference, selective sweep transcriptomic analysis, identified several genes linked lipid metabolism, immune regulation, stress reactions across mosaic showing excess or ancestry. Taurine might contribute meat quality, is more conducive adaptation hot climate conditions, making valuable resource for Our results will help us understand evolutionary components provide reference conservation breeding Chinese

Язык: Английский

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Global phylogenomic diversity of Brucella abortus: spread of a dominant lineage

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 29, 2023

Brucella abortus is a globally important zoonotic pathogen largely found in cattle hosts and typically transmitted to humans through contaminated dairy products or contact with diseased animals. Despite the long, shared history of humans, little known about how trade has spread this throughout world. Whole genome sequencing provides unparalleled resolution investigate global evolutionary bacterium such as B. by providing phylogenetic that been unobtainable using other methods. We report on large-scale analysis collected from 16 52 countries. used single nucleotide polymorphisms (SNPs) identify genetic variation 1,074 genomes maximum parsimony generated phylogeny identified four major clades. Two these clades, clade A (median date 972 CE; 95% HPD, 781–1142 CE) B 150 BCE; 515 BCE–164 CE), were exceptionally diverse for species are exclusively African origin where provenance known. The third clade, C 949 766–1102 had most isolates coming broad swath Middle East, Europe, Asia, also relatively high diversity. Finally, fourth D 1467 1367–1553 comprises large majority dominant but monomorphic group predominantly infects Europe Americas. These data consistent an subsequent probably movement infected cattle. hypothesize European arrival Americas starting 15th century introduced Western introduction few common breeds strains D. provide foundation comprehensive should be resource human veterinary epidemiology.

Язык: Английский

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A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

Journal of Animal Breeding and Genetics, Год журнала: 2023, Номер 141(3), С. 235 - 256

Опубликована: Дек. 25, 2023

Abstract In the past few decades, genomic selection and other refined strategies have been used to increase growth rate lean meat production of beef cattle. Nevertheless, fast rates cattle breeds are often accompanied by a reduction in intramuscular fat (IMF) deposition, impairing quality. Transcription factors play vital roles regulating adipogenesis lipogenesis Meanwhile, understanding role transcription has gained significant attention IMF deposition Therefore, aim this paper was provide comprehensive summary valuable insight into complex This review summarizes contemporary studies lipogenesis, genome‐wide analysis factors, epigenetic regulation nutritional metabolic signalling pathways, functional genomics methods, transcriptomic profiling adipose tissues, quality comparative with livestock species. conclusion, crucial promoting adipocyte development fatty acid biosynthesis They control tissue formation metabolism, thereby improving maintaining balance. Understanding processes which these regulate lipid metabolism will simplify marbling or composition

Язык: Английский

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Identification of Heilongjiang crossbred beef cattle pedigrees and reveals functional genes related to economic traits based on whole-genome SNP data

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Июль 25, 2024

To enhance the beef cattle industry, Heilongjiang Province has developed a new Crossbred variety through crossbreeding with exotic commercial breeds. This exhibits relatively excellent meat quality, and efficient reproductive performance, catering to market demands.

Язык: Английский

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