Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals DOI Creative Commons
Jackson T. Baumgartner, Catherine S. McCaughey,

Hanna S. Fleming

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze selective halogenation reactions previously characterized within bacterial natural product biosynthetic pathways. However, the broader chemical roles and biological distribution of these halogenases remains to be explored. Using bioinformatic methods, we have defined VHPO subfamily regioselectively brominates alkyl quinolone (AQ) quorum sensing molecules.

Язык: Английский

Regioselective Halogenation of Lavanducyanin by a Site-Selective Vanadium-Dependent Chloroperoxidase DOI Creative Commons
Jackson T. Baumgartner, Shaun M. K. McKinnie

Organic Letters, Год журнала: 2024, Номер 26(27), С. 5725 - 5730

Опубликована: Июнь 27, 2024

Halogenated phenazine meroterpenoids are a structurally unusual family of marine actinobacterial natural products that exhibit antibiotic, antibiofilm, and cytotoxic bioactivities. Despite lack established halogenation biochemistry, genomic analysis

Язык: Английский

Процитировано

5
Regioselective halogenation of lavanducyanin by a site-selective vanadium-dependent chloroperoxidase DOI Creative Commons
Jackson T. Baumgartner, Shaun M. K. McKinnie

Опубликована: Май 21, 2024

Halogenated phenazine meroterpenoids are a structurally unusual family of marine actinobacterial natural products that exhibit antibiotic, anti-biofilm, and cytotoxic bioactivities. Despite lack established halogenation biochemistry, genomic analysis Streptomyces sp. CNZ-289, prolific lavanducyanin C2-halogenated derivative producer, suggested the involvement vanadium-dependent haloperoxidases. We subsequently discovered halogenase (LvcH), characterized it in vitro as regioselective chloroperoxidase, applied late-stage chemoenzymatic synthesis.

Язык: Английский

Процитировано

2
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals DOI Creative Commons
Jackson T. Baumgartner, Catherine S. McCaughey,

Hanna S. Fleming

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze selective halogenation reactions previously characterized within bacterial natural product biosynthetic pathways. However, the broader chemical roles and biological distribution of these halogenases remains to be explored. Using bioinformatic methods, we have defined VHPO subfamily regioselectively brominates alkyl quinolone (AQ) quorum sensing molecules.

Язык: Английский

Процитировано

1