International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(17), С. 9526 - 9526
Опубликована: Авг. 23, 2022
Biofilms
are
complex
structures
formed
by
bacteria,
fungi,
or
even
viruses
on
biotic
and
abiotic
surfaces,
they
can
be
found
in
almost
any
part
of
the
human
body.
The
prevalence
biofilm-associated
diseases
has
increased
recent
years,
mainly
because
frequent
use
indwelling
medical
devices
that
create
opportunities
for
clinically
important
bacteria
fungi
to
form
biofilms
either
device
neighboring
tissues.
As
a
result
their
resistance
antibiotics
host
immunity
factors,
have
been
associated
with
development
persistence
several
diseases.
inability
completely
eradicate
drastically
increases
burden
disease
both
patient
healthcare
system.
Therefore,
it
is
crucial
develop
innovative
ways
tackle
growth
biofilms.
This
review
focuses
dental-
implant-associated
biofilm
infections,
humans,
potential
therapeutic
intervention
strategies,
including
advances
pharmacology
biomedical
engineering.
It
lists
current
strategies
used
control
formation
biofilms,
novel
carriers,
antiseptics
disinfectants,
small
molecule
anti-biofilm
agents,
surface
treatment
nanostructure
functionalization,
as
well
multifunctional
coatings
particularly
suitable
providing
antibacterial
effects
implants,
treat
implant-related
bacterial
infections.
Nanomaterials,
Год журнала:
2020,
Номер
10(11), С. 2318 - 2318
Опубликована: Ноя. 23, 2020
Silver
nanoparticles
(AgNPs)
represent
one
of
the
most
explored
categories
nanomaterials
for
new
and
improved
biomaterials
biotechnologies,
with
impressive
use
in
pharmaceutical
cosmetic
industry,
anti-infective
therapy
wound
care,
food
textile
industry.
Their
extensive
versatile
applicability
relies
on
genuine
easy-tunable
properties
nanosilver,
including
remarkable
physicochemical
behavior,
exceptional
antimicrobial
efficiency,
anti-inflammatory
action
antitumor
activity.
Besides
commercially
available
clinically
safe
AgNPs-based
products,
a
substantial
number
recent
studies
assessed
nanosilver
as
therapeutic
agents
augmented
alternative
strategies
cancer
therapy,
sensing
diagnosis
platforms,
restorative
regenerative
biomaterials.
Given
beneficial
interactions
AgNPs
living
structures
their
nontoxic
effects
healthy
human
cells,
they
an
accurate
candidate
various
biomedical
products.
In
present
review,
important
applications
products
biomedicine
are
considered.
Water,
Год журнала:
2023,
Номер
15(3), С. 384 - 384
Опубликована: Янв. 17, 2023
Removing
organic
pollutants,
textile
dyes,
and
pharmaceutical
wastes
from
the
water
bodies
has
become
an
essential
requirement
for
a
safe
environment.
Therefore,
present
study
aimed
to
prepare
semiconductor
zinc
oxide
nanoparticles
(ZnO
NPs)
plasmonic
Ag-supported
ZnO
nanocomposite
(ZnO–Ag)
using
environmentally
friendly
bio-approach
as
alternative
hazardous
synthesis
approaches.
NPs
ZnO–Ag
were
characterized
by
UV–Vis
diffuse
reflectance
spectroscopy
(UV–DRS)
(the
exhibited
absorption
band
between
450–550
nm,
attributed
Ag
surface
plasmon
resonance
(SPR)),
Photoluminescence
(PL)
spectral
investigation,
which
revealed
PL
emission
intensity
of
was
lower
than
pure
NPs,
describing
extended
electron-hole
pair
(e--h+)
lifespan
photogenerated
charge
carriers,
Fourier
transform
infrared
(FTIR),
FT-Raman,
X-ray
diffraction
(XRD)
analyses
deduced.
