The relevance of daylight for humans

Biochemical Pharmacology, Год журнала: 2020, Номер 191, С. 114304 - 114304

Опубликована: Окт. 28, 2020

Daylight is ubiquitous and crucial for mammalian vision as well non-visual input to the brain via intrinsically photosensitive retinal ganglion cells (ipRGCs) that express photopigment melanopsin. The ipRGCs project circadian clock in suprachiasmatic nuclei thereby ensure entrainment 24-hour day-night cycle, changes daylength trigger appropriate seasonal behaviours. also perihabenular nucleus surrounding regions modulate mood, stress learning animals humans. Given light has strong direct effects on cognition, alertness, performance, sleep, can be considered a "drug" treat many clinical conditions. Light therapy already established winter other depressions sleep disorders. Beyond visual retina, daylight contributes prevent myopia young by its impact eye development, important Vitamin D synthesis bone health skin. sun most powerful source and, dependent dose, ultraviolet radiance toxic living organisms used disinfectant. Most research involves laboratory-based electric light, without dynamic spectral undergoes moment moment. There gap between importance of human beings amount being done this subject. taken granted an environmental factor, enjoyed or avoided, according More awareness architecture urban design beyond aesthetic values comfort may lead higher quality work environments. Although we do not yet have factual basis assumption natural overall "better" than debate mandates serious consideration sunlight just solar power but biologically necessary sustainable healthy living.

Язык: Английский

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Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Авг. 10, 2022

The circadian rhythm is crucial for physiological and behavioral functions. Chronotype, which represents individual preferences activity performance, associated with human health issues, particularly psychiatric disorders. This narrative review, focuses on the relationship between chronotype mental disorders, provides an insight into potential mechanism. Recent evidence indicates that (1) evening a risk factor depressive disorders substance use whereas morning protective factor. (2) Evening individuals bipolar disorder tend to have more severe symptoms comorbidities. (3) only related anxiety symptoms. (4) schizophrenia remains unclear, despite increasing their link. (5) significantly eating majority of studies focused binge Furthermore, underlying mechanisms or influence factors are described in detail, including clock genes, brain characteristics, neuroendocrinology, light/dark cycle, social factors, psychological sleep These findings provide latest chronotypes serve as valuable reference researchers.

Язык: Английский

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Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties

Phytomedicine, Год журнала: 2021, Номер 90, С. 153669 - 153669

Опубликована: Июль 22, 2021

Язык: Английский

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The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect

Nutrients, Год журнала: 2022, Номер 14(10), С. 2081 - 2081

Опубликована: Май 16, 2022

Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which often accompanied by gastrointestinal symptoms. Experiments have demonstrated that disorder intestinal microbial system structure plays crucial role in depression. The gut-brain axis manifests potential linkage between digestion central nervous (CNS). Nowadays, it has become an emerging trend to treat diseases targeting microorganisms (e.g., probiotics) combining mechanism. Combined research, we found incidence depression closely linked gut microbiota. Moreover, transformation microbiota considered both positive negative regulatory effects on development This article reviewed mechanism bidirectional interaction existing symptom-relieving measures antidepression treatments related microbiome.

Язык: Английский

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Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression

Neurochemical Research, Год журнала: 2022, Номер 47(10), С. 2909 - 2924

Опубликована: Июнь 11, 2022

Язык: Английский

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Depression in polycystic ovary syndrome: Focusing on pathogenesis and treatment

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Авг. 31, 2022

Polycystic ovary syndrome (PCOS) is one of the most prevalent gynecological endocrine conditions affecting reproductive women. It can feature a variety symptoms, such as obesity, insulin resistance, skin conditions, and infertility. Women with PCOS are susceptible to illnesses including mood disorders, diabetes, hypertension, dyslipidemia. Among them, depression common in has detrimental effect on quality life. Depression may occasionally develop due pathological traits PCOS, but its exact pathogenesis have eluded researchers date. Therefore, there an urgent need explore treatments PCOS. The present review discusses epidemiology potential pathogenic mechanisms underlying depression, well some factors causing hyperandrogenism, inflammation, Meanwhile, treatment strategies for lifestyle intervention, acupuncture, oral contraceptive pills, psychological insulin-sensitizer, also reviewed. To fully understand remains future large-scale multi-center randomized controlled trials in-depth mechanism studies.

Язык: Английский

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Circadian rhythms and mood disorders: Time to see the light

Neuron, Год журнала: 2023, Номер 112(1), С. 25 - 40

Опубликована: Окт. 18, 2023

Язык: Английский

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Cardiovascular disease and depression: a narrative review

Frontiers in Cardiovascular Medicine, Год журнала: 2023, Номер 10

Опубликована: Ноя. 21, 2023

In clinical practice, it is frequently observed that cardiac and psychological disorders co-occur, leading to the emergence of a field known as cardiovascular disease with depression. Depression, in particular, poses remarkable risk for evolution intimately relates adverse outcomes mortality. Moreover, individuals who are depressed exhibit higher susceptibility developing compared those good health. Patients diagnosed depression face heightened mortality within 5-year timeframe, their prognosis remains unsatisfactory even after receiving treatment targeting single disorder, notable recurrence rate. Psychological interventions conjunction medications commonly employed settings treating patients diseases, albeit limited effectiveness unfavorable prognosis. Traditional Chinese medicine (TCM), such Shuangxinfang, Chaihujialonggumuli, Yixin Ningshen Tablet, etc., have been reported Therapeutic effects combined Despite numerous articles documenting association between heart depression, there exists dearth studies elucidating precise pathogenesis target action diseases. This article endeavors consolidate epidemiological data, potential pathogenic mechanisms, available modalities Its primary objective unveil plausible co-morbid mechanisms suitable approaches, thereby offering novel insights prevention, diagnosis, management

Язык: Английский

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Melanin-concentrating hormone: A promising target for antidepressant treatment

Pharmacology Biochemistry and Behavior, Год журнала: 2025, Номер 250, С. 173999 - 173999

Опубликована: Март 11, 2025

Язык: Английский

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Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study

BMC Medicine, Год журнала: 2020, Номер 18(1)

Опубликована: Дек. 1, 2020

Abstract Background Sleep disturbances are prevalent among older adults and associated with various individual diseases. The aim of this study was to investigate whether sleep the speed multimorbidity development adults. Methods Data were gathered from Swedish National Aging Care in Kungsholmen (SNAC-K), an ongoing population-based subjects aged 60+ ( N = 3363). included a subsample n 1189) without at baseline (< 2 chronic diseases). Baseline derived Comprehensive Psychiatric Rating Scale categorized as none, mild, moderate–severe. number conditions throughout 9-year follow-up obtained clinical examinations. Linear mixed models used association between disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, psychotropic drug use. We repeated analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases outcome. Results Moderate–severe higher accumulation ß /year 0.142, p 0.008), regardless potential confounders. Significant positive associations also found moderate–severe neuropsychiatric 0.041, 0.016) 0.038, 0.025) but not cardiovascular remained stable when participants dementia, cognitive impairment, depression excluded. Conclusion finding that faster points towards importance early detection treatment possible strategy reduce

Язык: Английский

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