microRNA blood signature for localized radiation injury

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 1, 2024

A radiological accident, whether from industrial, medical, or malicious origin, may result in localized exposure to high doses of ionizing radiations, leading the development local radiation injury (LRI), that evolve toward deep ulceration and necrosis skin underlying tissues. Early diagnosis is therefore crucial facilitate identification management LRI victims. Circulating microRNAs (miRNA) have been studied as potential diagnostic biomarkers several diseases including hematological defects following whole-body irradiation (WBI). This study aims identify a blood miRNA signature associated with preclinical C57BL/6J mouse model hindlimb using different 10-MV X-ray lead injuries severities. To this end, we first performed broad-spectrum plasma profiling, followed by targeted validation step, on two independent animal cohorts. Using multivariate sparse partial least square discriminant analysis, identified panel eight circulating miRNAs able segregate mice according severity. Interestingly, these were previously WBI (miR-150-5p, miR-342-3p, miR-146a-5p), inflammation (miR-18a-5p, miR-148b-3p, miR-532-5p) (miR-139-5p, miR-195-5p). Our results suggest use suitable molecular for prognosis diagnosis.

Язык: Английский

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Chlorogenic acid targets SIRT6 to relieve UVB - induced UV damage

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Март 19, 2025

Язык: Английский

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The correlation between dermoscopy and clinical and pathological tests in the evaluation of skin photoaging

Skin Research and Technology, Год журнала: 2024, Номер 30(1)

Опубликована: Янв. 1, 2024

Abstract Background There are no standards for evaluating skin photoaging. Dermoscopy is a non‐invasive detection method that might be useful Objective To assess the correlation between dermoscopic evaluation of photoaging and clinical pathological evaluations. Methods The age, (Fitzpatrick classification, Glogau Photoaging Classification, Chung's standardized image ruler), histopathology (Masson staining MMP‐1 immunohistochemistry), dermoscopy (Hu's Isik's) 40 donor samples were analyzed statistically, Spearman rank analysis was performed. Results robust total Hu scores Isik dermoscopy. with higher than methods. strong telangiectases lentigo. Xerosis, superficial wrinkle, diffuse erythema, telangiectases, reticular pigmentation significantly correlated three Superficial wrinkles Masson, MMP‐1, various indicators, other items. Conclusion good histopathological examination. help evaluate

Язык: Английский

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TIMP3 deficiency accelerates UVB-induced HaCaT cell senescence by regulating ferroptosis

Photochemical & Photobiological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Язык: Английский

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Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging – A scoping review

Biochemistry and Biophysics Reports, Год журнала: 2025, Номер 42, С. 102011 - 102011

Опубликована: Апрель 15, 2025

Язык: Английский

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Recent advances in exosomal non‐coding RNA‐based therapeutic approaches for photoaging

Skin Research and Technology, Год журнала: 2023, Номер 29(9)

Опубликована: Сен. 1, 2023

Photoaging is a degenerative biological process that affects the quality of life. It caused by environmental factors including ultraviolet radiation (UVR), deep skin burns, smoking, active oxygen, chemical substances, and trauma. Among them, UVR plays vital role in aging process.

Язык: Английский

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The role and safety of UVA and UVB in UV-induced skin erythema

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Июнь 27, 2023

Background Different wavelengths of ultraviolet (UV) light cause skin damage through different mechanisms. Minimal erythema dose (MED) is usually used to clinically evaluate sensitivity radiation by inducing using B (UVB) or A (UVA) + UVB. Aims In this study, we detected changes in the blood flow at MED caused UVB and UVA optical coherence tomography (OCT) explain role bands rays induction. Methods Two irradiation areas on subjects' back were irradiated with alone (UVA: = 8:1). The absolute energy remained same UVA+UVB. At 24 h after irradiation, area OCT. Results Compared blank control, maximum depth, peak, total UVB-MED UVA+UVB-MED significantly increased. Notably, depth peak higher than UVA+UVB-MED. There was no significant difference perfusion between UVB-MED. Under energy, weaker alone. Conclusions analysis local OCT showed that

Язык: Английский

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Protective Mechanisms of Polyphenol-Enriched Blueberry Preparation in Preventing Inflammation in the Skin against UVB-Induced Damage in an Animal Model

Antioxidants, Год журнала: 2023, Номер 13(1), С. 25 - 25

Опубликована: Дек. 21, 2023

UVB significantly impacts the occurrence of cutaneous disorders, ranging from inflammatory to neoplastic diseases. Polyphenols derived plants have been found exhibit photoprotective effects against various factors that contribute skin cancer. During fermentation polyphenol-enriched blueberry preparation (PEBP), small oligomers polyphenols were released, thus enhancing their effects. This study aimed investigate protective PEBP on UVB-induced inflammation. Topical preparations applied dorsally shaved mice. Mice subsequently exposed and sacrificed 90 min after exposure. revealed pretreatment with inhibited recruitment mast neutrophil cells prevented loss thickness. Furthermore, findings show treatment resulted in downregulation miR-210, 146a, 155 upregulation miR-200c miR-205 compared UVB-irradiated Additionally, was reduce expression IL-6, IL-1β, TNFα, inhibiting COX-2 increasing IL-10 Moreover, DNA methylation analysis indicated might potentially activation inflammation-related pathways such as MAPK, Wnt, Notch, PI3K-AKT signaling. Our finding suggests topical application may effectively prevent damage by

Язык: Английский

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Chemical constituents and bioactivities of fermented rose (from Yunnan ) extract

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 8

Опубликована: Июль 5, 2024

Natural plant extracts have gained significant attention in research due to their low toxicity, and potent antioxidant, anti-aging properties. The present study investigated the phytochemical composition of a fermented rose extract (FRE), evaluated its skin whitening, activities

Язык: Английский

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Fermented black ginseng extract prevents UVB‐induced inflammation by regulating the nc886‐PKR pathway in human keratinocytes

Photodermatology Photoimmunology & Photomedicine, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 14, 2023

Abstract Background Continuous exposure of the skin to ultraviolet B (UVB) rays can cause inflammation and photodamage. In previous studies, we observed that upregulation nc886, a noncoding RNA (ncRNA), alleviate UVB‐induced through suppression protein kinase (PKR) pathway. We aim investigate effect fermented black ginseng extract (FBGE), which has been shown increase expression on in keratinocytes. Methods To confirm cytotoxicity FBGE, MTT assay was performed, no significant found human The efficacies FBGE were assessed qPCR, Western blotting, ELISA analysis confirmed regulation inflammation. Results results showed inhibited decrease nc886 methylated caused by UVB. It also prevented metalloproteinase‐9 (MMP‐9), metalloproteinase‐1 (MMP‐1), cyclooxygenase‐2 (COX‐2), prostaglandin E 2 (PGE2), interleukin‐8 (IL‐8) tumor necrosis factor‐α (TNF‐α). Additionally, suppressed PKR‐MAPK pathways activated Conclusion These implicate nc886‐PKR

Язык: Английский

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