Disturbance of the Circadian System in Shift Work and Its Health Impact

Journal of Biological Rhythms, Год журнала: 2021, Номер 37(1), С. 3 - 28

Опубликована: Дек. 30, 2021

The various non-standard schedules required of shift workers force abrupt changes in the timing sleep and light-dark exposure. These result disturbances endogenous circadian system its misalignment with environment. Simulated night-shift experiments field-based studies both indicate that is resistant to adaptation from a day- night-oriented schedule, as determined by lack substantial phase shifts over multiple days centrally controlled rhythms, such those melatonin cortisol. There evidence disruption caused work results not only between external cycle, but also state internal desynchronization levels system. This case rhythms central pacemaker clock genes expression tissues peripheral blood mononuclear cells, hair follicle oral mucosa cells. disruptive effects atypical extend beyond profile canonical affects other transcripts human genome. In general, after several living at night, most rhythmic genome remain adjusted day-oriented dampened group amplitudes. contrast transcripts, metabolomics revealed metabolites hours when working nights, thus leading their Altogether, these sleep-wake emphasize all-encompassing impact work, can contribute increased risk medical conditions. Here, we review latest scientific regarding on system, alertness shift-working populations, discuss potential clinical impacts.

Язык: Английский

---

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

International Journal of Molecular Sciences, Год журнала: 2014, Номер 15(12), С. 23448 - 23500

Опубликована: Дек. 17, 2014

Currently, in developed countries, nights are excessively illuminated (light at night), whereas daytime is mainly spent indoors, and thus people exposed to much lower light intensities than under natural conditions. In spite of the positive impact artificial light, we pay a price for easy access during night: disorganization our circadian system or chronodisruption (CD), including perturbations melatonin rhythm. Epidemiological studies show that CD associated with an increased incidence diabetes, obesity, heart disease, cognitive affective impairment, premature aging some types cancer. Knowledge retinal photoreceptors discovery melanopsin ganglion cells demonstrate intensity, timing spectrum must be considered keep biological clock properly entrained. Importantly, not all wavelengths equally chronodisrupting. Blue which particularly beneficial daytime, seems more disruptive night, induces strongest inhibition. Nocturnal blue exposure currently increasing, due proliferation energy-efficient lighting (LEDs) electronic devices. Thus, development systems preserve rhythm could reduce health risks induced by chronodisruption. This review addresses state art regarding crosstalk between system.

Язык: Английский

---

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

European Journal of Neuroscience, Год журнала: 2018, Номер 51(1), С. 396 - 412

Опубликована: Окт. 25, 2018

Abstract Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non‐communicable diseases, including diabetes and cardiovascular disease. Disruption the internal circadian timing system concomitant sleep disturbances thought to play a critical role in development these health problems. Indeed, controlled laboratory studies have shown that short‐term misalignment restriction independently impair physiological processes, insulin sensitivity, energy expenditure, immune function, blood pressure cardiac modulation by autonomous nervous system. If allowed persist, acute effects may lead cardiometabolic diseases long term. Here, we discuss evidence for contributions disruption metabolic problems shift workers. Improving understanding mechanisms affected disturbance will contribute implementation strategies prevent or mitigate impact work.

Язык: Английский

---

Circadian rhythms and disorders of the timing of sleep

The Lancet, Год журнала: 2022, Номер 400(10357), С. 1061 - 1078

Опубликована: Сен. 1, 2022

Язык: Английский

---

Circadian regulation of depression: A role for serotonin

Frontiers in Neuroendocrinology, Год журнала: 2019, Номер 54, С. 100746 - 100746

Опубликована: Апрель 16, 2019

Язык: Английский

---