Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Creative Commons

Cassandra Avila,

Martin Sarter

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain's attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson's disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders. Adaptive behavior involves selection behaviorally significant capacity selected action. Neuronal cortex integration attentional motor functions. Here demonstrated primarily influences actions (cued stops). turning was especially powerful which, as psychological trait, deploy attention. Together, our demonstrate role input selection, they emphasize experimental biopsychological significance investigating attentional-motor interface context broader differences styles.

Язык: Английский

Multi-muscle synergies in preparation for gait initiation in Parkinson’s disease DOI

Ali Falaki,

Cristian Cuadra, Mechelle M. Lewis

и другие.

Clinical Neurophysiology, Год журнала: 2023, Номер 154, С. 12 - 24

Опубликована: Июль 18, 2023

Язык: Английский

Процитировано

33
Apathy in Parkinson’s Disease: Clinical Patterns and Neurobiological Basis DOI Creative Commons
Matthieu Béreau, Vincent Van Waes, Mathieu Servant

и другие.

Cells, Год журнала: 2023, Номер 12(12), С. 1599 - 1599

Опубликована: Июнь 10, 2023

Apathy is commonly defined as a loss of motivation leading to reduction in goal-directed behaviors. This multidimensional syndrome, which includes cognitive, emotional and behavioral components, one the most prevalent neuropsychiatric features Parkinson’s disease (PD). It has been established that prevalence apathy increases PD progresses. However, pathophysiology anatomic substrate this syndrome remain unclear. seems be underpinned by impaired anatomical structures link prefrontal cortex with limbic system. can encountered prodromal stage fluctuating patients receiving bilateral chronic subthalamic nucleus stimulation. In these stages, may considered disorder embodies amotivational combined dopaminergic serotonergic denervation dopa-responsive. contrast, advanced patients, cognitive announces decline dementia, diffuse neurotransmitter system dysfunction Lewy pathology spreading no longer review, we discuss clinical patterns their treatment, neurobiological basis apathy, potential role involved pathways motivational apathy.

Язык: Английский

Процитировано

25
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer’s disease: relevance for precision medicine in neurodegenerative diseases DOI Creative Commons
Simone Lista, Andrea Vergallo, Stefan Teipel

и другие.

Ageing Research Reviews, Год журнала: 2022, Номер 84, С. 101819 - 101819

Опубликована: Дек. 13, 2022

Язык: Английский

Процитировано

30
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease DOI Creative Commons
Anders Björklund, Roger A. Barker

Brain, Год журнала: 2024, Номер 147(6), С. 1937 - 1952

Опубликована: Янв. 27, 2024

Abstract In recent years there has been a renewed interest in the basal forebrain cholinergic system as target for treatment of cognitive impairments patients with Parkinson’s disease, due part to need explore novel approaches treat symptoms disease and development more refined imaging tools that have made it possible monitor progressive changes structure function they evolve over time. parallel, emerging technologies allowing derivation authentic neurons from human pluripotent stem cells are providing new powerful exploration neuron replacement animal models disease-like decline. this review, we discuss rationale cell potential therapeutic strategy how approach can be explored rodent decline, building on insights gained extensive experimental work was performed primate 1980s 90s. Although therapies targeting so far focused mainly Alzheimer’s dementia may relevant condition. dementia, undergoes degeneration magnitude loss shown correlate level impairment. Thus, therapy aimed replace lost represents an interesting combat some major dementia.

Язык: Английский

Процитировано

7
Dysfunction of motor cortices in Parkinson’s disease DOI Creative Commons
Hong‐Yuan Chu, Yoland Smith, William W. Lytton

и другие.

Cerebral Cortex, Год журнала: 2024, Номер 34(7)

Опубликована: Июль 1, 2024

Abstract The cerebral cortex has long been thought to be involved in the pathophysiology of motor symptoms Parkinson’s disease. impaired cortical function is believed a direct and immediate effect pathologically patterned basal ganglia output, mediated by way ventral thalamus. However, recent studies humans with disease animal models have provided strong evidence suggesting that involvement much broader than merely serving as passive conduit for subcortical disturbances. In present review, we discuss disease–related changes frontal regions, focusing on neuropathology, plasticity, neurotransmission, altered network interactions. We will also examine exploring circuits potential targets neuromodulation treat

Язык: Английский

Процитировано

7
Management of freezing of gait — mechanism-based practical recommendations DOI
Anouk Tosserams, Alfonso Fasano, Moran Gilat

и другие.

Nature Reviews Neurology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1
Progression of regional cortical cholinergic denervation in Parkinson’s disease DOI
Nicolaas I. Bohnen, Stiven Roytman, Prabesh Kanel

и другие.

