Brazilian Dental Journal,
Год журнала:
2022,
Номер
33(1), С. 1 - 12
Опубликована: Фев. 1, 2022
Abstract
Dental
implants
made
of
titanium
(Ti)
material
is
recognized
as
the
leading
treatment
option
for
edentulous
patients’
rehabilitation,
showing
a
high
success
rate
and
clinical
longevity.
However,
dental
implant
surface
acts
platform
microbial
adhesion
accumulation
once
exposed
to
oral
cavity.
Biofilm
formation
on
surfaces
has
been
considered
main
etiologic
factor
induce
inflammatory
diseases,
known
peri-implant
mucositis
peri-implantitis;
latter
being
key
reason
late
failure.
Different
factors,
such
biofilm
matrix
production,
source
carbohydrate
exposure,
cross-kingdom
interactions,
have
encouraged
increased
implants,
microbiological
community
shift
from
healthy
pathogenic
state,
increasing
inflammation
favoring
tissue
damage.
These
factors
combined
with
spatial
organization
biofilms,
reduced
antimicrobial
susceptibility,
complex
composition,
irregular
topography
hamper
control
killing.
In
spite
well-known
etiology,
there
still
no
consensus
regarding
best
protocol
treat
disease.
this
sense,
different
coatings
Ti
treatments
proposed
in
order
reduce
loads
polymicrobial
infections
implantable
devices.
Therefore,
critical
review
aims
discuss
current
evidence
central
related
pathogenesis
process
implant-related
infections.
Moreover,
potential
modifications
anti-biofilm
properties
devices
discussed
shed
light
further
promising
strategies
peri-implantitis.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100586 - 100586
Опубликована: Фев. 15, 2023
With
the
aging
of
population
and
rapid
improvement
public
health
medical
level
in
recent
years,
people
have
had
an
increasing
demand
for
orthopedic
implants.
However,
premature
implant
failure
postoperative
complications
frequently
occur
due
to
implant-related
infections,
which
not
only
increase
social
economic
burden,
but
also
greatly
affect
patient's
quality
life,
finally
restraining
clinical
use
Antibacterial
coatings,
as
effective
strategy
solve
above
problems,
been
extensively
studied
motivated
development
novel
strategies
optimize
implant.
In
this
paper,
a
variety
antibacterial
coatings
recently
developed
implants
were
briefly
reviewed,
with
focus
on
synergistic
multi-mechanism
multi-functional
smart
that
are
more
potential
use,
thereby
providing
theoretical
references
further
fabrication
high-performance
satisfying
complex
needs.
Bioactive Materials,
Год журнала:
2023,
Номер
27, С. 15 - 57
Опубликована: Март 27, 2023
Titanium
(Ti)
and
its
alloys
have
been
widely
used
as
orthopedic
implants,
because
of
their
favorable
mechanical
properties,
corrosion
resistance
biocompatibility.
Despite
significant
success
in
various
clinical
applications,
the
probability
failure,
degradation
revision
is
undesirably
high,
especially
for
patients
with
low
bone
density,
insufficient
quantity
or
osteoporosis,
which
renders
studies
on
surface
modification
Ti
still
active
to
further
improve
results.
It
discerned
that
physicochemical
properties
directly
influence
even
control
dynamic
interaction
subsequently
determines
rejection
implants.
Therefore,
it
crucial
endow
bulk
materials
specific
high
bioactivity
can
be
performed
by
realize
osseointegration.
This
article
first
reviews
characteristics
conventional
techniques
involving
mechanical,
physical
chemical
treatments
based
formation
mechanism
modified
coatings.
Such
methods
are
able
but
surfaces
static
state
cannot
respond
biological
cascades
from
living
cells
tissues.
Hence,
beyond
traditional
design,
responsive
avenues
then
emerging.
The
stimuli
sources
functionalization
originate
environmental
triggers
physiological
triggers.
In
short,
this
review
surveys
recent
developments
engineering
materials,
a
emphasis
advances
functionality,
provides
perspectives
improving
biocompatibility
Chemical Engineering Journal,
Год журнала:
2022,
Номер
441, С. 136003 - 136003
Опубликована: Март 26, 2022
Ti
and
Ti-alloys
are
widely
utilized
as
suitable
biomaterials
for
implants,
since
they
present
good
biocompatibility
mechanical
properties.
However,
can
be
an
ideal
substrate
bacteria
attachment,
promoting
biofilm
infections.
Biomaterial-associated
infections
is
one
of
the
major
healthcare
challenges
that
currently
faced
by
humanity.
This
fact
causes
increased
morbidity
distress
in
patients,
along
with
high
economic
costs
due
to
hospitalizations.
There
several
strategies
overcome
infection
associated
especially
plasma
electrolytic
oxidation
(PEO)
process.
