Nutrients, Год журнала: 2024, Номер 16(21), С. 3711 - 3711
Опубликована: Окт. 30, 2024
Insomnia (sleeplessness) is a potential symptom of stress-induced depression/anxiety (DA), which induces TNF-α expression. Therefore, this study aimed to examine the effect
Язык: Английский
Cells, Год журнала: 2024, Номер 13(5), С. 423 - 423
Опубликована: Фев. 28, 2024
The involvement of central and peripheral inflammation in the pathogenesis prognosis major depressive disorder (MDD) has been demonstrated. increase pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, TNF-α) individuals with depression may elicit neuroinflammatory processes inflammation, mechanisms that, turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation dysbiosis induce alterations tryptophan metabolism, culminating decreased serotonin synthesis, impairments neuroplasticity-related mechanisms, glutamate-mediated excitotoxicity. This review aims highlight inflammatory (neuroinflammation, dysbiosis) involved pathophysiology MDD explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines evidence have indicated that addition antidepressants, physical exercise, probiotics, nutraceuticals (agmatine, ascorbic acid, vitamin D) possess effects their antidepressant properties. Further studies are necessary benefits these alternative therapies MDD.
Язык: Английский
Процитировано
65
Molecular Psychiatry, Год журнала: 2023, Номер 28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Язык: Английский
Процитировано
50
General Psychiatry, Год журнала: 2024, Номер 37(1), С. e101374 - e101374
Опубликована: Фев. 1, 2024
The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing microbiota-gut-brain axis, its metabolites regulate central nervous system through neural, endocrine immune pathways to ensure normal functioning of organism, tuning individuals’ health disease status. Short-chain fatty acids (SCFAs), main bioactive microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component axis In present review, roles major (acetate, propionate butyrate) pathophysiology depression summarised with respect chronic cerebral hypoperfusion, neuroinflammation, host epigenome neuroendocrine alterations. Concluding remarks biological mechanisms related will hopefully address clinical value microbiota-related treatments for
Язык: Английский
Процитировано
29
European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Фев. 27, 2024
The growing interest in the rapid and sustained antidepressant effects of dissociative anesthetic ketamine classic psychedelics, such as psilocybin, is remarkable. However, both psychedelics are known to induce acute mystical experiences; can cause symptoms out-of-body experience, while typically bring about hallucinogenic experiences, like a profound sense unity with universe or nature. role these experiences enhancing outcomes for patients depression currently an area ongoing investigation debate. Clinical studies have shown that following administration (S)-ketamine (esketamine) not directly linked their properties. In contrast, potential (R)-ketamine (arketamine), thought lack side effects, has yet be conclusively proven large-scale clinical trials. Moreover, although activation serotonin 5-HT
Язык: Английский
Процитировано
28
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105425 - 105425
Опубликована: Окт. 16, 2023
Язык: Английский
Процитировано
36
Molecular Psychiatry, Год журнала: 2023, Номер 28(12), С. 4968 - 4976
Опубликована: Июль 4, 2023
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience number of persistent neurological psychiatric known as long COVID or "brain fog". Studies autopsy samples from who died COVID-19 detected the brain. Furthermore, increasing evidence shows that Epstein-Barr virus (EBV) reactivation after might play role symptoms. Moreover, alterations microbiome contribute this article, author reviews detrimental effects on brain, biological mechanisms (e.g., EBV reactivation, changes gut, nasal, oral, lung microbiomes) underlying COVID. addition, discusses potential therapeutic approaches based gut-brain axis, including plant-based diet, probiotics prebiotics, fecal microbiota transplantation, vagus nerve stimulation, sigma-1 receptor agonist fluvoxamine.