Brain Communications, Год журнала: 2022, Номер 4(6)

Опубликована: Ноя. 2, 2022

Abstract Cortical cholinergic deficits contribute to cognitive decline and other in Parkinson's disease. Cross-sectional imaging studies suggest a stereotyped pattern of posterior-to-anterior cortical denervation accompanying disease progression We used serial acetylcholinesterase PET ligand characterize the trajectory regional synapse disease, testing hypothesis deficits. The 16 subjects (4 females/12 males; mean age: 64.4 ± 6.7 years; duration: 5.5 4.2 Hoehn & Yahr stage: 2.3 0.6 at entry) completed 11C-methyl-4-piperidinyl propionate scans over 4–8 year period (median 5 years). Three-dimensional stereotactic surface projections volume-of-interest analyses were performed. Cholinergic integrity was assessed by magnitude, k3, hydrolysis propionate. Based on normative data, we generated Z-score maps for both k3 k1 parameters, latter as proxy cerebral blood flow. Compared with control subjects, baseline showed predominantly posterior Parkinson’s subjects. Interval change evidence cortices. In frontal cortices, an opposite gradient anterior-to-posterior found. topography changes exhibited regionally specific disconnection from changes. Interval-change analysis based k3/k1 ratio images (k3 adjustment flow changes) interval reductions (up 20%) ventral frontal, anterior cingulate Brodmann area 6 contrast, especially areas 17–19, largely proportional Our results partially support progressive posterior-to-cortical This appears characteristic activity declining flow, suggesting that are part generalized loss synapses. disproportionate relative suggests preferential or dysregulation synapses these regions. observations vulnerability is mediated diffuse processes affecting subpopulations afferents.

Язык: Английский

Процитировано

23
Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson’s disease DOI Creative Commons
Anna Radlicka-Borysewska, Judyta Jabłońska, Michał Lenarczyk

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Апрель 30, 2024

Parkinson’s disease (PD) is characterized by three main motor symptoms: bradykinesia, rigidity and tremor. PD also associated with diverse non-motor symptoms that may develop in parallel or precede dysfunctions, ranging from autonomic system dysfunctions impaired sensory perception to cognitive deficits depression. Here, we examine the role of progressive loss dopaminergic transmission behaviors related a mouse model (the TIF-IA DATCreERT2 strain). We found period 5 12 weeks after induction gradual neurons, mild became detectable, including changes distance between paws while standing as well swing speed step sequence. Male mutant mice showed no apparent olfactory acuity, anhedonia-like behaviors, normal learning an instrumental task; however, pronounced increase number operant responses performed was noted. Similarly, female neuron degeneration probabilistic reversal task sweet-taste preference, but again, robustly higher choices were task. In both males females, did not affect accuracy fraction rewarded responses. Taken together, these data reveal discrete, dopamine-dependent emerge early stages degeneration.

Язык: Английский

Процитировано

3
Cholinergic Basal Forebrain Integrity and Cognition in Parkinson's Disease: A Reappraisal of Magnetic Resonance Imaging Evidence DOI Creative Commons
Nicola M. Slater, Tracy R. Melzer, Daniel J. Myall

и другие.

Movement Disorders, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Cognitive impairment is a well‐recognized and debilitating symptom of Parkinson's disease (PD). Degradation in the cortical cholinergic system thought to be key contributor. Both postmortem vivo positron emission tomography (PET) studies have provided valuable evidence changes PD, which are pronounced PD dementia (PDD). A growing body literature has employed magnetic resonance imaging (MRI), noninvasive, more cost‐effective alternative PET, examine structural PD. This review provides comprehensive discussion methodologies findings that focused on relationship between basal forebrain (cBF) integrity, based T1‐ diffusion‐weighted MRI, cognitive function Nucleus basalis Meynert (Ch4) volume been consistently reduced cognitively impaired samples shown potential utility as prognostic indicator for future decline. However, extent Ch4, especially early stages decline remains unclear. In addition, change anterior cBF regions not well established. underscores importance continued cross‐sectional longitudinal research elucidate role dysfunction manifestations © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Язык: Английский

Процитировано

3
Cortico-striatal action control inherent of opponent cognitive-motivational styles DOI Open Access

Cassandra Avila,

Martin Sarter

Опубликована: Янв. 24, 2025

Turning on cue or stopping at a red light requires attending to such cues select action sequences, suppress action, in accordance with learned cue-associated rules. Cortico-striatal projections are an essential part of the brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used measure glutamate transients dorsomedial striatum (DMS) male and female rats walking treadmill executing cued turns stops. Prelimbic-DMS chemogenetically inhibited determine their behavioral necessity cortico-striatal origin cue-evoked transients. Furthermore, we investigated exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign STs), impact cognitive-motivational biases control. GTs executed more initiated slowly than STs. During turns, but not missed stops, concentrations higher In STs, turn cue-locked frequently peaked twice three times, contrasting predominately single peaks GTs. GTs, inhibition prelimbic-DMS attenuated rates increased number peaks. These findings indicate that release is tightly controlled by neuronal activity. contrast, from DMS glutamatergic terminals may be regulated other striatal circuitry, mediating suppression reward tracking. As dysfunction has been hypothesized contribute wide range disorders, including complex movement control deficits Parkinson’s disease compulsive drug taking, demonstration phenotypic contrasts implies presence individual vulnerabilities for disorders.

Язык: Английский

Процитировано

0