CNS Drugs,
Год журнала:
2023,
Номер
37(7), С. 599 - 637
Опубликована: Июнь 21, 2023
Even
though
language
is
essential
in
human
communication,
research
on
pharmacological
therapies
for
deficits
highly
prevalent
neurodegenerative
and
vascular
brain
diseases
has
received
little
attention.
Emerging
scientific
evidence
suggests
that
disruption
of
the
cholinergic
system
may
play
an
role
associated
with
Alzheimer's
disease
cognitive
impairment,
including
post-stroke
aphasia.
Therefore,
current
models
processing
are
beginning
to
appraise
implications
modulator
acetylcholine
functions.
Future
work
should
be
directed
further
analyze
interplay
between
language,
focusing
identifying
regions
receiving
innervation
susceptible
modulation
pharmacotherapy
improve
affected
domains.
The
evaluation
trials
impairment
thus
far
been
limited
coarse-grained
methods.
More
precise,
fine-grained
testing
needed
refine
patient
selection
detect
subtle
initial
phases
decline.
Additionally,
noninvasive
biomarkers
can
help
identify
depletion.
However,
despite
investigation
treatment
data
its
effectiveness
insufficient
controversial.
In
case
aphasia,
agents
showing
promise,
particularly
when
combined
speech-language
therapy
promote
trained-dependent
neural
plasticity.
explore
potential
benefits
investigate
optimal
strategies
combining
these
other
therapeutic
approaches.
Progress in Retinal and Eye Research,
Год журнала:
2024,
Номер
101, С. 101273 - 101273
Опубликована: Май 15, 2024
The
retina
is
an
emerging
CNS
target
for
potential
noninvasive
diagnosis
and
tracking
of
Alzheimer's
disease
(AD).
Studies
have
identified
the
pathological
hallmarks
AD,
including
amyloid
β-protein
(Aβ)
deposits
abnormal
tau
protein
isoforms,
in
retinas
AD
patients
animal
models.
Moreover,
structural
functional
vascular
abnormalities
such
as
reduced
blood
flow,
Aβ
deposition,
blood-retinal
barrier
damage,
along
with
inflammation
neurodegeneration,
been
described
mild
cognitive
impairment
dementia.
Histological,
biochemical,
clinical
studies
demonstrated
that
nature
severity
pathologies
brain
correspond.
Proteomics
analysis
revealed
a
similar
pattern
dysregulated
proteins
biological
pathways
patients,
enhanced
inflammatory
neurodegenerative
processes,
impaired
oxidative-phosphorylation,
mitochondrial
dysfunction.
Notably,
investigational
imaging
technologies
can
now
detect
AD-specific
deposits,
well
vasculopathy
neurodegeneration
living
suggesting
alterations
at
different
stages
links
to
pathology.
Current
exploratory
ophthalmic
modalities,
optical
coherence
tomography
(OCT),
OCT-angiography,
confocal
scanning
laser
ophthalmoscopy,
hyperspectral
imaging,
may
offer
promise
assessment
AD.
However,
further
research
needed
deepen
our
understanding
AD's
impact
on
its
progression.
To
advance
this
field,
future
require
replication
larger
diverse
cohorts
confirmed
biomarkers
standardized
retinal
techniques.
This
will
validate
aiding
early
screening
monitoring.
RSC Advances,
Год журнала:
2024,
Номер
14(15), С. 10304 - 10321
Опубликована: Янв. 1, 2024
Monoamine
oxidases
(MAOs)
inhibitors
could
decrease
reactive
oxygen
species
(ROS)
generation,
enhance
mono-aminergic
neural
transmission,
and
have
major
therapeutic
benefits
for
the
treatment
of
Alzheimer's
disease
(AD).
The Journal of Supercritical Fluids,
Год журнала:
2023,
Номер
204, С. 106117 - 106117
Опубликована: Ноя. 22, 2023
Epicarp
and
seed
of
Hass
avocado
(Persea
americana
Mill.)
are
agro-industrial
residues
rich
in
bioactive
compounds.
In
this
study,
a
pressurized
liquid
extraction
(PLE)
method
was
optimized
to
obtain
phenolic
compound-rich
extracts
with
neuroprotective
potential.
The
optimal
extracts,
obtained
from
100%
epicarp
pure
water
(0%
ethanol)
at
40
°C
100
bar,
demonstrated
high
yield
(26.8
±
0.9%)
total
phenol
content
(TPC
=
505
25
mg
gallic
acid
equivalent/g
dry
extract),
good
antioxidant
capacity
(ABTS
3350
179
µmol
Trolox
extract,
ORAC
0.14
0.01
µg/mL),
moderate
acetylcholinesterase
inhibition
(33.6
2.9
µg/mL).
UHPLC-ESI-QTOF-MS
analysis
the
tentatively
identified
acids,
alcohol
derivatives,
various
flavonoids;
namely
flavonols.
results
reveal
potential
processing
by-products,
particularly
epicarp,
as
source
agents.
proposed
PLE
methodology
be
sustainable
efficient
strategy
for
valorization.
Current Medicinal Chemistry,
Год журнала:
2024,
Номер
31(29), С. 4725 - 4744
Опубликована: Апрель 19, 2024
N-methyl-D-aspartate
(NMDA)
receptors,
i.e.,
inotropic
glutamate
are
important
in
synaptic
plasticity,
brain
growth,
memory,
and
learning.
The
activation
of
NMDA
is
done
by
neurotransmitter
co-agonist
(glycine
or
D-serine)
binding.
However,
the
over-activation
elevates
intracellular
calcium
influx,
which
causes
various
neurological
diseases
disorders.
Therefore,
to
prevent
excitotoxicity
neuronal
death,
inhibition
must
be
using
its
antagonist.
This
review
delineates
structure
subunits
conformational
changes
induced
after
binding
agonists
antagonists
(ifenprodil,
etc.).
Additionally,
reported
from
different
sources,
such
as
synthetic,
semisynthetic,
natural
resources,
explained
their
mechanism
action
pharmacological
role.
comprehensive
report
also
addresses
chemical
spacing
inhibitors