In
addition,
energy
dispersive
(SEM-EDX),
transmission
electron
microscopy
(TEM),
thermogravimetric
analysis
(TGA)
performed
further
ascertained
successful
biosynthesis
thermally
stable
Nps
nanocomposite.
The
as-prepared
displayed
increased
photocatalytic
characteristics
due
decline
in
bandgap
3.02
eV
2.90
(ZnO–Ag
nanocomposite).
activity
developed
degradation
methylene
blue
(MB)
dye,
primary
industry
released
water-pollutant,
conducted
under
UV
light
irradiation.
Meanwhile,
maximum
%
MB
dye
molecules
attained
98.0
after
60
min
exposure
UV-light
Increased
nanocomposites
faster
rate
achieved
deposition
(SPR)
effect
possessed
NPs.
oxidative
route
that
resulted
production
hydroxyl
radicals
(OH•).
SPR
photocatalyst
induced
synergistic
enhancement
optical
response
separation
photo-induced
carriers.
combined
gives
comprehensive
information
directions
future
research
on
noble
metal-modified
nanocatalysts
direct
applications
water.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 1109 - 1128
Опубликована: Март 1, 2023
Abstract:
The
emergence
of
multidrug-resistant
bacteria
has
been
deemed
a
global
crisis
that
affects
humans
worldwide.
Novel
anti-infection
strategies
are
desperately
needed
because
the
limitations
conventional
antibiotics.
However,
increasing
gap
between
clinical
demand
and
antimicrobial
treatment
innovation,
as
well
membrane
permeability
obstacle
especially
in
gram-negative
fearfully
restrict
reformation
antibacterial
strategy.
Metal-organic
frameworks
(MOFs)
have
advantages
adjustable
apertures,
high
drug-loading
rates,
tailorable
structures,
superior
biocompatibilities,
enabling
their
utilization
drug
delivery
carriers
biotherapy
applications.
Additionally,
metal
elements
MOFs
usually
bactericidal.
This
article
provides
review
state-of-The-art
design,
underlying
mechanisms
applications
MOF-
MOF-based
materials.
In
addition,
existing
problems
future
perspectives
materials
also
discussed.
Keywords:
MOF,
nanomaterial,
antibacterial,
mechanism,
application
Nanomaterials,
Год журнала:
2021,
Номер
11(10), С. 2489 - 2489
Опубликована: Сен. 24, 2021
Titanium
(Ti)
and
its
alloys
offer
favorable
biocompatibility,
mechanical
properties
corrosion
resistance,
which
makes
them
an
ideal
material
choice
for
dental
implants.
However,
the
long-term
success
of
Ti-based
implants
may
be
challenged
due
to
implant-related
infections
inadequate
osseointegration.
With
development
nanotechnology,
nanoscale
modifications
application
nanomaterials
have
become
key
areas
focus
research
on
Surface
use
various
coatings,
as
well
controlled
release
antibiotics
or
proteins,
improved
osseointegration
soft-tissue
integration
implants,
their
antibacterial
immunomodulatory
functions.
This
review
introduces
recent
nano-engineering
technologies
materials
used
in
topographical
surface
coatings
These
advances
are
discussed
detailed,
including
evaluation
evidence
toxicity,
antimicrobial
activities
in-vivo
performances.
The
comparison
between
these
attempts
at
reveals
that
there
still
gaps
must
addressed
towards
clinical
translation.
For
instance,
customized
three-dimensional
printing
technology
stimuli-responsive,
multi-functional
time-programmable
implant
surfaces
holds
great
promise
advance
this
field.
Furthermore,
vivo
studies
under
physiological
conditions
required
ensure
nanomaterial-modified
Materials & Design,
Год журнала:
2020,
Номер
196, С. 109142 - 109142
Опубликована: Сен. 10, 2020
Although
numerous
reports
have
elucidated
the
neurotoxic
impacts
of
Ti-6Al-4V
(Ti64)
due
to
presence
vanadium,
it
is
most
widely
used
biomedical
Ti
material.
