Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Cells, Год журнала: 2021, Номер 10(12), С. 3327 - 3327

Опубликована: Ноя. 26, 2021

The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. typical eukaryotes composed following phases: G1, S, G2, M phase. Cell progression mediated by cyclin-dependent kinases (Cdks) their regulatory cyclin subunits. However, driving force growth factor-initiated signaling pathways control activity various Cdk-cyclin complexes. While mechanism underlying role factor G1 phase has been largely revealed due early extensive research, little known regarding function regulating other phases cycle, including In this review, we briefly discuss process through phases, focus on activated factors receptor (mostly tyrosine kinases) phases.

Язык: Английский

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Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Фев. 27, 2023

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor rather than harming all rapidly dividing cells as in cytotoxic chemotherapy. The Response Evaluation Criteria Solid Tumor (RECIST) system has been used assess response therapy via changes the size of target lesions measured calipers, conventional anatomically based imaging modalities such computed tomography (CT), magnetic resonance (MRI), other methods. However, RECIST is sometimes inaccurate assessing efficacy targeted because poor correlation between treatment-induced necrosis or shrinkage. This approach might also result delayed identification when does confer a reduction size. Innovative molecular techniques have gained importance dawning era they can visualize, characterize, quantify biological processes at cellular, subcellular, even level anatomical level. review summarizes different pathways, various techniques, developed probes. Moreover, application for evaluating treatment related clinical outcome systematically outlined. In future, more attention should be paid promoting translation sensitivity biocompatible particular, multimodal technologies incorporating advanced artificial intelligence comprehensively accurately cancer-targeted therapy, addition RECIST-based

Язык: Английский

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Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy

Journal of Cancer, Год журнала: 2021, Номер 12(18), С. 5543 - 5561

Опубликована: Янв. 1, 2021

Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression, and treatment of cancer.Excess ROS can induce nuclear DNA, leading to cancer initiation.Not only that, but also inhibit T cells natural killer promote recruitment M2 polarization macrophages; consequently, escape immune surveillance defense.Furthermore, tumor invasion metastasis by triggering epithelial-mesenchymal transition cells.Interestingly, massive accumulation inhibits growth two ways: (1) blocking cell proliferation suppressing signaling pathway, cycle, biosynthesis nucleotides ATP (2) inducing death via activating endoplasmic reticulum stress-, mitochondrial-, P53-apoptotic pathways ferroptosis pathway.Unfortunately, adapt self-adaption system.This review highlighted bidirectional regulation cancer.The study further discussed application massively accumulated treatment.Of note, self-adaptive ability should be taken into consideration for prevention.

Язык: Английский

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Cell Cycle Progression and Synchronization: An Overview

Methods in molecular biology, Год журнала: 2022, Номер unknown, С. 3 - 23

Опубликована: Янв. 1, 2022

Язык: Английский

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CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Апрель 22, 2022

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown.Based on single gene knockout, we studied CDK6-PI3K axis ABCB1-mediated MDR in human cells. CRISPR/Cas9 technique was performed KB-C2 cells to knockout cdk6 or cdk4 gene. Western blot, RT-PCR and transcriptome analysis were investigate target deletion expression critical signaling factors. The effect deficiency cell apoptosis cycle analyzed using flow cytometry. In vivo studies study sensitivity tumors doxorubicin, tumor growth metastasis.Deficiency led remarkable downregulation ABCB1 reversal MDR. Transcriptomic revealed that CDK6 regulated series factors, among them, PI3K 110α 110β, KRAS MAPK10 downregulated, FOS-promoting autophagy CXCL1-regulating multiple factors upregulated. Notably, 110α/110β in-return downregulated synergizes regulating expression, which strengthened over either 110α/110β. High frequency alternative splicing (AS) premature mRNA induced CDK6, CDK4 level change confirmed alter level, them 10 common skipped exon (SE) events found. experiments demonstrated loss remarkably increased doxorubicin increasing drug accumulation tumors, resulting inhibition metastasis, as well survival nude mice.CDK6-PI3K new reverse reported for first time cancers. Pathways leading proliferation be accompanied deficiency.

Язык: Английский

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The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors

Pathology - Research and Practice, Год журнала: 2023, Номер 251, С. 154854 - 154854

Опубликована: Окт. 4, 2023

Язык: Английский

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Mechanosensitive Ion Channels and Their Role in Cancer Cells

Membranes, Год журнала: 2023, Номер 13(2), С. 167 - 167

Опубликована: Янв. 29, 2023

Mechanical forces are an inherent element in the world around us. The effects of their action can be observed both on macro and molecular levels. They also play a prominent role tissues cells animals due to presence mechanosensitive ion channels (MIChs) such as Piezo TRP families. essential many physiological processes human body. However, pathology has been observed. Recent discoveries have highlighted relationship between these development malignant tumors. Multiple studies shown that MIChs mediate proliferation, migration, invasion various cancer via mechanisms. This could show new potential biomarkers detection prognosis interesting therapeutic targets modern oncology. Our paper is review latest literature Piezo1 families mechanisms carcinogenesis different types cancer.

Язык: Английский

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CDK4/6 Inhibitors in Melanoma: A Comprehensive Review

Cells, Год журнала: 2021, Номер 10(6), С. 1334 - 1334

Опубликована: Май 28, 2021

Historically, metastatic melanoma was considered a highly lethal disease. However, recent advances in drug development have allowed significative improvement prognosis. In particular, BRAF/MEK inhibitors and anti-PD1 antibodies completely revolutionized the management of this Nonetheless, not all patients derive benefit or durable from these therapies. To overtake challenges, new clinically active compounds are being tested context clinical trials. CDK4/6 drugs already available practice preliminary evidence showed promising activity also melanoma. Herein we review literature to depict comprehensive landscape about We present molecular genetic background that might justify usage drugs, preclinical evidence, data, most ongoing

Язык: Английский

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Proteogenomic Profiling of Treatment-Naïve Metastatic Malignant Melanoma

Cancers, Год журнала: 2025, Номер 17(5), С. 832 - 832

Опубликована: Фев. 27, 2025

Melanoma is a highly heterogeneous disease, and deeper molecular classification essential for improving patient stratification treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover subtypes clinically relevant biomarkers. We performed an integrative analysis identify proteomic subtypes, assess impact BRAF V600 mutations, study profiles cellular composition tumor microenvironment. Clinical histopathological data were used support findings related tissue morphology, disease progression, outcomes. Our revealed five distinct that integrate immune stromal microenvironment components correlate with clinical parameters. demonstrated V600-mutated melanomas exhibit biological heterogeneity, where oncogene-induced senescence-like phenotype associated improved survival. This led proposed mortality risk-based may contribute more personalized strategies. Furthermore, strongly correlated progression outcomes, highlighting connective tissue-to-tumor ratio assessment as potential decision-making tool. identified melanoma-associated SAAV signature linked extracellular matrix remodeling SAAV-derived neoantigens targets anti-tumor responses. provides comprehensive melanoma, integrating insights features. The aid in development tailored diagnostic therapeutic strategies, management

Язык: Английский

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Insights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning

Physical Chemistry Chemical Physics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

GaMD trajectory-based deep leaning identifies phosphorylation-mediated effects on the function of CDK6.

Язык: Английский

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