PEO
highly
effective
production
hard,
porous,
wear-
corrosion-resistant,
well
biocompatible
coatings.
Additionally,
this
method
applied
introduce
antibacterial
coatings,
most
prevalent
ones
being
bacteria-killing
bacteria-repelling.
Thus,
review,
formation
implications
implants
presented,
mechanisms
presently
known.
The
effect
on
ability
will
then
discussed
detail.
Finally,
procedure
parameters
modifications
lead
performance
presented.
Journal of Magnesium and Alloys,
Год журнала:
2022,
Номер
10(9), С. 2354 - 2383
Опубликована: Сен. 1, 2022
Recently,
developing
bioactive
and
biocompatible
materials
based
on
Mg
Mg-alloys
for
implant
applications
has
drawn
attention
among
researchers
owing
to
their
suitable
body
degradability.
Implementing
its
alloys
reduces
the
risk
of
long-term
incompatibility
with
tissues
because
close
mechanical
properties
no
need
re-operation
remove
implant.
Nevertheless,
degradation
rate
needs
be
controlled
production
hydrogen
gas
accumulation
bubbles
increases
local
pH
around
implants.
To
confine
integrity
implants
body,
corrosion
concern
in
fluid
requires
addressed.
Surface
modification
as
one
effective
strategies
can
improve
resistance.
Besides,
it
creates
a
surface
bone
grafting
cell
growth.
The
development
proper
surface-coated
appropriate
techniques
approaches.
Plasma
electrolytic
oxidation
(PEO)
coating
provide
protection
by
providing
ceramic
layer
improving
implant's
biocompatibility.
Herein,
general
review
in-vivo
in-vitro
evaluation
PEO
coatings
been
carried
out.
Recent
advances
have
discussed,
however,
reliable
laboratory
models
predict
is
still
valid.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(9), С. 11507 - 11519
Опубликована: Фев. 28, 2023
Implant-associated
infection
(IAI)
caused
by
pathogens
colonizing
on
the
implant
surface
is
a
serious
issue
in
trauma-orthopedic
surgery,
which
often
leads
to
failure.
The
complications
of
IAI
bring
big
threat
clinical
practice
implants,
accompanied
significant
economic
cost
and
long
hospitalization
time.
In
this
study,
we
propose
an
antibiotics-free
strategy
address
IAI-related
challenges
using
biodegradable
cytocompatible
hydrogel
coating.
To
achieve
this,
novel
system
was
developed
combine
synergistic
effects
good
cell
affinity
antibacterial
properties.
material
prepared
modifying
photocross-linkable
gelatin-based
polymer
(GelMA)
with
cationic
quaternary
ammonium
salt
(QAS)
groups
via
mild
simple
synthesis
procedure.
By
engineering
length
hydrophobic
carbon
chain
QAS
group
degree
functionalization,
resulting
GelMA-octylQAS
exhibited
integration
mechanical
properties,
biodegradability,
excellent
bactericidal
activity
against
various
types
bacteria,
high
cytocompatibility
mammalian
cells.
When
coated
onto
situ
cross-linking
procedure,
our
demonstrated
superior
antimicrobial
ability
infective
model
femoral
fracture
rats.
Our
results
suggest
that
might
provide
promising
platform
for
preventing
treating
IAI.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(17)
Опубликована: Янв. 9, 2024
Abstract
Bacterial
infection
and
inferior
osseointegration
are
major
complications
associated
with
titanium
(Ti)
based
implants.
Although
surface‐engineered
zinc
oxide
(ZnO)
nanorods
exhibit
remarkable
antibacterial
ability,
their
potential
biomedical
applications
hampered
by
pronounced
cytotoxicity.
Herein,
inspired
the
in
vivo
degradation
process
of
znic,
ZnO
converted
into
thermodynamically
more
stable
phosphate
(Zn
3
(PO
4
)
2
）through
a
simple
hydrothermal
treatment
hydrogen
solution.
By
adjusting
conversion
ratio,
surface
morphology,
release
ions
2+
),
generation
reactive
oxygen
species
can
be
finely
tailored
to
overcome
cytotoxicity
while
preserving
capability.
Furthermore,
an
optimized
amount
Zn
released
from
ZnO/Zn
hybrid
coating
enhances
osteogenic
differentiation
extracellular
matrix
mineralization
human
bone
marrow
mesenchymal
stem
cells
reprogramming
metabolic
configuration.
An
implant‐related
model
rabbit
femurs
indicates
that
even
promote
presence
pathogenic
bacteria.
This
modification
strategy
which
endows
Ti‐based
implants
superior
anti‐bacterial
pro‐osteogenic
properties
holds
great
clinical
for
orthopedic
dental
applications.