Язык: Английский
Процитировано
35
Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106433 - 106433
Опубликована: Фев. 7, 2024
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated depression through gut–brain axis via vagus nerve. This study explored potential role gut–liver–brain nerve depression-like phenotypes mice cirrhosis. These underwent common bile duct ligation (CBDL), a method used to stimulate To assess behaviors, behavioral tests were conducted 10 days following either sham or CBDL surgeries. The displayed symptoms such as splenomegaly, elevated plasma levels interleukin-6 and tumor necrosis factor-α, decreased synaptic proteins prefrontal cortex (PFC), disrupted balance, changes blood metabolites (or lipids). Additionally, there positive negative correlations between relative abundance microbiome data Significantly, these reversed by performing subdiaphragmatic vagotomy. Intriguingly, improved after single injection arketamine, new antidepressant. results suggest that CBDL-induced mediated nerve, arketamine might offer treatment approach cirrhosis patients.
Язык: Английский
Процитировано
11
Neurobiology of Disease, Год журнала: 2024, Номер 193, С. 106440 - 106440
Опубликована: Фев. 16, 2024
Limited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated effects transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model IBS-C. In current study, C57BL/6 mice were randomly divided into normal control, IBS-C sham-electrostimulation (sham-ES), taVNS, drug groups. The taVNS on fecal pellet number, water content, gastrointestinal transit evaluated mice. assessed effect visceral hypersensitivity using colorectal distention test. 16S rRNA sequencing was used analyze microbiota experimental First, we found that increased compared with sham-ES group. Second, significantly decreased abdominal withdrawal reflex (AWR) score group, thus relieving hyperalgesia. Third, gut outcomes showed restored Lactobacillus abundance while increasing Bifidobacterium probiotic at genus level. Notably, number c-kit-positive interstitial cells Cajal (ICC) myenteric plexus region our study indicated effectively ameliorated ICC.
Язык: Английский
Процитировано
11
Journal of Anesthesia and Translational Medicine, Год журнала: 2024, Номер 3(3), С. 65 - 75
Опубликована: Июль 11, 2024
Ketamine, a dissociative anesthetic, is widely utilized in both human and veterinary anesthesia. Its (S)-enantiomer, esketamine, similarly employed for anesthesia analgesia. The anesthetic effects of ketamine esketamine arise from their antagonism the N-methyl-D-aspartate receptor (NMDAR). In field psychiatry, rapid-acting antidepressant properties severe depression have generated significant interest, resulting its increased off-label usage United States (U.S.). 2019, nasal spray received approval use U.S. Europe. However, concerns emerged regarding potential adverse effects, including long-term efficacy, addiction risks, suicide risk clinical settings. contrast, arketamine, (R)-enantiomer ketamine, exhibits superior longer-lasting rodent models depression, with fewer side compared to esketamine. Nevertheless, research on efficacy safety arketamine patients remains limited. This article provides concise exploration historical two enantiomers while also delving into future directions application these fields.
Язык: Английский
Процитировано
11
AJP Cell Physiology, Год журнала: 2024, Номер 327(1), С. C205 - C212
Опубликована: Июнь 3, 2024
Major depressive disorder (MDD) affects millions of individuals worldwide, leading to considerable social and economic costs. Despite advancements in pharmacological treatments, achieving remission remains a key challenge, with substantial number patients showing resistance existing therapies. This is often associated elevated levels proinflammatory cytokines, suggesting connection between inflammation, MDD pathophysiology, treatment efficacy. The observation increased immune activation about quarter resulted the distinction inflammatory noninflammatory endotypes. Although anti-inflammatory treatments show promise alleviating depression-like symptoms, responses are heterogeneous, thus highlighting importance identifying distinct endotypes tailor effective therapeutic strategies. intestinal microbiome emerges as crucial modulator mental health, mediating its effects partially through different pathways. Microbiota-derived short-chain fatty acids (SCFAs) significantly impact innate adaptive cells, regulating their differentiation, function, cellular response. Furthermore, gut-educated cells reach border regions central nervous system (CNS), glial cell functions. CNS modulates via efferent parts vagus nerve, afferent tracts concurrently transport information on peripheral inflammation back brain. bidirectional communication particularly relevant depression, allowing for stimulation nerve context depression In this review, we explore intricate relationship discuss how signals translated into depressive-like highlight immune-modulating avenues.
Язык: Английский
Процитировано
9