Subacute Oral Toxicity Study of a New Polyherbal Formulation of Usadha on liver and Kidney Function of Wistar Rats DOI Open Access
I Nyoman Arsana,

Ni Ketut Ayu Juliasih,

Anak Agung Ayu Sauca Sunia Widyantari

и другие.

Biomedical & Pharmacology Journal, Год журнала: 2025, Номер 18(1), С. 899 - 908

Опубликована: Март 31, 2025

Usadha is a traditional Balinese medicine system that has long been used in ancient systems. However, so far there have no reports on its safety. This study aims to examine the effect of polyherbal hematology and blood biochemistry Wistar rats. The Completely Randomized Design with six treatments, namely supplementation doses 0 mg/kg bw/day (E0), 100 (E1), 200 (E2), 300 (E3), 400 (E4), 500 (E5). treatments were given for four weeks. variables measured complete biochemistry. Data analyzed by One-Way ANOVA continued Least Significant Difference test at 95% confidence interval. Polyherbal appears be safe consumption without significant risk side effects parameters liver function. Additional studies including histological analysis mechanism action will provide deeper insight into therapeutic Usadha. In conclusion, usada relatively kidney function results this support safety using Poliherbal as candidate herbal long-term consumption.

Язык: Английский

The effectiveness of diet and exercise in the management of obesity DOI Creative Commons

Nuridin Widya Pranoto,

Varhatun Fauziah,

Septriyan Anugrah

и другие.

Retos, Год журнала: 2024, Номер 58, С. 951 - 959

Опубликована: Июль 16, 2024

Background and objectives: Obesity is a growing global health problem becoming significant challenge in the clinical public fields. One of main concerns impact on an individual's quality life. This review aims to evaluate effectiveness various interventions, including physical activity diet, management obesity. Methodology: The selected studies involved population adults who were obese (aged 18 years over) had made lifestyle modifications through pattern changes, eating, activity, or both. A total 324 articles screened, which 25 duplicates. After screening process for suitability, 261 excluded. further 27 excluded due inappropriate study design incomplete data. 11 full-text then reviewed included our analysis. results showed that participants followed milk-based diet recorded decrease body weight -1.16 kg (confidence interval -1.66, -0.66 kg; p < 0.001) as well fat mass -1.49 -2.06, -0.92 0.001). Participants adopted alternate day fasting (ADF) eating achieved average loss -0.9% ± 0.6% low group -9.9% 1.1% group. Meanwhile, restricted calorie intake (Caloric Restriction/CR) -1.3% 0.7% -9.2% 1.2% tall body. Combining approximately 175 minutes intense per week with controlled up 5%. In conclusion, this systematic confirms most effective approach obesity combination strength cardiovascular training at least low-calorie tailored metabolic needs condition. Keywords: management; exercise efficacy; treatment;

Язык: Английский

Процитировано

4

Subacute Oral Toxicity Study of a New Polyherbal Formulation of Usadha on liver and Kidney Function of Wistar Rats DOI Open Access
I Nyoman Arsana,

Ni Ketut Ayu Juliasih,

Anak Agung Ayu Sauca Sunia Widyantari

и другие.

Biomedical & Pharmacology Journal, Год журнала: 2025, Номер 18(1), С. 899 - 908

Опубликована: Март 31, 2025

Usadha is a traditional Balinese medicine system that has long been used in ancient systems. However, so far there have no reports on its safety. This study aims to examine the effect of polyherbal hematology and blood biochemistry Wistar rats. The Completely Randomized Design with six treatments, namely supplementation doses 0 mg/kg bw/day (E0), 100 (E1), 200 (E2), 300 (E3), 400 (E4), 500 (E5). treatments were given for four weeks. variables measured complete biochemistry. Data analyzed by One-Way ANOVA continued Least Significant Difference test at 95% confidence interval. Polyherbal appears be safe consumption without significant risk side effects parameters liver function. Additional studies including histological analysis mechanism action will provide deeper insight into therapeutic Usadha. In conclusion, usada relatively kidney function results this support safety using Poliherbal as candidate herbal long-term consumption.

Язык: Английский

Процитировано

0