This
because
exhibits
significantly
better
mechanical
performance
characteristics
than
those
pure
Ti.
In
addition
possibility
facilitating
production
customized
medicines,
selective
laser
melting
(SLM)
additive
manufacturing
(AM)
can
enable
match
properties
Ti64
by
utilizing
several
mechanisms
such
as
grain
refinement
and
solid
solution
strengthening.
These
results
be
obtained
high
cooling
rate
AM
process
via
a
possible
modification
in
alloy
chemistry
Herein,
we
report
novel
approach
that
endows
prepared
with
excellent
(ultimate
tensile
strength,
yield
elongation,
microhardness
1057.05
MPa,
784.59
24.09%,
307
Hv,
respectively),
corrosion
resistance,
biocompatibility,
while
reducing
cost
powder.
The
material
developed
this
study
has
significant
potential
for
use
an
advanced
variety
applications
dental
bone
structure
replacement.
Furthermore,
act
low-cost
alternative
materials
Ti-6Al-4V.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2021,
Номер
9
Опубликована: Дек. 7, 2021
Titanium
and
its
alloys
are
dominant
material
for
orthopedic/dental
implants
due
to
their
stable
chemical
properties
good
biocompatibility.
However,
aseptic
loosening
peri-implant
infection
remain
problems
that
may
lead
implant
removal
eventually.
The
ideal
orthopedic
should
possess
both
osteogenic
antibacterial
do
proper
assistance
in
situ
inflammatory
cells
anti-microbe
tissue
repair.
Recent
advances
surface
modification
have
provided
various
strategies
procure
the
harmonious
relationship
between
microenvironment.
In
this
review,
we
provide
an
overview
of
latest
endow
titanium
with
bio-function
anti-infection
properties.
We
state
methods
they
use
preparing
these
efficient
surfaces
offer
further
insight
into
interaction
devices
local
biological
environment.
Finally,
discuss
unmet
needs
current
challenges
development
materials
bone
implantation.
Biomaterials Research,
Год журнала:
2021,
Номер
25(1)
Опубликована: Фев. 12, 2021
Abstract
Background
Herein,
we
first
time
used
the
gum
Moringa
oleifera
as
reducing
and
capping
agent
for
successful
synthesis
of
silver
nitrate
zinc
oxide
nanoparticles(NPs)
through
green
approach.
This
study
was
aimed
to
check
antibacterial
activities
synthesized
NPs
against
multidrug
resistant
bacteria
methicillin-resistant
Staphylococcus
aureus
(MRSA).
Methods
Aqueous
solutions
AgNO
3
purified
powder
were
mixed
with
1:1
ratio,
autoclaved
at
120
o
C
2
min.
pellet
collected
after
centrifugation
10,000
g
20
ZnO
prepared
by
mixing
metal
salt
with1:1
heated
(70
C)
stirred
100
rpm
4
h
followed
Pellet
washed
calcinated
400
h.
Antibacterial
potential
E.
coli,
S.
(MRSA)
assessed
widely
Kirby-Bauer
antibiotic
susceptibility
test.
Results
Optical
observation
colour
change
from
transparent
dark
UV-Visible
analysis
confirmed
NPs.
Fourier
transform
infrared
spectroscopy
(FTIR)
nonmaterial
revealed
characteristic
AgNPs
stretch
vibrations
wave
number
523
cm
−
1
471
resectively.
Crystalline
nature
x-ray
diffraction
pattern
clear
sharp
Peaks.
Scanning
electron
microscopy
(SEM)
good
surface
morphology
50nm
60nm
size
respectively.
exhibited
excellent
activity
coli
(with
zone
inhibition
21
±
02mm
22
03mm)
S.aureus
(
03mm
02mm)
while
observed
“super
bug”
16
ad
17
if
inhibitions
Conclusions
novel
addition
Gum
based
nanoparticles
will
open
new
dimensions
in
field
nanomedicine
pharmaceutics
especially
MDR
bacterial
strains.
